肿瘤免疫与微生物组
2016-2019 清华大学, 博士后
2019-2024 美国芝加哥大学 博士后、研究助理教授
2024-至今 中国科学院微生物研究所,研究员
1) Si W, Zhao X, et al., Zhang J*, Liu HW*, Wang L* (Corresponding author). Lactobacillus rhamnosus GG induces STING-dependent IL-10 in intestinal monocytes and alleviates inflammatory colitis in mice. Journal of Clinical Investigation. 2025 Feb 3;135(3):e174910.
2) Wang L* (First and co-corresponding author), Weichselbaum RR, He C*. N6-methyladenosine reader YTHDF2 in cell state transition and antitumor immunity. RNA. 2025;31(3):395-401. (Invited review)
3) Wen C#, Wang L# (co-first author), et al., He C*, Liang H*, Weichselbaum RR*. YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production. Journal of Clinical Investigation. 2024 Sep 26:e181612.
4) Wang L# (First author), Lynch C#, Pitroda SP#, et al., Weichselbaum RR*. Radiotherapy and immunology. Journal of Experimental Medicine. 2024;221(7):e20232101. (Invited Review)
5) Bugno J#, Wang L# (co-first author), et al., Fu YX*, Liang H*, Weichselbaum RR*. Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance. Clinical Cancer Research. 2024;CCR-23-3616.
6) Wang L#* (First and co-corresponding author), Si W#, Yu X#, Piffko A, Dou X, Ding X, Bugno J, Yang K, Wen C, Zhang L, Chen D, Huang X, Wang J, Arina A, Pitroda S, Chmura S, He C, Liang H*, Weichselbaum RR*. Epitranscriptional regulation of TGF-β pseudoreceptor BAMBI by m6A/YTHDF2 drives extrinsic radioresistance. The Journal of Clinical Investigation. 2023;133(24):e172919.
7) Wang L* (First and co-corresponding author), Katipally RR, Liang H, Yang K, Pitroda S, He C, Weichselbaum RR*. RNA m6A methylation and MDSCs: roles and therapeutic implications for radiotherapy. Med.2023;4(12):863-874..
8) Wang L# (First author), Dou X#, Chen S#, Yu X, Huang X, Zhang L, Chen Y, Wang J, Yang K, Bugno J, Pitroda S, Ding X, Piffko A, Si W, Chen X, Jiang H, Zhou B, Chmura S, Luo C*, Liang H*, He C*, Weichselbaum RR*. YTHDF2 inhibition potentiates radiotherapy anti-tumor efficacy. Cancer Cell. 2023 May S1535-6108(23)00163-0.Spotlighted in Deng, Cell Chemical Biology. 2023,30 (7).
9) Si W, Liang H, Bugno J, Xu Q, Ding X, Yang K, Fu Y, Weichselbaum RR*, Zhao X*, Wang L* (Corresponding author). Lactobacillus rhamnosus GG induces cGAS/STING- dependent type I interferon and improves response to immune checkpoint blockade. Gut. 2022 Mar;71(3):521-533.
10) He L#, Wang L# (co-first author), Wang Z#, Li T, Chen H, Hu Z, Dimitrov D, Du J*, Liao X*. An Immune Modulating Antibody-Drug Conjugate (IM-ADC) For Cancer Immunotherapy. Journal of Medicinal Chemistry. 2021 Nov 11;64(21):15716-15726.
11) Ding X#, Wang L# (co-first author), Zhang X, Xu J, Li P, Liang H, Zhang X, Xie L, Zhou Z, Yang J, Weichselbaum RR*, Yu J*, Hu M*. The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia. Journal of Hematology & Oncology. 2021 Jun 12;14(1):92.
12) Wang L# (First author), Gao Y#, Zhang G#, Li D#, Wang Z, Zhang J, Hermida CL, He L, Wang Z, Si J, Geng S, Ai R, Ning F, Cheng C, Deng H, Dimitrov SD, Sun Y, Huang Y, Wang D, Hu X*, Wei Z*, Wang W*, Liao X*. Enhancing KDM5A and TLR activity improves the response to immune checkpoint blockade. Science Translational Medicine. 2020 Sep 9;12(560):eaax2282.