主要研究方向为基于人工智能的微生物催化元件挖掘、机理解析、酶工程改造，并面向微生物碳、氮元素代谢途径中的重要酶，在干湿结合的研究体系基础上，深入理解微生物酶进化过程中暗藏的复杂规律，拓展其非天然催化功能，延伸微生物的物质转化能力。

1. Jinyuan Sun, Tong Zhu, Yinglu Cui*, Bian Wu*. Structure-based self-supervised learning enables ultrafast protein stability prediction upon mutation. The Innovation 2025, 6(1):100750.

2. Yinglu Cui#*, Yanchun Chen#, Jinyuan Sun#, Tong Zhu#, Hua Pang, Chunli Li, Wen-Chao Geng, Bian Wu*. Computational redesign of a hydrolase for nearly complete PET depolymerization at industrially relevant high-solids loading, Nature Communications, 2024, 15: 1417.

3. Yue Tang#, Xiaoying Tian#, Min Wang#, Yinglu Cui#, Yang She#, Zhaoxiang Shi, Jiaqi Liu,Huijin Mao, Lilu Liu, Chao Li, Yuwei Zhang, Pengwei Li, Yue Ma, Jinyuan Sun, Qing Du, Jie Li, Jun Wang, De-feng Li, Bian Wu*, Feng Shao*, Yihua Chen*. The β-d-manno-heptoses are immune agonists across kingdoms. Science, 2024, 385: 678-684.

4. Yinglu Cui, Jinyuan Sun, Bian Wu*. Computational enzyme redesign: large jumps in function, Trends in Chemistry, 2022, 4(5): 409-419.

5. Yinglu Cui#, Yinghui Wang#, Wenya Tian#, Yifan Bu, Tao Li, Xuexian Cui, Tong Zhu, Ruifeng Li, Bian Wu*. Development of a versatile and efficient C-N lyase platform for asymmetric hydroamination via computational enzyme redesign, Nature Catalysis, 2021, 4: 364-373.

6. Yinglu Cui#, Yanchun Chen#, Xinyue Liu, Saijun Dong, Yu’e Tian, Yuxin Qiao, Ruchira Mitra, Jing Han, Chunli Li, Xu Han, Weidong Liu, Quan Chen, Wangqing Wei, Xin Wang, Wenbin Du, Shuangyan Tang, Hua Xiang, Haiyan Liu, Yong Liang, Kendall N. Houk, Bian Wu. Computational redesign of a PETase for plastic biodegradation under ambient condition by the GRAPE strategy, ACS Catalysis, 2021, 11(3): 1340-1350.