本研究组面向新药研发的国家重大需求，聚焦微生物来源的聚酮类和非核糖体肽类天然产物，融合生物学、化学、信息学与人工智能等多学科手段，系统开展基础与应用研究。主要包括：基于基因组信息的天然产物精准挖掘；复杂结构天然产物的生物合成机制解析及酶催化元件的发现与利用；以及基于合成生物学的活性分子创新与高效获取。

1.Wang H#, Wang L#, Li D#, Fan K, Yang Y, Cao H, Sun J, Ren J, Liu Y, Xiang L, Li W, Pan M, Hu H, Chen Y, Xu Z, Huang Y, Wang W,  Pan G*. Uncovering the molecular landscape of tetracycline family natural products through bacterial genome mining. J Am Chem Soc, 2025, 147(18): 15100-15114.

2. Shen S#, Chi C#, Fan K, Zhang Q, Xu Y, Gao J, Hu H, Wang L, Yang D, Ma M*, Pan G*. Functional conservation and divergence of AlpJ-family oxygenases catalyzing C-C bond cleavage in atypical angucycline biosynthesis. ACS Chem Biol, 2025, 20(7):1481–1491.

3. Yang T, Chen Y, Luo X, Keasling JD, Fan K*, Pan G*. A simple and effective strategy for the development of robust promoter-centric gene expression tools. ACS Synth Biol, 2024, 13(9): 2780-2790.

4. Wang J, Wang W, Chen Y, Liu Z, Ji X, Pan G, Li Z*, Fan K*.  Development of a xylose-inducible and glucose-insensitive expression system for Parageobacillus thermoglucosidasius. Appl Microb Biotechnol, 2024, 108(1): 493.

5. Gao J#, Li L#, Shen S, Ai G, Wang B, Guo F, Yang T, Han H, Xu Z, Pan G*, Fan K*. Cofactor-independent C–C bond cleavage reactions catalyzed by the AlpJ family of oxygenases in atypical angucycline biosynthesis. Beilstein J Org Chem, 2024, 20: 1198-1206.

6. Wang H#, Wang L#, Fan K, Pan G*. Tetracycline natural products: discovery, biosynthesis and engineering. Chin J Nat Med, 2022, 20(10): 773-794.

7. Wang J#, Li Z#, Wang W, Pang S, Yao Y, Yuan F, Wang H, Xu Z, Pan G, Liu Z, Chen Y*, Fan K*. Dynamic control strategy to produce riboflavin with lignocellulose hydrolysate in the thermophile Geobacillus thermoglucosidasius. ACS Synth Biol, 2022, 11(6): 2163-2174.

8. Zhang Q#, Ren J#, Wang W, Zhai J, Yang J, Liu N, Huang Y, Chen Y, Pan G*, Fan K*. A versatile transcription-translation in one approach for activation of cryptic biosynthetic gene clusters. ACS Chem Biol, 2020, 15(9): 2551-2557.

9. Xu Z#, Pan G#, Zhou H, Shen B*. Discovery and characterization of 1-aminocyclopropane-1-carboxylic acid synthase of bacterial origin. J Am Chem Soc. 2018, 140(49):16957-16961.

10. Pan G#, Xu Z#, Guo Z, Hindra, Ma M, Yang D, Zhou H, Gansemans Y, Zhu X, Huang Y, Zhao LX, Jiang Y, Cheng J, Van Nieuwerburgh F, Suh JW, Duan Y, Shen B*. Discovery of the leinamycin family of natural products by mining actinobacterial genomes. Proc Natl Acad Sci U S A. 2017, 114(52):E11131-E11140.

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2、科技部国家重点研发计划，高值化合物生物合成体系的智能组装及高效运行，2020/11-2025/10

3、国家自然科学基金面上项目，细菌中非核糖体脂肽类天然产物生物合成潜能系统分析及新产物发掘
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