我们的研究是建立在微生物学和有机化学学科交叉的基础上，致力于解析微生物次级代谢产物的合成机制，发掘或通过合成生物学手段创制微生物天然产物药物分子，理解人体微生物次级代谢对健康的影响，在基础研究的推动下发展新型的诊疗手段。

1.Hao T, Xie Z, Wang M, Liu L, Zhang Y, Wang W, Zhang Z, Zhao X, Li P, Guo Z, Gao S, Lou C, Zhang G, Merritt J, Horsman GP, Chen Y*. An anaerobic bacterium host system for heterologous expression of natural product biosyntheticgene clusters. Nature Communications 2019, 10(1):3665.
2.Wei Tang, Zhengyan Guo, Zhenju Cao, Min Wang, Pengwei Li, Xiangxi Meng, Xuejin Zhao, Zhoujie Xie,Wenzhao Wang, Aihua Zhou, Chunbo Lou, and Yihua Chen*. D-Sedoheptulose-7-phosphate is a common precursor for the heptoses of septacidin and hygromycin B. Proc Natl Acad Sci U S A. 2018, 115(11):2818-2823.
3.Zhengyan Guo, Pengwei Li, Guozhu Chen, Chao Li, Zhenju Cao, Yuwei Zhang, Jinwei Ren, Hua Xiang, Shuangjun Lin, Jianhua Ju, Yihua Chen* . Design and biosynthesis of dimeric alboflavusins with biaryl linkages via regiospecific C？C bond coupling. J. Am. Chem. Soc. 2018, 140(51):18009-18015.
4. Nanjaraj Urs AN, Hu Y, Li P, Yuchi Z, Chen Y*, Zhang Y*. Cloning and expression of a nonribosomal peptide synthetase to generate blue rose. ACS Synth Biol. 2018, 8(8):1698-1704.
5. Xie Z, Zhang Z, Cao Z, Chen M, Li P, Liu W, Qin H, Zhao X, Tao Y, Chen Y*. An external substrate-free blue/white screening system in Escherichia coli. Appl Microbiol Biotechnol. 2017, 101(9):3811-3820.
6. Meng X, Wang W, Xie Z, Li P, Li Y, Guo Z, Lu Y, Yang J, Guan K, Lu Z, Tan H, Chen Y*. Neomycin biosynthesis is regulated positively by AfsA-g and NeoR in Streptomyces fradiae CGMCC 4.7387. Sci China Life Sci. 2017, 60(9):980-991.
7. Li J, Wang M, Ding Y, Tang Y, Zhang Z, Chen Y*. Involvement of an octose ketoreductase and two acyltransferases in the biosynthesis of paulomycins. Sci Rep. 2016, 6:21180.
8. Liu L, Hao T, Xie Z, Horsman GP, Chen Y*. Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans. Sci Rep. 2016, 6:37479.
9. Tian J, Chen H, Guo Z, Liu N, Li J, Huang Y, Xiang W, Chen Y*. Discovery of pentangular polyphenols hexaricins A–C from marine Streptosporangium sp. CGMCC 4.7309 by genome mining. Appl Microbiol Biotechnol. 2016, 100(9):4189-99.
10. Guo Z, Li J, Qin H, Wang M, Lv X, Li X, Chen Y*. Biosynthesis of the carbamoylated D-gulosamine moiety of streptothricins: involvement of a guanidino-N-glycosyltransferase and an N-acetyl-D-gulosamine deacetylase. Angew Chem Int Ed Engl. 2015, 54(17):5175-5178.
11. Li P, Li J, Guo Z, Tang W, Han J, Meng X, Hao T, Zhu Y, Zhang L, Chen Y*. An efficient blue-white screening based gene inactivation system for Streptomyces. Appl Microbiol Biotechnol. 2015, 99(4):1923-1933.
12. Haiyan Chen, Ning Liu, Ying Huang, Yihua Chen*. Isolation of an anthrabenzoxocinone 1.264-C from Streptomyces sp. FXJ1.264 and absolute configuration determination of the anthrabenzoxocinones. Tetrahedron: Asymmetry 2014, 25:113-116.
13. Li J, Xie Z, Wang M, Ai G, Chen Y*. Identification and analysis of the paulomycin biosynthetic gene cluster and titer improvement of the paulomycins in Streptomyces paulus NRRL 8115. PLoS One 2015, 10(3):e0120542.
14. Li J, Guo Z, Huang W, Meng X, Ai G, Tang G, Chen Y*. Mining of a streptothricin gene cluster from Streptomyces sp. TP-A0356 genome via heterologous expression. Sci China Life Sci. 2013, 56(7):619-627.

已经培养博士研究生12名，硕士研究生9名，培养相关领域研究员/教授2名，副研究员/副教授6名，助理研究员4名。

1.科技部国家重点研发计划，微生物天然产物的智能创制与改良，2019/07-2024/06
2.国家自然科学基金面上项目，保罗霉素中保罗糖和保罗酸的生物合成机制研究，2017/01-2020/12
3.国家自然科学基金优秀青年科学基金，微生物次级代谢，2016/01-2018/12
4.科技部973计划项目，细菌群体感应通讯系统的网络解析，2015/01-2019/12
5.国家自然科学基金面上项目，链霉菌GB-2 中西索米星与新霉素共合成的代谢机制研究，2014/01-2017/12
6.科技部973计划，合成微生物体系的适配性研究，2013/1-2017/12
7.国家自然科学基金面上项目，链丝菌素类化合物生物合成的研究，2012/01-2015/12