1.真菌异染色质组装、表观遗传修饰及其跨代遗传的分子调控机制
2.植物-真菌互作的表观遗传学调控机制
2014.10-2019.09 美国哥伦比亚大学, 博士后
2019.10-2021.10 美国哥伦比亚大学, 副研究科学家
2021.10-2022.11 中国科学院微生物研究所, 项目研究员
2022.11- 中国科学院微生物研究所, 研究员
1.Toda T#, Fang Y#, Shan CM#*, Xu H, Kim JK, Tang L, Jovanovic M, Tong L, Qiao F, Zhang ZG, Jia S* (2024) Mrc1 regulates parental histone segregation and heterochromatin inheritance. Molecular Cell; 84(17):3223-3236.e4. doi: 10.1016/j.molcel.2024.07.002. (Cover story)
2. Fang Y, Xu H, Shan CM, Toda T, Qiao F, Zhang Z, Jia S* (2024) Coordination of histone chaperones for parental histone segregation and epigenetic inheritance. Genes and Development; 38: 189-204. (Cover story)
3. Yang J#, Liu M#, Jiao Y, Guo HS, Shan CM*, Wang H* (2024) An Efficient Homologous Recombination-Based In Situ Protein-Labeling Method in Verticillium dahliae. Biology 13 (2), 81.
4. Giacomini G, Piquet S, Chevallier O, Dabin J, Bai S, … Shan CM, Reid R, Toda T, … Rondinelli B*, Polo S* (2024) Aberrant DNA repair reveals a vulnerability in histone H3.3-mutant brain tumors. Nucleic Acids Research; 52(5): 2372-2388.
5. Miao Z#, Wang H#, Tu X#, Huang Z, Huang S, Zhang X, Wang F, Huang Z, Li H, Jiao Y, Gao S, Zhou Z, Shan CM*, Li J*, Yue JX* (2023) GetPrimers: A generalized PCR-based genetic targeting primer designer enabling easy and standardized targeted gene modification across multiple systems. Yeast; https://doi.org/10.1002/yea.3916
6. Shan CM, Fang Y, Jia S* (2023) Leaving histone unturned for epigenetic inheritance (Invited review). The FEBS Journal; doi:10.1111/febs.16260
7. Du W#, Shi G#, Shan CM#, Li Z#, Zhu B*, Jia S*, Li Q*, Zhang ZG* (2022) Mechanisms of chromatin-based epigenetic inheritance (Invited Review). Science China Life Sciences, 65(11):2162-2190.
2021年及以前:
1.Shan CM, Kim JK, Wang J, Bao K, Sun Y, Chen H, Yue JX, Stripe A, Schalch T, Liti G, Nagy PL, Tong L, Qiao F, Jia S* (2021) The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin. Cell Reports; 35(7):109137.
2. Shan CM, Bao K, Diedrich J, Chen X, Chao Lu, Yates JR, Jia S* (2020) The INO80 complex regulates epigenetic inheritance of heterochromatin. Cell Reports; 33(13):108561.
3. Bao KH#, Shan CM#, Moresco JJ, Yates JR, Jia S*. Antisilencing factor Epe1 recruits SAGA to promote transcription within heterochromatin (2018) Genes and Development; 33(1-2): 116–126.
4. Zhang Y#, Shan CM#, Wang J#, Bao K, Tong L*, Jia S*. (2017) Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation. Scientific Reports 7, 43906; doi: 10.1038/srep43906.
5. Shan CM#, Wang J#, Xu K#, Chen H, Yue JX, Andrews S, Moresco JJ, Yates JR, Nagy PL, Tong L*, Jia S*. (2016) A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading. eLife; doi: 10.7554/eLife.17903
6. Shan CM, Shangguan XX, Zhao B, Zhang XF, Chao L, Yang CQ, Wang LJ, Zhu HY, Zen YD, Guo WZ, Zhou BL, Hu GJ, Guan XY, Chen ZJ, Wendel JF, Zhang TZ*, Chen XY.* (2014) Control of cotton fiber elongation by a homeodomain transcription factor, GhHOX3. Nature Communications; 5:5519; doi: 10.1038/ncomms6519.
7. Bao K, Shan CM, Chen X, et al. (2022) The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly. PLoS Genetics 18(2): e1010049
8. Cao JF#, Zhao B#, Huang CC, Chen ZW, Zhao T, Liu HR, Hu GJ, Shangguan XX, Shan CM, Wang LJ, Zhang TZ, Wendel JF, Guan XY, Chen XY* (2020) The miR319-targeted GhTCP4 promotes the transition from cell elongation to wall thickening in cotton fiber. Molecular Plant 13 (7), 1063-1077
9. Liu X#, Zhao B#, Zheng HJ#, Hu Y#, Lu G, … Shan CM, Jiang JP, Zhu YQ, ... Zhang GY*, Wang SY, Zhang TZ*, Zhao GP, Chen XY* (2015) Gossypium barbadense genome sequence provides insight into the evolution of extra-long staple fiber and specialized metabolites. Scientific Reports 5:14139;
10. Yu ZX, Wang LJ, Zhao B, Shan CM, Zhang YH, Chen DF, and Chen XY*. (2015) Progressive regulation of sesquiterpene biosynthesis in Arabidopsis inflorescence by the miR156-Targeted SPL transcription factors. Molecular Plant 8 (1), 98-110
11. Yu N#, Cai WJ#, Wang SC, Shan CM, Wang LJ, Chen XY* (2010) Temporal control of trichome distribution by microRNA156-targeted SPL Genes in Arabidopsis thaliana. The Plant Cell 22: 2322–2335.
12. Guan XY, Li QJ, Shan CM, Wang S, Mao YB, Wang LJ, Chen XY* (2008) The HD-Zip IV gene GaHOX1 from cotton fiber is a functional homologue of the Arabidopsis GLABRA2 gene. Physiologia Plantarum. 134: 174–182.