我们通过揭示休眠细菌的唤醒机制，进而开发对细菌休眠的精准调控策略，或将其唤醒而恢复对抗生素的敏感，或将其永久锁定在休眠状态，进而实现对休眠细菌耐药的有效治疗。另外，我们也基于细菌芽孢抗逆耐药特性，推动芽孢在生物技术领域的智能应用，如作为稳定的酶或疫苗载体，靶向药物递送系统，以及开发工程化芽孢益生菌等。

1. Gao Y, Amon JD, Artzi L, Ramírez-Guadiana FH, Brock KP, Cofsky JC, Marks DS, Kruse AC, Rudner DZ. Bacterial spore germination receptors are nutrient-gated ion channels. Science 380, 387-391, (2023).  
2. Gao Y, Amon JD, Artzi L, Ramírez-Guadiana FH, Cofsky JC, Kruse AC, Rudner DZ. SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination. Genes Dev 38, 31-45 (2024).
3. Gao Y, Barajas-Ornelas RDC, Amon JD, Ramírez-Guadiana FH, Alon A, Brock KP, Marks DS, Kruse AC, Rudner DZ. The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination. Genes Dev 36, 634-646, (2022).

1、国家自然科学基金面上项目，离子通道在休眠细菌芽孢唤醒中的信号感知和转导机制，2026/01-2029/12