放线菌系统进化与资源利用
1994.07-1996.08 四川大学,助教
1999.08-2001.12 中国科学院微生物研究所,助理研究员
2001.12-2007.05 中国科学院微生物研究所,副研究员
2007.05-2011.12 中国科学院微生物研究所,研究员
2011.12-2023.08 中国科学院微生物研究所,微生物资源前期开发国家重点实验室,副主任、研究员
2023.08-至今 中国科学院微生物研究所,微生物多样性与资源创新利用全国重点实验室,研究员
主要从事放线菌多样性与进化、生态学及资源发掘利用研究,旨在应用和发展微生物系统进化与资源评估利用的理论和方法,解析特殊生境放线菌的多样性、生态适应性和功能,揭示其物种和功能演化的途径和机制,促进放线菌等微生物资源开发和生态应用。
1. Huang J, Zheng X, Yu T, Ali M, Wiese J, Hu S, Huang L, Huang Y*. 2025. Diverse lifestyles and adaptive evolution of uncultured UBA5794 actinobacteria, a sister order of “Candidatus actinomarinales”. Environmental Microbiome, 20: 39.
2. Wang K, Liu N, Liu M*, Zhao P, Zhong N, Challis GL, Huang Y*. 2024. Discovery and biosynthesis of streptolateritic acids A–D: acyclic pentacarboxylic acids from Streptomyces sp. FXJ1.172 with promising activity against potato common scab. J Agr Food Chem, 72 (26): 14760-14768.
3. Du X, Liu N, Yan B, Li Y, Liu M*, Huang Y*. 2024. Proximity-based defensive mutualism between Streptomyces and Mesorhizobium by sharing and sequestering iron. ISME J, 18(1): wrad041.
4. Bai B, Zhang L*, Dong H, Huang Y*. 2023. Coupled Fe(III) reduction and phenanthrene degradation by marine-derived Kocuria oceani FXJ8.057 under aerobic condition. J Hazard Mater, 459: 132237.
5. Liu M#, Wang K#, Wei J#, Liu N, Niu G, Tan H, Huang Y*. 2023. Comparative and functional analyses reveal conserved and variable regulatory systems that control lasalocid biosynthesis in different Streptomyces species. Microbiol Spectr, 11(2): e0385222
6. Wang J, Li Y, Pinto-Tomás AA, Cheng K, Huang Y*. 2022. Habitat adaptation drives speciation of a Streptomyces species with distinct habitats and disparate geographic origins. mBio, 13(1): e02781-21.
7. Li Y, Huang Y*. 2022. Distribution and evolutionary history of sialic acid catabolism in the phylum Actinobacteria. Microbiol Spectr, 10(1): e02380-21.
8. Yan B, Liu N, Liu M, Du X, Shang F, Huang Y*. 2021. Soil actinobacteria tend to have neutral interactions with other co-occurring microorganisms, especially under oligotrophic conditions. Environ Microbiol, 23(8): 4126–4140.
9. Zhang L, Zeng Q, Liu X, Chen P, Guo X, Ma LZ, Dong H*, Huang Y*. 2019. Iron reduction by diverse actinobacteria under oxic and pH-neutral conditions and the formation of secondary minerals. Chem Geol, 525: 390-399.
10. Li Y, Pinto-Tomás AA, Rong X, Cheng K, Liu M, Huang Y*. 2019. Population genomics insights into adaptive evolution and ecological differentiation in streptomycetes. Appl Environ Microbiol, 85: e02555-18.
11. Zhang L, Dong H*, Liu Y, Bian L, Wang X, Zhou Z, Huang Y*. 2018. Bioleaching of rare earth elements from bastnaesite-bearing rock by actinobacteria. Chem Geol, 483: 544-557.
12. Huang B, Li DG, Huang Y*, Liu CT*. 2018. Effects of spaceflight and simulated microgravity on microbial growth and secondary metabolism. Military Med Res, 5(1): 18.
1. 国家载人航天工程项目,空间环境对典型放线菌表型和遗传的影响规律及其分子机制研究,KJZ-YY-WSM0501,2025/01-2027/12
2. 国家载人航天工程项目,空间微重力对微生物的效应机制研究,YYWT-0801-EXP-08,2020/07-2026/12
3. 国家自然科学基金面上项目,青藏高原无人区土壤放线菌代表类群的系统发育和适应性进化,32470005,2025/01-2028/12
4. 国家自然科学基金面上项目,近交远伐:链霉菌与根瘤菌之间独特的互作策略及其机制,32270122,2023/01-2026/12
5. 国家自然科学基金面上项目,生态适应对链霉菌物种形成的作用和机制,32070001,2021/01-2024/12
6. 中国科学院国际合作重点项目,利用放线菌生物多样性发现应对细菌耐药性的新抗生素,153211KYSB20170014,2018/01-2020/12
7. 国家自然科学基金重大研究计划培育项目,印度洋中脊热液区沉积物放线菌在铁还原耦合有机质降解中的作用,91751118,2018/01-2020/12
8. 国家自然科学基金面上项目,红壤中的放线菌与其他微生物的相互作用研究,31670502,2017/01-2020/12
9. 企业技术开发项目,红色诺卡氏菌细胞壁骨架(Nr-CWS)生产菌种复壮及发酵条件优化关键技术,2022/11-2024/11
10. 企业技术开发项目,红色诺卡氏菌细胞壁骨架(Nr-CWS)生产菌种空间育种使能关键技术,2025/08-2027/12