聚焦于病原菌与噬菌体的互作研究，揭示细菌抵御噬菌体侵染以及噬菌体反制细菌防御的防御-反防御机制

1. Mu Y#, Song Y#, Tian X, Ding Z, Yao S, Li Y, Wang C, Wei D, Vollmer W, Zhang G*, Feng J*. Leveraging collateral sensitivity to counteract the evolution of bacteriophage resistance in bacteria. mLife. 2025 Mar 18;4(2):143-154.

2. Yao S#, Wu X#, Li Y, Song Y, Wang C, Zhang G*, Feng J*. Harnessing the Native Type I-F CRISPR-Cas System of Acinetobacter baumannii for Genome Editing and Gene Repression. Int J Antimicrob Agents. 2023 Nov;62(5):106962.

3. Zhang Gang#, Yao Shigang#, Liu Yunan, Fang Hailing, Song Yuqin, Wang,Chao Wei Dawei, Jie Feng*. Systematic discovery of a new catalogue of tyrosine-type integrases in bacterial genomic islands. Appl Environ Microbiol. 2023 Feb 28;89(2):e0173822.

4. Yao Shigang, Wei Dawei, Tang Na, Song Yuqin, Wang Chao, Feng Jie*, Zhang Gang*. Efficient suppression of natural plasmid-borne gene expression in carbapenem-resistant Klebsiella pneumoniae using a compact CRISPR interference system. Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0089022.

5. Zhang Gang#, Li Jianjuan#, Ai Guomin, He Jialiang, Wang Chao*, Feng Jie*. A new intrinsic aminoglycoside 6'-N-acetyltransferase subclass, AAC(6')-III, in Burkholderia pseudomallei, Burkholderia mallei, and Burkholderia oklahomensis. J Antimicrob Chemother. 2020 May 1;75(5):1352-1353.

6. Zhang Gang, Sun Kaiwen, Ai Guomin, Li Jianjuan, Tang Na, Wang Chao*, Feng Jie*. A novel family of intrinsic chloramphenicol acetyltransferase CATC in Vibrio parahaemolyticus: naturally occurring variants reveal diverse resistance levels against chloramphenicol. Inter J Antimicrob Agents. 2019 Jul;54(1):75-79.

7. Tian Jingjing#, Zhang Gang#, Ju Yingjiao, Tang Na, Li Jianjuan, Jia Rufu, Feng Jie*. Five novel carbapenem-hydrolyzing OXA-type β-lactamase groups are intrinsic in Acinetobacter spp. J Antimicrob Chemother. 2018, 73(12):3279-84.

8. Zhang Gang, Leclercq Sebastien Olivier, Tian Jingjing, Wang Chao, Yahara Koji, Ai Guomin, Liu Shuangjiang, Feng Jie*. A new subclass of intrinsic aminoglycoside nucleotidyltransferases, ANT(3")-II, is horizontally transferred among Acinetobacter spp. by homologous recombination. PLoS Genet. 2017, 13(2): e1006602.

9. Zhang Gang, Tian Jingjing, Wang Chao, Chen Jifeng, Feng Jie*. Identification of novel cryptic aminoglycoside phosphotransferases in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2016, 60(11):6983-5.

10. Zhang Gang, Wang Chao, Sui Zhihai, Feng Jie*. Insights into the evolutionary trajectories of fluoroquinolone resistance in Streptococcus pneumoniae. J Antimicrob Chemother. 2015, 70(9): 2499-506.

1.科技部，国家重点研发计划合成生物学专项，治疗型噬菌体的人工设计与构建2024YFA0919400，2024-12至2029-11，（课题骨干）

2. 国家重点研发计划, 多重耐药食源性病原菌溯源及其耐药基因传播预警， 2022YFC2303900, 2022/12-2025/11. (子课题负责人）

3. 国家自然科学基金面上基金，重组酶Iscr2和ResG协同介导耐药元件iscr2-sul2的移动机制研究，主持，32070075，2021.01-2024.12

4. 国家自然科学基金青年项目，病原细菌中转移酶固有耐药组的发现及其进化研究，主持，31500061, 2016.01-2018.12