病毒的入侵是病毒感染的首要步骤，影响病毒宿主范围、跨种传播、组织嗜性等。病毒与受体的结合是病毒入侵的关键步骤，也是疫苗设计和抗病毒药物开发的重要靶点。因此病毒受体的发现和病毒-受体互作机制的解析，不仅是认识病毒感染的重要环节，更是药物和疫苗研发的基础。而病毒-宿主互作关键位点的突变，将引起病毒感染性质和免疫原性的变化。因此，研究病毒与受体相互作用机制及免疫影响，对于病毒药物疫苗的研发至关重要。

　　研究团队一直致力于重要病毒入侵机制及抗病毒免疫的研究。通过整合病毒学、免疫学、结构生物学等研究方法，研究以肠道病毒和新冠病毒为代表的人类致病病毒。围绕着病毒的入侵步骤，发现病毒入侵关键受体，阐明病毒与受体结合及入侵机制，剖析病毒入侵中的关键氨基酸突变及其对感染和免疫的影响，并进一步进行病毒免疫逃逸和疫苗免疫策略优化研究。不仅为科学防控提供理论基础，也为药物疫苗研发和应用提供了新思路。

代表性论文成果

1.Chen, Xiangpeng#; Qu, Xiao#; Liu, Congcong#; Zhang, Yong; Zhang, Guigen; Han, Pu; Duan, Yali; Li, Qi; Wang, Liang; Ruan, Wenjing; Wang, Peiyi; Wei, Wensheng; Gao, George F.*; Zhao, Xin*; Xie, Zhengde*; Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18, mBio, 2022, e01166-22

2.    Zhao, Xin#; Zhang, Rong#; Qiao, Shitong#; Wang, Xiao; Zhang, Weibing; Ruan, Wenjing; Dai, Lianpan; Han, Pengcheng; Gao, George F.; Omicron SARS-CoV-2 Neutralization from Inactivated and ZF2001 Vaccines, New England Journal of Medicine, 2022, 387(3): 277-280

3.    Li, Linjie#; Liao, Hanyi#; Meng, Yumin#; Li, Weiwei#; Han, Pengcheng#; Liu, Kefang; Wang, Qing; Li, Dedong; Zhang, Yanfang; Wang, Liang; Fan, Zheng; Zhang, Yuqin; Wang, Qiyue; Zhao, Xin*; Sun, Yeping*; Huang, Niu*; Qi, Jianxun; Gao, George Fu*; Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1, Cell, 2022, 185: 1-9

4.    Zhao, Xin#; Li, Dedong#; Ruan, Wenjing#; Chen, Zhihai#; Zhang, Rong; Zheng, Anqi; Qiao, Shit ng; Zheng, Xinlei; Zhao, Yingze; Dai, Lianpan; Han, Pengcheng; Gao, George F.; Effects of a Prolonged Booster Interval on Neutralization of Omicron Variant, New England Journal of Medicine, 202 2, 386(9)

5.    Zhang, Rong; Li, Dedong; Xu, Kun; Yang, Chenxi; Luo, Tingrong; Zhao, Xin*; Gao, George F ; A protein subunit vaccine booster following two doses of inactivated SARS-CoV-2 vaccine provides high neutralisation of SARS-CoV-2 and its variants in mice, The Lancet microbe, 2022, Mar. 3(3): e165-e166

6.    Han, Pengcheng#; Su, Chao#; Zhang, Yanfang#; Bai, Chongzhi#; Zheng, Anqi; Qiao, Chengpeng; Wa ng, Qing; Niu, Sheng; Chen, Qian; Zhang, Yuqin; Li, Weiwei; Liao, Hanyi; Li, Jing; Zhang, Zengyua n; Cho, Heecheol; Yang, Mengsu; Rong, Xiaoyu; Hu, Yu; Huang, Niu; Yan, Jinghua; Wang, Qihui; Zhao, Xin*; Gao, George F.*; Qi, Jianxun*; Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants, Nature Communications, 2021, 12(1): 6103

7.    Zhao, Xin#; Zheng, Anqi#; Li, Dedong#; Zhang, Rong; Sun, Huan; Wang, Qihui; Gao, George F; H an, Pengcheng*; Dai, Lianpan*; Neutralisation of ZF2001-elicited antisera to SARS-CoV-2 variants, The Lancet microbe, 2021, Oct 2(10): e494-e494

8.   牛胜#;刘闯#;刘聪聪;刘升;宋洋;张勇;田文霞;赵欣#;王培毅#;高福#;埃可病毒11型利用双受体CD55和FcRn侵染细胞的分子结构基础,科学通报, 2020, 65(01): 67-79

9.    Zhao, Xin#; Zhang, Guigen#; Liu, Sheng#; Chen, Xiangpeng#; Peng, Ruchao; Dai, Lianpan; Qu, Xiao; Li, Shihua; Song, Hao; Gao, Zhengrong; Yuan, Pengfei; Liu, Zhiheng; Li, Changyao; Shang, Zifa ng; Li, Yan; Zhang, Meifan; Qi, Jianxun; Wang, Han; Du, Ning; Wu, Yan; Bi, Yuhai; Gao, Shan; Shi, Yi; Yan, Jinghua; Zhang, Yong; Xie, Zhengde*; Wei, Wensheng*; Gao, George F.*; Human Neonatal Fc Re ceptor Is the Cellular Uncoating Receptor for Enterovirus B, Cell, 2019, 177(6): 1553-1565 

代表性图片

 B族肠道病毒受体及入侵机制（Cell, 2019）

参编专著