以光合自养菌蓝藻为研究材料，从分子生理学及代谢工程角度探索提高光合固碳效率的新策略；开发蓝藻遗传操作工具；开发光合固碳产化学品平台。

1.Zhang Wei#, Zhou Jie#*, Zhang Yanping, Li Yin*. Metabolic engineering of a high-light tolerant cyanobacterium Synechocystis sp. PCC 6803 for efficient biosynthesis of β-farnesene from CO2. Systems Microbiology and Biomanufacturing, 2025, doi.org/10.1007/s43393-025-00391-y.

2. Meng Hengkai, Zhang Wei, Zhu Huawei, Yang Fan, Zhang Yanping, Zhou Jie*, Li Yin*. Over-expression of an electron transport protein OmcS provides sufficient NADH for D-lactate production in cyanobacterium. Biotechnology for Biofuels, 2021, 14(1): 0-109

3. Zhou Jie, Yang Fan, Zhang Fuliang, Meng Hengkai, Zhang Yanping, Li Yin. Impairing photorespiration increases photosynthetic conversion of CO2 to isoprene in engineered cyanobacteria. Bioresources and Bioprocessing, 2021, 8(1): 0-42.

4. Yang Fan, Zhang Junli, Cai Zhen, Zhou Jie*, Li Yin*. Exploring the oxygenase function of Form II Rubisco for production of glycolate from CO2, AMB Express, 2021, 11(1): 0-65.

5. Hu Guipeng#, Zhou Jie#, Chen Xiulai, Qian Yuanyuan, Gao Cong, Guo Liang, Xu Peng, Chen Wei, Chen Jian, Yin Li, Liu Liming. Engineering synergetic CO2-fixing pathways for malate production. Metabolic Engineering, 2018, 47: 496–504.

6. Zhou Jie, Zhang Fuliang, Meng Hengkai, Zhang Yanping, Li Yin. Introducing extra NADPH consumption ability significantly increases the photosynthetic efficiency and biomass production of cyanobacteria. Metabolic Engineering, 2016, 38(8): 217-227.

7. Zhou Jie, Zhu Taicheng, Cai Zhen, Yin Li. From cyanochemicals to cyanofactories: a review and perspective, Microbial Cell Factories, 2016, 15 (2).

8. Zhou Jie, Zhang Fuliang, Meng Hengkai, Bao Guanhui, Zhang Yanping, Li Yin. Development of a silicon carbide disruption method enables efficient extraction of proteins from cyanobacterium Synechocystis sp. PCC 6803. Process Biochemistry，2014, 49: 2199-2202.

9. Zhou Jie, Zhang Fuliang, Meng Hengkai, Zhang Yanping, Li Yin. Production of optically pure D-lactate from CO2 by blocking the PHB and acetate pathways and expressing D-lactate dehydrogenase in cyanobacterium Synechocystis sp. PCC 6803，Process Biochemistry. 2014, 49: 2071-2077.

10. Zhou Jie, Zhang Fuliang, Meng Hengkai, Zhu Yan, Bao Guanhui, Zhang Yanping, Li Yin, Ma Yanhe. Discovery of a super-strong promoter enables efficient production of heterologous proteins in cyanobacteria, Scientific Reports, 2014, (4500).

11. Zhou Jie, Zhang Haifeng, Zhang Yanping, Li Yin, Ma Yanhe. Designing and creating a modularized synthetic pathway in cyanobacterium Synechocystis enables production of acetone from carbon dioxide, Metabolic Engineering, 2012, 14(3): 394-400.

12. Zhou Jie, Yin Li. Engineering cyanobacteria for fuels and chemicals production. Protein Cell, 2010, 1: 207-210.

1.硕博生，张伟，2014-2022，《耐受高光的速生集胞藻6803的分子生理学研究》

2. 博士生，杨帆，2016-2021，《提高蓝藻CO2利用效率的研究》

3. 博士生，张福良，2011-2016，《提高蓝藻光合效率的辅因子扰动新策略及其生理影响研究》

4. 硕博生，蒙恒凯，2011-2018，《利用CO2生物合成光学纯D-乳酸的科学问题研究》

5. 硕士生，解鹃， 2007-2010，《阻断PHB合成代谢工程改造集胞藻的建立及其应用研究》

1、科技部国家重点研发计划专项项目子课题, JMRH-2020-15-001-02, 基于元件理性设计的高效合成法尼烯光自养微生物细胞工厂的构建, 2020/12-2023/12

2、国家合成生物技术创新中心(中国科学院天津工业生物技术研究所)子任务，TSBICIP-KJGG-007，光电转换功能模块的研发，2020/07-2023/07

3、国家自然科学基金面上项目，31670048，引入ATP和NADPH消耗能力以减弱光呼吸、提高光合固碳效率的新策略及其生理影响研究，2017/01-2020/12

4、中国科学院重点部署项目二氧化碳生物转化子课题，ZDRW-ZS-2016-3E，宽光谱利用及强光驱动二氧化碳转化：异戊二烯，2016/01-2018/12

5、中国科学院战略性先导科技专项（A类）项目子课题，XDA07040400，二氧化碳生物制聚合材料单体D-乳酸的关键技术，2014/01-2016/12

6、科技部“973”项目人工合成细胞工厂子课题，2011CBA00803，光合蓝细菌细胞工厂改造，2011/01-2015/08

7、国家自然科学基金面上项目，30970103，蓝藻腺苷酸环化酶和磷酸二酯酶对环境中无机碳、氮的响应机制研究，2010/01-2012/12

8、国家自然科学基金面上项目青年基金，30500108，蓝藻谷氨酰胺酶的生物学功能及其对碳酸氢盐的响应，2006/01-2009/12