本研究组以模式植物拟南芥、烟草和重要经济作物棉花为寄主材料，以病毒和真菌为病原微生物，围绕植物RNA沉默和miRNA调控途径，以及其他受病原影响的调控途径开展病原微生物－寄主的相互作用研究，剖析植物致病机理。为植物抗病和病害防控提供有效策略。

1.Tian, W.#, Zhang, T.#, Zhao, J. H.#, Dong, Y. M., Li, Y. Z., Zhao, Z. Q., Gao, F., Wu, X. M., Zhang, B. S., Fang, Y. Y., Xie, Z. M.*, Guo, H. S.*(2025) HIGS-mediated crop protection against cotton aphids. Plant Biotechnol J 23(3):692-694.

2. Wu, X. M.#, Zhang, B. S.#, Zhao, Y. L.#, Wu, H. W., Gao, F., Zhang, J., Zhao, J. H.*, Guo, H. S.*(2023) DeSUMOylation of a Verticillium dahliae enolase facilitates virulence by derepressing the expression of the effector VdSCP8. Nat Commun 14(1):4844.

3. Wen, H. G.#, Zhao, J. H.#*, Zhang, B. S., Gao, F., Wu, X. M., Yan, Y. S., Zhang, J., Guo, H. S.*(2023) Microbe-induced gene silencing boosts crop protection against soil-borne fungal pathogens. Nat Plants 9(9): 1409-1418.

4. Zhao, J. H., Guo, H. S.*(2022) RNA silencing: From discovery and elucidation to application and perspectives. J Integr Plant Biol 64(2): 476-498.

5. Chen, Z. Q., Zhao, J. H., Chen, Q., Zhang, Z. H., Li, J., Guo, Z.,Xie, Q., Ding, S. W., Guo, H. S.* (2020)DNA Geminivirus Infection Induces an Imprinted E3 Ligase Gene to Epigenetically Activate Viral Gene Transcription. Plant Cell 32(10), 3256-3272.

6. Wang, S.#, Wu, X.M.#, Liu, C.H., Shang, J.Y., Gao, F., and Guo, H.S.* (2020)Verticillium dahliae chromatin remodeling facilitates the DNA damage repair in response to plant ROS stress. PLoS Pathog16(4), e1008481.

7. Cui, C.#, Wang, J.J.#, Zhao, J.H.#, Fang, Y.Y, He, X.F., Guo, H.S.*, Duan, C.G.*(2020). A Brassica miRNA Regulates Plant Growth and Immunity through Distinct Modes of Action. Molecular Plant13(2): 231-245.

8. Gao, F.#, Zhang, B.S.#, Zhao, J.H., Huang, J.F., Jia, P.S., Wang, S., Zhang, J., Zhou, J.M., Guo, H.S.*（2019）Deacetylation of chitin oligomers increases virulence in soil-borne fungal pathogens. Nature Plants 5(11): 1167-1176.

9. Qin, J., Wang, K., Sun, L., Xing, H., Wang, S., Li, L., Chen, S., Guo, H.S.*, and Zhang, J.* (2018). The plant specific transcription factors CBP60g and SARD1 are targeted by a Verticillium secretory protein VdSCP41 to modulate immunity. eLife 7.

10. Hua,C.L.#, Zhao, J.H.#, and Guo, H.S.* (2018). Trans-kingdom RNA silencing in Plant–Fungal Pathogen Interactions. Mol Plant 11, 235-244.

11. Zhang, L.S.#, Ni, H.#, Du, X., Wang, S., Ma, X.W., Nurnberger, T., Guo, H.S.*, and Hua, C.L.* (2017). The Verticillium-specific protein VdSCP7 localizes to the plant nucleus and modulates immunity to fungal infections. The New phytologist 215, 368-381.

12. Zhou, T.T., Zhao, Y.L., and Guo, H.S.* (2017). Secretory proteins are delivered to the septin-organized penetration interface during root infection by Verticillium dahliae. PLoS pathogens 13, e1006275.

13. Zhang, T., Jin, Y., Zhao, J.H., Gao, F., Zhou, B.J., Fang, Y.Y., and Guo, H.S.* (2016). Host-Induced Gene Silencing of the Target Gene in Fungal Cells Confers Effective Resistance to the Cotton Wilt Disease Pathogen Verticillium dahliae. Mol Plant 9, 939-942.

14. Zhang, T.#, Zhao, Y.L.#, Zhao, J.H.#, Wang, S., Jin, Y., Chen, Z.Q., Fang, Y.Y., Hua, C.L., Ding, S.W., and Guo, H.S.* (2016). Cotton plants export microRNAs to inhibit virulence gene expression in a fungal pathogen. Nature plants 2, 16153.

15. Zhao, Y.L., Zhou, T.T., and Guo, H.S.* (2016). Hyphopodium-Specific VdNoxB/VdPls1-Dependent ROS-Ca2+ Signaling Is Required for Plant Infection by Verticillium dahliae. PLoS pathogens 12, e1005793.

16. Wang, J.J., and Guo, H.S.* (2015). Cleavage of INDOLE-3-ACETIC ACID INDUCIBLE28 mRNA by microRNA847 upregulates auxin signaling to modulate cell proliferation and lateral organ growth in Arabidopsis. The Plant Cell 574-590.

17. Zahid, K.#, Zhao, J.H.#, Smith, N.A., Schumann, U., Fang, Y.Y., Dennis, E.S., Zhang, R., Guo, H.S.*, and Wang, M.B.* (2015). Nicotiana small RNA sequences support a host genome origin of cucumber mosaic virus satellite RNA. PLoS genetics 11, e1004906.

18. Duan, C.G.#, Fang, Y.Y.#, Zhou, B.J., Zhao, J.H., Hou, W.N., Zhu, H., Ding, S.W., and Guo, H.S.* (2012). Suppression of Arabidopsis ARGONAUTE1-mediated slicing, transgene-induced RNA silencing, and DNA methylation by distinct domains of the Cucumber mosaic virus 2b protein. The Plant cell 24, 259-274.

19. Ying, X.B., Dong, L., Zhu, H., Duan, C.G., Du, Q.S., Lv, D.Q., Fang, Y.Y., Garcia, J.A., Fang, R.X., and Guo, H.S.* (2010). RNA-dependent RNA polymerase 1 from Nicotiana tabacum suppresses RNA silencing and enhances viral infection in Nicotiana benthamiana. The Plant cell 22, 1358-1372.

20. Guo, H.S., Xie, Q., Fei, J.F., and Chua, N.H*. (2005). MicroRNA directs mRNA cleavage of the transcription factor NAC1 to downregulate auxin signals for arabidopsis lateral root development. The Plant cell 17, 1376-1386.

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