主要研究方向为甲基营养型酵母的系统生物学及合成生物学，通过对毕赤酵母细胞工厂的改造重构，成功实现转化一碳原料生产多种重要工业酶制剂、疫苗及高附加值化学品。

1.Wang, Shuxian, Jiayu Fang, Meiyu Wang, Sijie Yu, Yan Xia, Guoxia Liu, Yanping Zhang, Yin Li, Taicheng Zhu*. “Rewiring the Methanol Assimilation Pathway in the Methylotrophic Yeast Pichia pastoris for High-Level Production of Erythritol.” Bioresource Technology, 427: 132430.

2.Wang, Shuxian, Jiayu Fang, Yanping Zhang, Yin Li*, Taicheng Zhu*. “Engineering Methylotrophic Yeasts as Cell Factories for Chemical Production Using Methanol as a Feedstock.” GCB Bioenergy, 17(8): e70068.

3.Zhao, Xinyu, jiayu Fang, Sijie Yu, Guoxia Liu, Yanping Zhang, Yin Li, Taicheng Zhu*. “Hac1p-Based Inverse Secretory Pathway Engineering (Hi-SPE) of Pichia pastoris for Improved Glucose Oxidase Production.” New Biotechnology, 89: 82–90.

4.Zhao, Tongxin, Sheng Liu, Pengyan Wang, Yanfang Zhang, Xinrui Kang, Xiaoqian Pan, Linjie Li, Dedong Li, Ping Gao, Yaling An, Hao Song, Kefang Liu, Jianxun Qi, Xin Zhao, Lianpan Dai, Peipei Liu*, Peiyi Wang, Guizhen Wu, Taicheng Zhu*, Kun Xu*, Yin Li, George F. Gao. “Protective RBD-Dimer Vaccines against SARS-CoV-2 and Its Variants Produced in Glycoengineered Pichia pastoris.” PLOS Pathogens, 20(8): e1012487.

5.Fang, Jiayu, Yanping Zhang, Taicheng Zhu*, Yin Li*. “Scramblase Activity of Proteorhodopsin Confers Physiological Advantages to Escherichia coli in the Absence of Light.” iScience, 26(12): 108551.

6.Miao, Liangtian, Yin Li*, Taicheng Zhu*. “Metabolic Engineering of Methylotrophic Pichia pastoris for the Production of β-Alanine.” Bioresources and Bioprocessing, 8(1): 89.

7.Yu, Sijie, Liangtian Miao, He Huang*, Yin Li, Taicheng Zhu*. “High-Level Production of Glucose Oxidase in Pichia pastoris: Effects of Hac1p Overexpression on Cell Physiology and Enzyme Expression.” Enzyme and Microbial Technology, 141: 109671.

8.Taicheng Zhu, Tongxin Zhao, Olufemi Emmanuel Bankefa, Yin Li*. “Engineering Unnatural Methylotrophic Cell Factories for Methanol-Based Biomanufacturing: Challenges and Opportunities.” Biotechnology Advances, 39: 107467.

9.Taicheng Zhu, Hongbing Sun, Meiyu Wang, Yin Li*. “Pichia pastoris as a Versatile Cell Factory for the Production of Industrial Enzymes and Chemicals: Current Status and Future Perspectives.” Biotechnology Journal, 14(6): 1800694.

10.Bankefa, Olufemi Emmanuel, Meiyu Wang, Taicheng Zhu*, Yin Li*. “Enhancing the Secretion Pathway Maximizes the Effects of Mixed Feeding Strategy for Glucose Oxidase Production in the Methylotrophic Yeast Pichia pastoris.” Bioresources and Bioprocessing, 5(1): 25.

11.Bankefa, Olufemi Emmanuel, Meiyu Wang, Taicheng Zhu*, Yin Li*. “Hac1p Homologues from Higher Eukaryotes Can Improve the Secretion of Heterologous Proteins in the Yeast Pichia pastoris.” Biotechnology Letters, 40(7): 1149–56.

12.Li, Hao#, Taicheng Zhu#,*, Liangtian Miao, Dan Zhang, Yongxian Li*, Qi Li, Yin Li*. “Discovery of Novel Highly Active and Stable Aspartate Dehydrogenases.” Scientific Reports, 7(1): 7881.

13.Sun, Hongbing, Olufemi Emmanuel Bankefa, Ijeoma Onyinyechi Ijeoma, Liangtian Miao, Taicheng Zhu*, Yin Li*. “Systematic Assessment of Pichia pastoris System for Optimized β -Galactosidase Production.” Synthetic and Systems Biotechnology, 2(2): 113–20.

14.Li, Pengfei, Hongbing Sun, Zao Chen, Yin Li, Taicheng Zhu*. “Construction of Efficient Xylose Utilizing Pichia pastoris for Industrial Enzyme Production.” Microbial Cell Factories, 14(1): 22.

15.Taicheng Zhu, Hongbing Sun, Pengfei Li, Yanfen Xue, Yin Li*, Yanhe Ma*. “Constitutive Expression of Alkaline β-Mannanase in Recombinant Pichia pastoris.” Process Biochemistry, 49(12): 2025–29.

1.国家自然科学基金，“毕赤酵母的甲醇-木糖协同代谢机制研究“，任务编号：32270058，执行期：2023.1-2026.12

2.国家重点研发计划绿色生物制造专项“一碳化合物生物转化制备燃料与化学品技术”项目，任务编号：2021YFC2103503，执行期：2021.12-2024.11

3.国家合成生物技术创新中心，天津市合成生物技术创新能力提升行动，毕赤酵母高分泌表达细胞底盘的深度改造，任务编号：TSBICIP-KJGG-006-19，执行期：2020.7.1—2022.9.30

4.国家自然科学基金，“氧化还原态对甲醇代谢调控机制研究及高效甲醇细胞工厂改造”，任务编号：31970039，执行期：2020.1-2024.12

5.国家重点研发计划合成生物学专项“微生物化学品工厂的设计重构”子课题"C1 利用的高效生物途径设计"，任务编号：2018YFA0901402，执行期：2019.1-2024.12

6.院重点部署项目子课题，“酵母光能转化模块的构建与优化”，任务编号：ZDRW-ZS-2016-3F，执行期：2017.1-2018.12

7.院重点部署项目“二氧化碳的人工生物转化”子课题，“创建新光能转化系统”，任务编号：ZDRW-ZS-2016-3，执行期2016.1-2018.12

8.院对外合作重点项目 “一带一路”沿线国家生物科技促进与产业合作计划，“谷氨酰胺转氨酶高产菌株和工艺的开发”，任务编号：155112KYSB20160010；执行期：2016.1-2016.12