正高级专业技术人员
林啸
林啸  博士、研究员 、博士生导师
研究方向:

卵菌基因组学和宿主免疫机制

电话/传真:+86 10 64807645
电子邮件:xiao.lin@im.ac.cn
通讯地址:北京市朝阳区北辰西路1号院3号

教育经历

2013.9-2018.10 荷兰Wageningen大学,博士
2010.09-2013.07 华中农业大学, 园艺林学学院,基因组,农学硕士   
2006.09-2010.07 华中农业大学, 生命科学学院, 生物科学理科基地班, 生物学学士

工作经历

2018-2023 英国The Sainsbury Laboratory,博士后

2023-至今 中国科学院微生物研究所,研究员

研究领域

卵菌(Oomycete),尤其是疫霉属(Phytophthora)的病原微生物在农业上会造成巨大的经济损失,比如马铃薯晚疫病、烟草黑胫病、辣椒疫病、橡树猝死病、大豆根腐病等。为了发掘更多卵菌的抗性基因,研究组将收集、评价作物的近缘或者远缘野生物种,并将病原效应子作为工具,在野生植物中寻找新的植物抗病基因,同时深入研究植物免疫和植物病原互作的分子机制,最终利用这些资源和知识培育出更加抗病的农作物。

代表成果

1.Lin, X.#*, Jia, Y#., Heal, R., Prokchorchik, M., Sindalovskaya, M., Olave-Achury, A., et al. (2023). Solanum americanum genome-assisted discovery of immune receptors that detect potato late blight pathogen effectors. Nature Genetics, 55: 1579–1588.

2.Ahn, H.K.#, Lin, X#., Olave-Achury, A.C., Derevnina, L., Contreras, M.P., Kourelis, J., Kamoun, S. and Jones, J.D.G. (2023) Effector-dependent activation and oligomerization of NRC helper NLRs by Rpi-amr3 and Rpi-amr1. The EMBO Journal. (Co-first author)

3.Lin X, Olave-Achury A, Heal R, Witek K, Karki HS, Song T, Wu CH, Adachi H, Kamoun S, Vleeshouwers VGAA, Jones JDG (2022) A potato late blight resistance gene protects against multiple Phytophthora species by recognizing a broadly conserved RXLR-WY effector. Molecular Plant. Doi: https://doi.org/10.1016/j.molp.2022.07.012

4.Witek K#, Lin X#, Karki HS#, Jupe F, Witek AI, Steuernagel B, Stam R, van Oosterhout C, Fairhead S, Cocker JM, Bhanvadia S, Barrett W, Wu C-H, Adachi H, Song T, Kamoun S, Vleeshouwers VG, Tomlinson L, Wulff BB, Jones JDG (2021) A complex non-host resistance locus in Solanum americanum recognizes a conserved Phytophthora effector. Nature plants. 7, 198-208 (Co-first author)

5.Lin X, Wang S, de Rond L, Bertolin N, Wouters RHM, Wouters D, Domazakis E, Bitew MK, Win J, Dong S, et al (2020) Divergent Evolution of PcF/SCR74 Effectors in Oomycetes Is Associated with Distinct Recognition Patterns in Solanaceous Plants. MBio 11: 380

6.Lin X, Armstrong M, Baker K, Wouters D, Visser RGF, Wolters PJ, Hein I, Vleeshouwers VGAA. (2020). RLP/K enrichment sequencing; a novel method to identify receptor-like protein (RLP) and receptor-like kinase (RLK) genes. New Phytologist 227:1264-1276

7.Lin X, Song T, Fairhead S, Witek K, Jouet A, Vleeshouwers VGAA, Hein I, Jones JDG (2020) Identification of Avramr1 from Phytophthora infestans using long read and cDNA pathogen-enrichment sequencing (PenSeq). Molecular Plant Pathology. 00:1-12. doi: https://doi.org/10.1111/mpp.12987

8.X Lin*, JDG Jones* (2020) RNA Splicing: A Novel Pathogen Effector Target. Molecular Plant. 13 (10), 1348

9.Xiao Lin, Yu Zhang, Hanhui Kuang and Jiongjiong Chen (2013) Frequent loss of lineages and deficient duplications accounted for low copy number of disease resistance genes in Cucurbitaceae. BMC genomics 14:335   

承担科研项目情况

1、国家自然科学基金面上项目,马铃薯晚疫病菌效应子S04373的免疫抑制机制和受体设计,2024/01-2027/12      

2、国家自然科学基金生物育种基础研究青年专项,从野生植物中克隆新马铃薯晚疫病抗病基因,2025/01-2029/12