研究组主要以水稻、棉花等材料为研究对象，通过研究植物与害虫、病原菌相互作用的机理及植物抗病，抗虫和抗逆等生物技术，为创制优良品种提供策略及技术性指导。

发表论文：
1.Xu L, Tang Y, Zhao G, Zhang Z, Zhang X, Liu W, Peng Q, Wu J. A novel cotton miR7814 targeting GhCNL2 regulates plant defense against Verticillium dahliae infection. Plant Sci. 2025 Oct;359:112604. doi: 10.1016/j.plantsci.2025.112604. Epub 2025 Jun 12. PMID: 40516791.

2.Meng Y, Zhao G, Tang Y, Xu L, Li D, Ge X, Wu J. Ghr-miR166b-GhHB14 Pair With GhDLO1 Partner Mediates Cotton Plant Defence Against Verticillium dahliae. Mol Plant Pathol. 2025 Jun;26(6):e70104. doi: 10.1111/mpp.70104. PMID: 40495269; PMCID: PMC12151801.

3.Wang B, Wang Z, Tang Y, Zhong N, Wu J. Cotton BOP1 mediates SUMOylation of GhBES1 to regulate fibre development and plant architecture. Plant Biotechnol J. 2024 Nov;22(11):3054-3067. doi: 10.1111/pbi.14428. Epub 2024 Jul 14. PMID: 39003587; PMCID: PMC11500983.

4.Wu, P.; Lu, C.;Wang, B.; Zhang, F.; Shi, L.; Xu, Y.; Chen, A.; Si, H.; Su, J.; Wu, J. Cotton RSG2 Mediates Plant Resistance against Verticillium dahliae by miR482b Regulation. Biology 2023, 12, 898. https://doi.org/10.3390/biology12070898

5.Hu G, Ge X, Wang P, Chen A, Li F, Wu J. The cotton miR171a-SCL6 module mediates plant resistance through regulating GhPR1 expression. Plant Physiol Biochem. 2023 Sep;202:107995. doi: 10.1016/j.plaphy.2023.107995. Epub 2023 Aug 30. PMID: 37666042.

6.Guang H, Xiaoyang G, Zhian W, Ye W, Peng W, Linfang S, Bingting W, Anhong Z, Fuguang L, Jiahe W. The cotton MYB33 gene is a hub gene regulating the trade-off between plant growth and defense in Verticillium dahliae infection. J Adv Res. 2023 Aug 28:S2090-1232(23)00233-3. doi: 10.1016/j.jare.2023.08.017. Epub ahead of print. PMID: 37648022.

7.Wen T, Xu X, Ren A, Zhao G and Wu J (2023) Genome-wide identification of terpenoid synthase family genes in Gossypium hirsutum and functional dissection of its subfamily cadinene synthase A in gossypol synthesis. Front. Plant Sci. 14:1162237. doi: 10.3389/fpls.2023.1162237 （入选Faculty Opinions, 原F1000）

8.Tang Y, Zhang ZN, Yang ZY, Wu JH*. (2023) CRISPR/Cas9 and Agrobacterium tumefaciens virulence proteins synergistically increase efficiency of precise genome editing via homology directed repair in plants. Journal of Experimental Botany. erad096 (online), https://doi.org/10.1093/jxb/erad096.

9.Hu G, Wang BT, Jia P, Wu P, Lu CZ, Xu YJ, Shi LF, Zhang FY, Zhong NQ, Chen AM, Wu JH* (2023) The cotton miR530-SAP6 module activated by systemic acquired resistance mediates plant defense against Verticillium dahliae. Plant Science 330 (2023) 111647

10.Zhang Y, Zhang RH, Song Z, Fu WD, Yun LL, Gao JH, Hu G, Wang ZH, Wu HW, Zhang GL* and Wu JH* (2023) Iris lactea var. chinensis plant drought tolerance depends on the response of proline metabolism, transcription factors, transporters and the ROS-scavenging system. BMC Plant Biology, (2023) 23:17

11.Wu J, Wang P and Ge X (2022) Editorial: Identification and functional dissection of stress-responsive genes in cotton. Front. Plant Sci. 13:1008064. doi: 10.3389/fpls.2022.1008064

12.Jia P, Tang Y, Hu G, Quan Y, Chen A, Zhong N, Peng Q* and Wu J* (2022) Cotton miR319b-Targeted TCP4-Like Enhances Plant Defense Against Verticillium dahliae by Activating GhICS1 Transcription Expression. Front. Plant Sci. 13:870882. doi:10.3389/fpls.2022.870882

13.Shi G, Wang S, Wang P, Zhan J, Tang Y, Zhao G, Li F, Ge X* and Wu J* (2022) Cotton miR393-TIR1 Module Regulates Plant Defense Against Verticillium dahliae via Auxin Perception and Signaling. Front. Plant Sci. 13:888703. doi:10.3389/fpls.2022.88870

14.Yang, Z.; Bai, C.; Wang, P.; Fu, W.; Wang, L.; Song, Z.; Xi, X.; Wu, H.; Zhang, G.*; Wu, J*. Sandbur Drought Tolerance Reflects Phenotypic Plasticity Based on the Accumulation of Sugars, Lipids, and Flavonoid Intermediates and the Scavenging of Reactive Oxygen Species in the Root. Int. J. Mol. Sci. 2021, 22, 12615. https://doi.org/10.3390/ijms222312615

15.Wei T, Tang Y, Jia P, Zeng Y, Wang B, Wu P, Quan Y, Chen A, Li Y* and Wu J *. A Cotton Lignin Biosynthesis Gene, GhLAC4, Fine-Tuned by ghr-miR397 Modulates Plant Resistance Against Verticillium dahliae. Front. Plant Sci., 2021, 12:743795. doi: 10.3389/fpls.2021.743795

16.Huang YL, Zhen ZX, Cui Z, Liu JX, Wang SJ, Yang MS*, Wu JH*. Growth and arthropod community characteristics of transgenic poplar 741 in an experimental forest. Industrial Crops and Products, 2021, Volume 162, 113284, ISSN 0926-6690, https://doi.org/10.1016/j.indcrop.2021.113284.

17.Wang ZA, Wang P, Hu G, Xiao JL, Zhang AH, Luo XL* and Wu JH*. Overexpressing rice lesion simulating disease 1-like gene (OsLOL1) in Gossypium hirsutum promotes somatic embryogenesis and plant regeneration. Journal of Cotton Research, 2020. 2020-07-2.（BMC新期刊)

18.Zhao G, Song Y, Wang QH, Yao DX, Li DL, Qin WQ, Ge XY, Yang ZE, Xu WY, Su Z, Zhang XY*, Li FG* and Wu JH*. 2020. Gossypium hirsutum Salt Tolerance Is Enhanced by Overexpression of G. arboreum JAZ1. Fronters in Bioengeering and Biotechnology, 8:157. doi: 10.3389/fbioe.2020.00157. IF=5.122, 2区

19.Hu G #, Hao MY#, Wang L#, Liu JF, Zhang ZN, Tang Y, Peng QZ, Yang ZR*, Wu JH*. 2020. The cotton miR477-CBP60A module participates in plant defence against Verticillium dahlia. Molecular Plant-Microbe Interactions, 33(4), 624–636. doi.org/10.1094/MPMI-10-19-0302-R. IF=3.649, 2区

20.Hu G#, Lei Y#, Liu JF, Hao MY, Zhang ZN, Tang Y, Chen AM, Wu JH*. 2020. The ghr-miR164 and GhNAC100 modulate cotton plant resistance against Verticillium dahlia. Plant Science, 293, 110438. IF=3.785, 2区

21.Zhang ZN, Wang P, Luo XL, Yang CL, Tang Y, Wang ZA, Hu G, Ge XY, Xia GX and Wu JH*. Cotton plant defence against a fungal pathogen is enhanced by expanding BLADE-ON-PETIOLE1 expression beyond lateral-organ boundaries. Communications Biology, 2019, 2: 238. doi.org/10.1038/s42003-019-0468-5.

22.Tang Y, Zhang ZN, Lei Y, Hu G, Liu JF, Hao MY, Peng QZ*, Wu JH*. GhWATs participate in cotton plant resistance against Verticillium dahliae through modulation of SA synthesis and local lignin deposition. Front Plant Sci, 2019, 10:526. IF=4.106, 2区

23.Guo W, Bai C, Wang Z, Wang P, Fan Q, Mi X, Wang L, He J, Pang J, Luo X, Fu W, Tian Y, Si H, Zhang G*, and Wu J*. Double-stranded RNAs high-efficiently protect transgenic potato from Leptinotarsa decemlineata by disrupting juvenile hormone biosynthesis. J Agric Food Chem, 2018, 66: 11990-11999. IF=3.571, 1区

24.Zhang ZN, Ge XY, Luo XL, Wang P, Fan Q, Hu G, Xiao JL, Li FG* and Wu JH*. Simultaneous editing of two copies of Gh14-3-3d confers enhanced transgene-clean plant defense against Verticillium dahliae in allotetraploid upland cotton. Front Plant Sci, 2018, 9: 842. IF=4.4, 2区

25.Wang P, Bai C, Fan Q, Fu WD, Wang L, Zhang ZN, Song Z, Zhang GL*, Wu JH*. Analysis of the role of the DRI15 and SI1 genes in Alternanthera philoxeroides plasticity using a virus-based gene silencing tool. Front Plant Sci, 2017, 8:1579. IF=4.4, 2区

26.Wang L, Wu SM, Zhu Y, Fan Q, Zhang ZN, Hu G, Peng QZ, Wu JH*，Functional characterization of a novel jasmonate ZIM-domain interactor (NINJA) from upland cotton (Gossypium hirsutum). Plant Physiology and Biochemistry, 2017, 112: 152-160. IF=3.404, 2区

27.Zhang GL, Zhu, Fu WD, Wang P, Zhang RH, Zhang YL, Song Z, Xia GX, and Wu JH*. iTRAQ Protein Profile Differential Analysis of Dormant and Germinated Grassbur Twin Seeds Reveals that Ribosomal Synthesis and Carbohydrate Metabolism Promote Germination Possibly Through the PI3K Pathway. Plant and Cell Physiology, 2016, 57: 1244-1256. 5years, IF=5.12, 2区

28.Wang L, Zhu Y, Wang P, Fan Q, Wu Y, Peng Q-Z, Xia G-X, Wu J-H*. Functional Characterization of a Dihydroflavanol 4-Reductase from the Fiber of Upland Cotton (Gossypium hirsutum). Molecules, 2016, 21: 32. IF=3.1, 3区

29.Guo W, Wang Z, Luo X, Jin X, Chang J, He J, Tu E, Tian Y, Si H*, Wu J*. Development of selectable marker-free transgenic potato plants expressing cry3A against the Colorado potato beetle (Leptinotarsa decemlineata Say). Pest Management Science, 2016, 72: 497-504. IF=3.1, 1区

30.Yang C-L, Liang S, Wang H-Y, Han L-B, Wang F-X, Cheng H-Q, Wu X-M, Qu Z-L, Wu J-H*, and Xia G-X*.  Cotton Major Latex Protein 28 Functions as a Positive Regulator of the Ethylene Responsive Factor 6 in Defense against Verticillium dahliae. Molecular Plant, 2015, 8: 399-411. IF=6.534, 1区 (2019 IF=10.812)

31.Wang Z-A, Li Q, Ge X-Y, Yang C-L, Luo X-L, Zhang A-H, Xiao J-L, Tian Y-C, Xia G-X, Chen X-Y, Li F-G*, and Wu J-H*. The mitochondrial malate dehydrogenase 1 gene GhmMDH1 is involved in plant and root growth under phosphorus deficiency conditions in cotton. Scientific Reports, 2015, 5:10343. IF=5.597, 2区.

32.Ge X, Zhang C, Wang Q, Yang Z, Wang Y, Zhang X, Wu Z, Hou Y, Wu J*, and Li F*. iTRAQ Protein Profile Differential Analysis between Somatic Globular and Cotyledonary Embryos Reveals Stress, Hormone, and Respiration Involved in Increasing Plantlet Regeneration of Gossypium hirsutum L.). Journal of Proteome Research, 2015, 14: 268-278. IF=5.02, 1区

33.Zhu Y, Wang H, Peng Q, Tang Y, Xia G, Wu J*, Xie D*. Functional characterization of an anthocyanidin reductase gene from the fibers of upland cotton (Gossypium hirsutum). Planta, 2015, 241: 1075-1089. IF=3.3, 2区

34.Wu J*, Zhu C, Pang J, Zhang X, Yang C, Xia G, Tian Y, and He C*. OsLOL1, a C2C2-type zinc finger protein, interacts with OsbZIP58 to promote seed germination through the modulation of gibberellin biosynthesis in Oryza sativa. The Plant Journal, 2014, 80: 1118-1130. IF=6.963, 1区.

35.Pang Jinhuan, Zhu Yue, Li Qing, Liu Jinzhi, Tian Yingchuan, Liu Yule, Wu Jiahe*. Development of Agrobacterium-Mediated Virus-Induced Gene Silencing and Performance Evaluation of Four Marker Genes in Gossypium barbadense. PLoS ONE, 2013, 8(9): e73211. (5Y IF=4.7, 2区)

36.Luo Xiaoli, Wu Jiahe*, Li Yuanbao, Nan Zhirun, Guo Xing, Wang Yixue, Zhang Anhong, Wang Zhian, Xia Guixian, Tian Yingchuan*.   HYPERLINK "http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054002" \o "Read Open-Access Article"  Synergistic Effects of GhSOD1 and GhCAT1 Overexpression in Cotton Chloroplasts on Enhancing Tolerance to Methyl Viologen and Salt Stresses . PLoS ONE, 2013, 10.1371/journal.pone. e54002. IF=4.7, 2区

37.Zhou Zhaoxu, Pang Jinhuan, Guo Wenchao, Zhong Naiqing, Tian Yingchuan, Xia Guixian, Wu Jiahe*. Evaluation of the resistance of transgenic potato plants expressing various levels of Cry3A against the Colorado potato beetle (Leptinotarsa decemlineata Say) in laboratory and field. Pest Management Science, 2012, 68: 1595–1604. IF=2.863, 1区

38.Zhu Chuanfeng, Wang Yixue, Li Yuanbao, Bhatti KH, Tian Yingchuan, and Wu Jiahe*. Overexpression of a cotton cyclophilin gene (GhCyp1) in transgenic tobacco plants confers dual tolerance to salt stress and Pseudomonas syringae pv. tabaci infection. Plant Physiology and Biochemistry, 2011, 149: 1264-1271. IF=3.330, 2区

39.Wu Jiahe*, Luo Xiaoli, Zhang Xiangrong, Shi Yuejing, and Tian Yingchuan*. Development of insect-resistant transgenic cotton with chimeric TVip3A* accumulating in chloroplasts. Transgenic Research, 2011, 20: 963-973. (IF=2.208)

40.Yang Xing, Zhang Xiangrong, Zhang Mingju, Guo Wenchao, Tian Yingchuan, Xia Qizhong, Wu Jiahe*. Transgenic potato (Solanum tuberosum) overexpressing the Amaranthus caudatus agglutinin gene to confer aphid resistance. Crop Science, 2011, 51: 2119-2124. (IF=2.02）

41.Wu Jiahe, Luo Xiaoli, Wang Zhian, Tian Yingchuan, Liang Aihua, Sun Yi. Transgenic cotton expressing synthesized scorpion insect toxin AaHIT gene confers enhanced resistance to cotton bollworm (Heliothis armigera) larvae. Biotechnology Letter, 2008，30: 547–554.（IF=1.838）

42.Wu Jiahe, Luo Xiaoli, Guo Hongnian, Xiao Juanli, and Tian Yingchuan. Transgenic cotton (Gossypium hirsutum L.) expressing Amaranthus caudatus agglutinin confers enhanced resistance to aphids. Plant breeding, 2006, 125: 390-394.（IF=1.486）

43.Wu Jiahe, Zhang Xianlong, Nie Yichun, Luo Xiaoli. High-efficiency transformation of Gossypium hirsutum embryogenic calli mediated by Agrobacterim tumefaciens and regeneration of insect- resistant plants. Plant breeding, 2005, 124: 142 -147.（IF=1.486）

44.Wu Jiahe, Zhang Xianlong, Nie Yichun, Jin Shuangxia, Liang Shaoguang. Factors affecting somatic embryogenesis and plant regeneration from a range of recalcitrant genotypes of Chinese cotton. In Vitro Cell Dev Biol –Plant, 2004, 40: 371–375. (IF=1.535)

专利：

1．吴家和，田颖川. 2011，获得授权专利《一种培育抗虫植物的方法及其专用蛋白和基因》，专利公开号：ZL 2008 1 0057662.7。（200万元转让）

2．吴家和，庞金环，王江英，夏桂先，田颖川. 2014，获得授权专利《 一种培育抗逆植物的方法及其专用蛋白和基因》，专利公开号：ZL 2012 1 0042222.0

3．吴家和，庞金环，夏桂先. 2016, 获得授权专利《一种培育抗性植物的方法及其专用蛋白和基因》。ZL 2012 1 0506489.0

4．吴家和，王鹏，范强，王乐. 2016，获得授权专利《一种与植物抗病性和器官脱落相关的蛋白及其编码基因和应用》，专利号：ZL 2016 1 0349015.8，申请日：2016.05.24，公告日：2020.08.11，公告号：CN 107417776 B。

5．吴家和，胡广. 2017，获得授权专利《一种人工合成的植物抗虫蛋白及其制备方法和应用》，专利号：ZL 2017 1 1015769.0。申请日：2017.10.25，授权公告日：2019.12.10，授权公告号：CN 107573410 B.

6．吴家和，陈爱民，刘建芬，胡广，姜辉. 获得授权专利《植物抗病蛋白GhWRKY40与编码基因及其应用》，专利号：ZL 2019 1 0690409.3，专利申请日：2019.07.29，公告日：2021.04.20，公告号：CN 110256549 B.

7．吴家和，胡广. 2023，获得授权专利《一种人工合成的抗除草剂蛋白》，专利号：ZL 2020 1 1197898.5. 专利申请日：2020.10.29，授权公告日：2023.02.03，授权公告号：CN 112266419 B

在读研究生：

唐叶    博士研究生  中国科学院微生物研究所

张小琼  硕士研究生  郑州大学

许梓腾  硕士研究生  甘肃农业大学

单雯    硕士研究生  吉首大学

何玉凤  硕士研究生  吉首大学

孙大智  硕士研究生  宁夏大学

已毕业成员：

张振楠  博士研究生  河南大学

胡广    博士研究生  中国农业科学院棉花研究所

王炳婷  硕士研究生  中国科学院微生物研究所

李元宝  硕士研究生  甘肃农业大学

王鹏    硕士研究生  甘肃农业大学

雷煜    硕士研究生  甘肃农业大学

武盼    硕士研究生  甘肃农业大学

张飞燕  硕士研究生  甘肃农业大学

张晓宁  硕士研究生  甘肃农业大学

曾焱明  硕士研究生  吉首大学

贾培    硕士研究生  吉首大学

陆承哲  硕士研究生  吉首大学

石琳芳  硕士研究生  吉首大学

徐嘉妤  硕士研究生  吉首大学

许云姣  硕士研究生  山西农业大学

徐林    硕士研究生  郑州大学

1.科技创新2030—重大项目，子课题《抗虫高产杨树新品种设计与培育》2022ZD0401502，2022.7—2025.12

2.国家重点研发计划，子课题《棉花重要性状基因资源挖掘与利用》2022YFD1200007，2022.12—2027.12

3.国家自然科学基金委员会, 《GhWRKY28-like蛋白磷酸化和泛素化协同调控棉花对黄萎病的抗性》，32272117，2023-2026

4.国家重点研发计划，《林业种质资源培育与质量提升》，2021YFD2200103-07，2021-2026

5.国家自然基金，《GhBOP1翻译后修饰精细调控棉花生长发育和抗病性之间相互转换》，31971905，2020-2023

6.国家转基因重大专项，《新型抗虫基因vip3A和GM克隆及棉花材料创制》， 2018ZX080009-01B，2018-2020

7.中国科学院与新疆九圣禾种业有限公司横向合作课题，《抗旱、抗盐等抗逆棉花的培育》，250万元，2018-2023

8.国家自然基金，《GhWRKY28和GhWRKY28-like共同调控棉花对大丽轮枝菌的抗性反应》， 31771848，2018-2021

9.国家重点研发计划子课题，《黄河流域高效轻简化棉花新品种培育》，2018YFD0100301，2018-2020

10.国家转基因重大专项子课题，《转Bt基因107杨等抗虫新品种培育》，2018ZX08020002-002-001，2018-2020

11.国家转基因专项子课题，《棉花优质纤维基因的挖掘及分子改良》，2016ZX08005-003-002，2016-2020

12.国家自然基金，《棉花GhBOP1调控蕾铃离层形成发育的分子机制研究》， 31471544，2015-2018

13.中国科学院科技支新工程，《稻水象甲的生物防治及其促进伊犁有机稻米生产》， 2014-2015，CAS-XJ-B02

14.横向课题（武汉惠华三农种业有限公司合作）--专利转让，《一种培育抗虫植物的方法及其专用蛋白和基因》，200万元，2013-2028

15.国家自然基金，《棉花GhBOP1对蕾铃离层形成发育的调控机理研究》，31271773，2012-2013

16.国家公益性行业科研专项子课题，《马铃薯甲虫持续防控技术研究与示范》，201103026-2，2011-2015

17.中国科学院院地合作，《转Bt-S1m和vip3A抗虫基因玉米的培育》，XBXJ-2010-003，2010-2013

18.国家转基因专项子课题，《新型抗虫基因棉花材料创造与新品系培育》，2009ZX08010-004，2009-2011

19.国家“863”，《一个水稻株高调控基因的功能研究及其在株型设计上的应用》， 2008AA10Z104，2008-2010

20.国家转基因专项子课题，《棉花规模化转基因技术体系构建》， 2008ZX08010-004，合作主持，2008-2010

21.国家公益性行业科研专项课题，《马铃薯甲虫持续防控技术研究与示范》，200803024，2008-2010

22.横向课题（北京大北农科技集团有限责任公司合作）--专利转让，《抗虫转基因水稻和玉米的培育》，300万元，2007-2021

23.国家自然基金，《水稻OsLSD1基因对细胞程序性死亡的调控机理及其受光诱导启动子的研究》，30571055，2006-2008

24.国家科技部攻关，《两个抗病信号调节基因在棉花中的表达及其对棉花抗病性的影响》，2005BA530C，2005-2008

25.新疆自治区支疆项目（合作主持），《马铃薯甲虫“自毁”基因鉴定和抗虫马铃薯培育》， 2013911091，2013-2015

26.棉花生物学国家重点实验室开放课题，《陆地棉中原花青素生物合成ANR途径鉴定》，CB2014B02，2015-2016；棉花生物学国家重点实验室开放课题，《棉花转录因子GhWRKY4基因的抗逆功能分析》， CB2014B02，2014-2015；棉花生物学国家重点实验室开放课题，《棉花GhCyt b5耐逆功能分析及其在育种设计上应用》， CB2013B03，2013-2014

27.国家转基因专项子课题，《品质优良的纤维的转抗病虫、抗除草剂棉花品系的选育》， JY03B06，2003-2006

28.国家转基因专项子课题，《棉花外源基因规模化转化及生物技术育种体系的研究与建立》， Joo-B-002-1-12，2002-2005

29.国家“十五”“863”子课题，《棉花转基因技术平台优化育种》，2001AA212081，2001-2004

30.山西青年基金，《抗病双价基因的棉花转化和表达机制的研究》，20101042，2010-2012

31.山西省科技攻关项目，《转耐盐碱调控基因Cyclophilin棉花的获得及其抗盐碱棉花材料的创造》，20080311003-2，2008-2010

32.山西省科技攻关项目《双价抗病基因的克隆、构建和转基因抗病棉花中的研制》041001-1，2004-2006

33.山西省科技攻关项目，《棉花抗黄病相关基因片段筛选及基因克隆》，042005，2004-2006