人才队伍
刘宁
刘宁  博士、 高级工程师 、硕士生导师
研究方向:

微生物天然产物开发

电话/传真:+86(10)64807436
电子邮件:fussliu@126.com
通讯地址:北京市朝阳区北辰西路1号院3号

教育经历

1999-09 至 2003-07, 北京化工大学, 生物工程, 学士
2004-09 至 2007-06, 中国科学院微生物研究所, 微生物学, 硕士
2015-09 至 2021-06, 中国科学院大学, 遗传学, 博士

工作经历

2007-09 至 2011-04, 中国科学院微生物研究所, 微生物资源前期开发国家重点实验室, 助理工程师

2011-05 至 2016-09, 中国科学院微生物研究所, 微生物资源前期开发国家重点实验室, 工程师

2016-10 至 今, 中国科学院微生物研究所, 微生物资源前期开发国家重点实验室, 高级工程师

研究领域

致力综合运用微生物学和天然产物化学技术,从放线菌中发掘或者创制新颖次级代谢产物,解析其生理生态活性及生物合成机制,开发新颖具有成药价值的化学小分子。

代表成果

1.Liang Lu; Ning Liu; Zihui Fan; Minghao Liu; Xiaxia Zhang; Juan Tian; Yanjun Yu; Honghui Lin; Ying Huang; Zhaosheng Kong. A novel PGPR strain Streptomyces lasalocidi JCM 3373 alleviates salt stress and shapes root architecture in soybean by secreting indole-3-carboxaldehyde. Plant Cell & Environment 2024 47(6): 1941-1956

2. Wang Kairui; Liu Ning; Liu Minghao; Zhao Pan; Zhong Naiqin; Challis Gregory L.; Huang Ying. Discovery and Biosynthesis of Streptolateritic Acids A-D: Acyclic Pentacarboxylic Acids from Streptomyces sp. FXJ1.172 with Promising Activity against Potato Common Scab. J Agric Food Chem 2024 72(26): 14760-14768

3. Xueyuan Du; Ning Liu; Bingfa Yan; Yisong Li; Minghao Liu; Ying Huang. Proximity-based defensive mutualism between Streptomyces and Mesorhizobium by sharing and sequestering iron. ISME J 2024 18(1):wrad041

4. Ning Liu; Yang Xu; Fei Shang; Huiying Sun; Xiang Liu; Ying Huang; Huarong Tan; Jihui Zhang. New insights into the dihydro-mureidomycin biosynthesis controlled by two unusual proteins in Streptomyces roseosporus. Microb Cell Fact 2023 22(1): 255-269

5. Jiao Huang; Guomin Ai; Ning Liu*; Ying Huang*. Environmental Adaptability and Organic Pollutant Degradation Capacity of a Novel Rhodococcus Species Derived from Soil in the Uninhabited Area of the Qinghai-Tibet Plateau. Microorganisms 2022 1(10): 1935

6. Bingfa Yan; Ning Liu; Minghao Liu; Xueyuan Du; Fei Shang; Ying Huang. Soil actinobacteria tend to have neutral interactions with other co-occurring microorganisms especially under oligotrophic conditions. Environ Microbiol 2021 23(8): 4126-4140.

7. Ning Liu; Hanye Guan; Guoqing Niu; Lingjuan Jiang; Yue Li; Jihui Zhang; Jine Li; Huarong Tan. Molecular mechanism of mureidomycin biosynthesis activated by introduction of an exogenous regulatory gene ssaA into Streptomyces roseosporus. Sci China Life Sci 2021 64(11): 1949-1963

8. Fangying Song; Ning Liu; Minghao Liu; Yihua Chen; Ying Huang. Identification and Characterization of Mycemycin Biosynthetic Gene Clusters in Streptomyces olivaceus FXJ8.012 and Streptomyces sp FXJ1.235. Mar Drugs 2018 3(16): 98

9. Ning Liu; Lijiang Song; Minghao Liu; Fei Shang; Zoe Anderson; David J. Fox; Gregory L. Challis; Ying Huang. Unique post-translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264. Chem Sci 2016 7(1): 482-488.

10. Liu Ning; Song Fangying; Shang Fei; Huang Ying. Mycemycins A-E New Dibenzoxazepinones Isolated from Two Different Streptomycetes. Mar Drugs 2015 13(10): 6247-6258.

11. Chen Haiyan; Liu Ning; Huang Ying; Chen Yihua. Isolation of an anthrabenzoxocinone 1.264-C from Streptomyces sp FXJ1.264 and absolute configuration determination of the anthrabenzoxocinones. Tetrahedron: Asymmetry 2014 25(2): 113-116.

12. Ning Liu; Fei Shang; Lijun Xi; Ying Huang. Tetroazolemycins A and B two new oxazole-thiazole siderophores from deep-sea Streptomyces olivaceus FXJ8.012. Mar Drugs 2013 11(5): 1524-1533

13. Wang Hao; Liu Ning; Xi Lijun; Rong Xiaoying; Ruan Jisheng; Huang Ying. Genetic Screening Strategy for Rapid Access to Polyether Ionophore Producers and Products in Actinomycetes. Appl Environ Microbiol 2011 77(10): 3433-3442

14. Liu Ning; Wang Haibin; Liu Mei; Gu Qiang; Zheng Wen; Huang Ying. Streptomyces alni sp nov. a daidzein-producing endophyte isolated from a root of Alnus nepalensis D. Don. Int J Syst Evol Microbiol 2009 59: 254-258


承担科研项目情况

1、企业技术服务项目,红色诺卡氏菌细胞壁骨架 (Nr-CWS) 生产菌种主种子批及工作种子批制备,2023-HX2-021,2023/04- 2024/12

2、研究所自主部署项目,卤化酶基因在链霉菌次级代谢产物开发中的应用(续),E3FJ2301,2023/07-2025/06

3、研究所自主部署项目,卤化酶基因在链霉菌次级代谢产物开发中的应用,E1FJ2301,2021/07- 2023/06

4、国家自然科学基金面上基金,嗜酸放线菌活性新骨架化合物的挖掘及其生物合成研究,81773615,2018/01-2021/12

5、国家自然科学基金青年基金,H+、Fe3+介导的红壤嗜酸放线菌活性、"隐性"抗生素资源研究,31300010,2014/01-2016/12