主要研究内容：1、植物免疫分子机制；2、生物技术通用方法的研究。             

1）植物免疫分子机制。植物与病原微生物共同进化过程中形成了复杂的免疫系统。植物通过免疫受体识别不同的病原物，然后以一系列蛋白磷酸化过程将信号传递到胞内，激活抗病防卫反应。另外，不同于小种特异性抗性，植物还具有同时针对多种病原的持久抗性，即广谱抗性。本课题组一方面致力于植物应对外界病原微生物刺激的蛋白磷酸化信号网络解析，探讨植物免疫信号转导的方式及调控机制；另一方面，深入研究植物广谱抗性的分子机制，为培育广谱、持久的植物抗病品种提供重要的理论支撑

2) 生物技术通用方法。技术进步推动科学创新。本课题组致力于开发新型的生物技术方法，为植物功能基因研究和遗传改良提供工具。近年来，我们课题组建立了植物目标蛋白时空高效调控系统及基因组编辑技术，尤其是CRISPR/Cas9系统为植物基因功能研究及精准育种提供了重要的技术支撑，极大地加快了作物分子育种的步伐。我们将在前期良好的工作基础上，继续生物技术通用方法的研究和探索，并尝试拓展它们在重要农作物遗传改良中的应用。

发表的主要论文 （#Co-First Author; *Corresponding Author）
                                                                                                 1.Haocheng Zhu#, Xu Qin#, Leyan Wei#, Dandan Jiang#, Qiao Zhang, Wenqian Wang,Ronghong Liang, Rui Zhang, Kang Zhang, Guanwen Liu, Kevin Tianmeng Zhao, Kunling Chen, Jin-Long Qiu*, Caixia Gao*.(2025).Engineered geminivirus replicons enable rapid in planta directed evolution.Sience(Accepted).                                                                    

2.Minxiang Yu#, Jie Wu#, Cuihuan Zhao,Jin-Long Qiu*.(2025).Exploring plant protein functions through
structure-based clustering. Trends in Plant Science.https://doi.org/10.1016/j.tplants.2025.03.014.                     

3.Jie Wu, Xiao-Chen Wang, Jin-Long Qiu*.(2025).Deciphering Natural Product Secrets by Probing Biosynthetic Activation.SCIENCE CHINA Life Sciences.https://www.sciengine.com/doi/10.1007/s11427-025-3054-5.                                                

4.Zengqian Wang, Guiqing Yang, Dandan Zhang, Guangxin Li,Jin-Long Qiu*, Jie Wu*.(2024).Isochorismate synthase is required for phylloquinone,but not salicylic acid biosynthesis in rice.aBIOTECH,https://doi.org/10.1007/s42994-024-00166-4.

5.Dandan Zhang, Bin Lv and Jin-Long Qiu*. (2022). Being tough: the secret weapon of plants against vascular pathogens.Molecular Plant, DOI: https://doi.org/10.1016/j.molp.2022.04.007.

6.Shengnan Li#, Dexing Lin#, Yunwei Zhang#, Min Deng#, Yongxing Chen, Bin Lv, Boshu Li, Yuan Lei, Yanpeng Wang, Long Zhao, Yueting Liang, Jinxing Liu, Kunling Chen, Zhiyong Liu, Jun Xiao*, Jin-Long Qiu* and Caixia Gao*. (2022). Genome-edited powdery mildew resistance in wheat without growth penalties.Nature, 602(7897): 455-460.

7.Dandan Jiang#, Dandan Zhang#, Shengnan Li#, Yueting Liang, Qianwei Zhang, Xu Qin, Jinlan Gao and Jin-Long Qiu*. (2022). Highly efficient genome editing in Xanthomonas oryzae pv. oryzae through repurposing the endogenous type I-C CRISPR-Cas system.Molecular Plant Pathology, 23(4): 583-594.

8.Rui Wang#, Dandan Zhang#, Shengnan Li#, Jinlan Gao, Liebao Han* and Jin-Long Qiu*. (2022). Simple Bioassay for PAMP-Triggered Immunity in Rice Seedlings Based on Lateral Root Growth Inhibition.Rice Science, 29(1): 67-75.

9.Qiupeng Lin#, Zixu Zhu#, Guanwen Liu#, Chao Sun, Dexing Lin, Chenxiao Xue, Shengnan Li, Dandan Zhang, Caixia Gao, Yanpeng Wang* and Jin-Long Qiu*. (2021). Genome editing in plants with MAD7 nuclease.Journal of Genetics and Genomics, 48(6): 444-451.

10.Qianwei Zhang#, Kangquan Yin#, Guanwen Liu, Shengnan Li, Mengou Li and Jin-Long Qiu*. (2020). Fusing T5 exonuclease with Cas9 and Cas12a increases the frequency and size of deletion at target sites.Science China Life Sciences, 63(12): 1918-1927.

11.Guanwen Liu#, Kangquan Yin#, Qianwei Zhang, Caixia Gao, and Jin-Long Qiu*. (2019). Modulating chromatin accessibility by transactivation and targeting proximal dsgRNAs enhances Cas9 editing efficiencyin vivo.Genome Biology, 20(1):145.

12.Kangquan Yin#and Jin-Long Qiu*. (2019). Genome editing for plant disease resistance: applications and perspectives. Philosophical Transactions of the Royal SocietyB, 374(1767):20180322.

13.Dandan Zhang#, Caijuan Tian#, Kangquan Yin, Wenyi Wang, and Jin-Long Qiu*. (2019). Postinvasive Bacterial Resistance Conferred by Open Stomata in Rice. Molecular Plant-Microbe Interactions, 32(2):255-266.

14.Jingbo Zhang#, Kangquan Yin#, Juan Sun#, Jinlan Gao, Qiuli Du, Huali Li, and Jin-Long Qiu*. (2018). Direct and tunable modulation of protein levels in rice and wheat with a synthetic small molecule.Plant Biotechnology Journal, 16:472-481.

15.Kangquan Yin#, Caixia Gao, and Jin-Long Qiu*. (2017). Progress and prospects in plant genome editing.Nature Plants, 3:17107.

16.Xiang Xiao#, Xi Cheng#, Kangquan Yin, Huali Li, and Jin-Long Qiu*. (2017). Abscisic acid negatively regulates post-penetration resistance of Arabidopsis to the biotrophic powdery mildew fungus.Science China. Life Science, 60:891-901.

17.Shengnan Li#, Wenyi Wang#, Jinlan Gao, Kangquan Yin, Rui Wang, Chengcheng Wang, Morten Petersen, John Mundy, and Jin-Long Qiu*. (2016). MYB75 phosphorylation by MPK4 is required for light-induced anthocyanin accumulation in Arabidopsis.The Plant Cell, 28:2866-2883.

18.Caijuan Tian#, Zhangli Zuo#, and Jin-Long Qiu*. (2015). Identification and characterization of ABA-responsive microRNAs in rice.Journal of Genetics and Genomics, 42: 393-402.

19.Yanpeng Wang#, Xi Cheng#, Qiwei Shan, Yi Zhang, Jinxing Liu, Caixia Gao*,and Jin-Long Qiu*. (2014). Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew.Nature Biotechnology,32: 947-951.

20.Wei Guo#, Chengcheng Wang#, Zhangli Zuo, and Jin-Long Qiu*. (2014). The roles of anion channels in Arabidopsis immunity.Plant Signaling & Behavior, 9(7): e29230.

21.Wei Guo#, Zhangli Zuo, Xi Cheng, Juan Sun, Huali Li, Legong Li, and Jin-Long Qiu*. (2014).The chloride channel family gene CLCd negatively regulates PAMP-triggered immunity in Arabidopsis.Journal of Experimental Botany, 65:1205-1215.

22.Qiwei Shan#, Yanpeng Wang, Jun Li, Yi Zhang, Kunling Chen, Zhen Liang, Kang Zhang, Jinxing Liu, Jianzhong Jeff Xi, Jin-Long Qiu*, and Caixia Gao*. (2013). Targeted genome modification of crop plants using a CRISPR-Cas system.Nature Biotechnology, 31:686-688.

23.Lei Su#, Aining Li#, Huali Li, Chengcai Chu, and Jin-Long Qiu*. (2013). Direct modulation of protein level in Arabidopsis.Molecular Plant, 6:1711-1714.

工作人员

吴杰    女 副研究员wujie@im.ac.cn

赵翠环  女 助理研究员 zhaoch@im.ac.cn

李昂    女 科研财务助理 lia@im.ac.cn

博士后

余敏详   男  博士后

薛天玺   男  博士后

顾  佳   女  博士后    

在读研究生

吕　斌  男  博士生

杜志转  女  博士生            

李雅婷  女  博士生（客座）

苏映月  女  博士生

程婉洁  女  硕士生        

魏婉婷  女  硕士生       

闫思乔  女  硕士生        

程晓彤  女  硕士生（客座）                 

徐泰景文 男  硕士生（客座）                  

已毕业研究生及出站博士后

李爱宁  博士后

郭　葳  博士后

苏　鸓  博士后

韩新运  博士后

张韫玮  博士后

崔　旋  博士后

田彩娟  博 士

李盛楠  博 士

程　曦  博 士

肖　翔  博 士

王文义  博 士

张丹丹  博 士

刘关稳  博 士           

覃　旭  博 士            

梁月婷  博 士            

王曾茜  博 士

张倩伟  博 士

姜丹丹  博 士

伍　粲  硕 士（客座）

左张丽  硕 士

王程程  硕 士

许潇予  硕 士（客座）

王　磊  硕 士（客座）

李晓文  硕 士（客座）

张靖波  硕 士

潘亭亭  硕 士（客座）

王同同  硕 士（客座）

高　庆  硕 士（客座）

陈　巍  硕 士

李盟欧  硕 士           

严  颖  硕 士    

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