围绕医药健康、物质转化及环境保护等重大产业需求，致力于微生物活性天然产物的发现、生物合成机制解析及其代谢途径改造等研究，从分子遗传学和生物化学水平揭示微生物代谢途径中酶催化反应形成复杂多样的天然产物化学结构全过程，推动合成生物学技术在酶工程与天然药物发现及其生物智能制造中的应用，研发新型高效绿色生物催化剂及小分子新药

1.Zhong X, Liu S, Ma B, Gao K, Jiang D, Hou Y, Chen H, Lv J, Bowen JI, Crump MP, Willis CL, Wang L. Genetic engineering of Sorangium cellulosum reveals hidden enzymology in myxobacterial natural product biosynthesis. Nature Communications, 2025,16(1):7996.

2. Bowen JI, Zhong X, Gao K, Reed B, Crump MP, Wang L, Willis CL. Combining total synthesis and genetic engineering to probe dihydropyran formation in ambruticin biosynthesis. Chemical Science, 2024, 15(14):5319-5326.

3. Winter AJ, de Courcy‐Ireland F, Phillips AP, Barker JM, Bakar NA, Akter N, Wang L, Song Z, Crosby J, Williams C, Willis CL, Crump MP. An integrated module performs selective ‘online’ epoxidation in the biosynthesis of the antibiotic mupirocin. Angewandte Chemie International Edition, 2024, 63(49):e202410502.

4. Winter AJ, Khanizeman RN, Barker‐Mountford AM, Devine AJ, Wang L, Song Z, Davies JA, Race PR, Williams C, Simpson TJ, Willis CL, Crump MP. Structure and function of the α‐hydroxylation bimodule of the mupirocin polyketide synthase. Angewandte Chemie International Edition, 2023, 135(47):e202312514.

5. Bowen JI, Wang L, Crump MP, Willis CL. Synthetic and biosynthetic methods for selective cyclisations of 4, 5-epoxy alcohols to tetrahydropyrans. Organic & Biomolecular Chemistry, 2022, 20(6):1150-1175.

6. Bowen JI, Wang L, Crump MP, Willis CL. Ambruticins: tetrahydropyran ring formation and total synthesis. Organic & Biomolecular Chemistry, 2021, 19(28):6210-6215.

7. Wang L, Song Z, Race PR, Spencer J, Simpson TJ, Crump MP, Willis CL. Mixing and matching genes of marine and terrestrial origin in the biosynthesis of the mupirocin antibiotics. Chemical science, 2020,11(20):5221-5226.

8. Walker PD, Williams C, Weir AN, Wang L, Crosby J, Race PR, Simpson TJ, Willis CL, Crump MP. Control of β‐branching in kalimantacin biosynthesis: application of 13C NMR to polyketide programming. Angewandte Chemie International Edition, 2019, 2, 58(36):12446-12450.

9. Wang L, Parnell A, Williams C, Bakar NA, Challand MR, van der Kamp MW, Simpson TJ, Race PR, Crump MP, Willis CL. A Rieske oxygenase/epoxide hydrolase-catalysed reaction cascade creates oxygen heterocycles in mupirocin biosynthesis. Nature Catalysis, 2018, 1(12):968-976.

10. Gao SS, Wang L, Song Z, Hothersall J, Stevens ER, Connolly J, Winn PJ, Cox RJ, Crump MP, Race PR, Thomas CM, Simpson TJ, Willis CL. Selected mutations reveal new intermediates in the biosynthesis of mupirocin and the thiomarinol antibiotics. Angewandte Chemie International Edition. 2017, 56(14):3930-3934.

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