团组负责人
刘双江
刘双江  、研究员 、博士生导师
研究方向:

人体与环境微生物组、难降解及新型污染物的微生物代谢、调控和趋化机理的研究及应用

电话/传真:+86(10)64807423
电子邮件:liusj@im.ac.cn
通讯地址:北京市朝阳区北辰西路1号院3号

工作经历

2025-至今, 中国科学院微生物研究所, 微生物多样性与资源创新利用全国重点实验室, 研究员   

2001- 2024, 中国科学院微生物研究所, 微生物资源前期开发国家重点实验室, 研究员

1998/08-2001/02, 德国Muenster大学, 微生物技术研究所, 访问学者                    

1997/08-1998/07, 美国James Madison大学,博士后

1996/08-1997/07, 日本筑波市国立生命工学研究所,博士后

1995/06 -1996/07, 德国Muenster大学,博士后

1991/03-1995/05, 中国科学院微生物研究所, 微生物生理生态研究室, 助理/副研究员

获奖及荣誉

2007年获得国家杰出青年基金奖    

2010年获得全国优秀科技工作者荣誉称号                     

2005年获政府特殊津贴

社会兼职

iMeta主编; 《微生物学报》执行主编;《生物工程学报》副主编、mLife编委、Microorganisms, Archives of Microbiology, Microbes and Environments, Fundamental Research等杂志编辑。

代表成果

[1] Yu Y., Wang Y. J., Zhang J., Li S. C., Wang Y. L., You X., Chen X., Du M. X., Xie L. S., Liu S. J.*, The gut commensal attenuates indole-AhR signaling and restores ASD-like behaviors with BTBR mice, Frontiers in microbiology, 16 (2025).
[2] Wu T., Guo S. Z., Zhang Y., Zhao X. Z., Ran C. G., Liu F. L., Wang R. H., Li D. F., Zhu H. Z., Jiang C. Y., Shen X. H., Liu S. J.*, The engineering of TBBPA-degrading synthetic microbiomes with integrated strategies, Npj Biofilms Microbi, 11 (2025).
[3] Huang Y., Li X. T., Jiang Z., Liang Z. L., Liu W., Liu Z. H., Li L. Z., Yang Z. N., Zhang G. Q., Yin H. Q., Liang J. L., Zhou N., Liu S. J.*, Jiang C. Y., Mineral types dominate microbiomes and biogeochemical cycling in acid mine drainage, Water Res., 278 (2025).
[4] Abdugheni R., Liu S. J.*, Potential pitfalls in claiming novel taxa, Imeta, 4 (2025).
[5] Wei Z. Y., Feng M., Zhang D. X., Jiang C. Y., Deng Y., Wang Z. J., Feng K., Song Y., Zhou N., Wang Y. L., Liu S. J.*, Deep insights into the assembly mechanisms, co-occurrence patterns, and functional roles of microbial community in wastewater treatment plants, Environ. Res., 263 (2024).
[6] Sun X. W., Huang H. J., Wang X. M., Wei R. Q., Niu H. Y., Chen H. Y., Luo M., Abdugheni R., Wang Y. L., Liu F. L., Jiang H., Liu C., Liu S. J.*, Christensenella strain resources, genomic/metabolomic profiling, and association with host at species level, Gut Microbes, 16 (2024).
[7] Qin Y. L., Liang Z. L., Ai G. M., Liu W. F., Tao Y., Jiang C. Y., Liu S. J.*, Li D. F., Heterotrophic nitrification by Alcaligenes faecalis links organic and inorganic nitrogen metabolism, ISME J., 18 (2024).
[8] Liu Z. S., Wang K. H., Han Q., Jiang C. Y., Liu S. J.*, Li D. F., sp. SJ10-10 encodes a not-yet-reported chromate reductase and the classical Rieske dioxygenases to simultaneously degrade PAH and reduce chromate, J. Hazard. Mater., 475 (2024).
[9] Liu C., Du M. X., Xie L. S., Wang W. Z., Chen B. S., Yun C. Y., Sun X. W., Luo X., Jiang Y., Wang K., Jiang M. Z., Qiao S. S., Sun M., Cui B. J., Huang H. J., Qu S. P., Li C. K., Wu D. L., Wang L. S., Jiang C. T., Liu H. W., Liu S. J.*, Gut commensal modulates host metabolism via acylated secondary bile acids, Nat Microbiol, 9 (2024).
[10] Huang H. J., Liu C., Sun X. W., Wei R. Q., Liu L. W., Chen H. Y., Abdugheni R., Wang C. Y., Wang X. M., Jiang H., Niu H. Y., Feng L. J., He J. H., Jiang Y., Zhao Y., Wang Y. L., Shu Q., Bi M. X., Zhang L., Liu B., Liu S. J.*, The rheumatoid arthritis gut microbial biobank reveals core microbial species that associate and effect on host inflammation and autoimmune responses, Imeta, 3 (2024).
[11] Wu T., Guo S. Z., Zhu H. Z., Yan L., Liu Z. P., Li D. F., Jiang C. Y., Corvini P. F. X., Shen X. H., Liu S. J.*, The sulfonamide-resistance dihydropteroate synthase gene is crucial for efficient biodegradation of sulfamethoxazole by species, Appl. Microbiol. Biotechnol., 107, 5813-5827 (2023).
[12] Li X. T., Huang Z. S., Huang Y., Jiang Z., Liang Z. L., Yin H. Q., Zhang G. J., Jia Y., Deng Y., Liu S. J.*, Jiang C. Y., Responses of microbial community to geochemical parameters on vertical depth in bioheap system of low-grade copper sulfide, Sci. Total Environ., 869 (2023).
[13] Guo L., Wang Y. H., Cui R., Huang Z., Hong Y., Qian J. W., Ni B., Xu A. M., Jiang C. Y., Zhulin I. B., Liu S. J.*, Li D. F., Attractant and repellent induce opposing changes in the four-helix bundle ligand-binding domain of a bacterial chemoreceptor, PLoS Biol., 21 (2023).
[14] Chen H. H., Wang Y. X., Li D. F., Liu C., Bi S. Y., Jiang C. Y., Liu S. J.*, Chemoreceptors from the commensal gut bind to mucin and trigger chemotaxis, Environ. Microbiol., 25 (2023) 1329-1343.
[15] Yang Z. N., Liu Z. S., Wang K. H., Liang Z. L., Abdugheni R., Huang Y., Wang R. H., Ma H. L., Wang X. K., Yang M. L., Zhang B. G., Li D. F., Jiang C. Y., Corvini P. F. X., Liu S. J.*, Soil microbiomes divergently respond to heavy metals and polycyclic aromatic hydrocarbons in contaminated industrial sites, Environmental Science and Ecotechnology, 10 (2022).
[16] Qiao S. S., Liu C., Sun L., Wang T., Dai H. Q., Wang K., Bao L., Li H. T., Wang W. Z., Liu S. J.*, Liu H. W., Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism, Nat Metab, 4, 1271 (2022).
[17] Jiang M. Z., Zhu H. Z., Zhou N., Liu C., Jiang C. Y., Wang Y., Liu S. J.*, Droplet microfluidics-based high-throughput bacterial cultivation for validation of taxon pairs in microbial co-occurrence networks, Scientific reports, 12, 18145, (2022).
[18] Abdugheni R., Wang W. Z., Wang Y. J., Du M. X., Liu F. L., Zhou N., Jiang C. Y., Wang C. Y., Wu L. H., Ma J. C., Liu C., Liu S. J.*, Metabolite profiling of human-originated Lachnospiraceae at the strain level, Imeta, 1 (2022).
[19] Zhu H. Z., Zhang Z. F., Zhou N., Jiang C. Y., Wang B. J., Cai L., Wang H. M., Liu S. J.*, Bacteria and Metabolic Potential in Karst Caves Revealed by Intensive Bacterial Cultivation and Genome Assembly (vol 87, e02440-20, 2021), Appl. Environ. Microbiol., 87 (2021).
[20] Song Y., Jiang C. Y., Liang Z. L., Zhu H. Z., Jiang Y., Yin Y., Qin Y. L., Huang H. J., Wang B. J., Wei Z. Y., Cheng R. X., Liu Z. P., Liu Y., Jin T., Wang A. J., Liu S. J.*, Candidatus Kaistella beijingensis sp. nov., Isolated from a Municipal Wastewater Treatment Plant, Is Involved in Sludge Foaming, Appl. Environ. Microbiol., 87 (2021).
[21] Liu C., Du M. X., Abuduaini R., Yu H. Y., Li D. H., Wang Y. J., Zhou N., Jiang M. Z., Niu P. X., Han S. S., Chen H. H., Shi W. Y., Wu L., Xin Y. H., Ma J., Zhou Y., Jiang C. Y., Liu H. W., Liu S. J.*, Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank, Microbiome, 9, 119 (2021).
[22] Huang Y., Xu D. K., Huang L. Y., Lou Y. T., Muhadesi J. B., Qian H. C., Zhou E. Z., Wang B. J., Li X. T., Jiang Z., Liu S. J.*, Zhang D. W., Jiang C. Y., Responses of soil microbiome to steel corrosion, Npj Biofilms Microbi, 7 (2021).
[23] Wang Y. H., Chen H. H., Huang Z., Li X. J., Zhou N., Liu C., Jiang C. Y., Li D. F., Liu S. J.*, PapA, a peptidoglycan-associated protein, interacts with OmpC and maintains cell envelope integrity, Environ. Microbiol., (2020).
[24] Wang P., Li L. Z., Qin Y. L., Liang Z. L., Li X. T., Yin H. Q., Liu L. J., Liu S. J.*, Jiang C. Y., Comparative Genomic Analysis Reveals the Metabolism and Evolution of the Thermophilic Archaeal Genus Metallosphaera, Frontiers in microbiology, 11 (2020) 1192.
[25] Song Y., Jiang C. Y., Liang Z. L., Wang B. J., Jiang Y., Yin Y., Zhu H. Z., Qin Y. L., Cheng R. X., Liu Z. P., Liu Y., Jin T., Corvini P. F., Rabaey K., Wang A. J., Liu S. J.*, Casimicrobium huifangae gen. nov., sp. nov., a Ubiquitous "Most-Wanted" Core Bacterial Taxon from Municipal Wastewater Treatment Plants, Appl Environ Microbiol, 86 (2020).
[26] Liu C., Zhou N., Du M. X., Sun Y. T., Wang K., Wang Y. J., Li D. H., Yu H. Y., Song Y., Bai B. B., Xin Y., Wu L., Jiang C. Y., Feng J., Xiang H., Zhou Y., Ma J., Wang J., Liu H. W., Liu S. J.*, The Mouse Gut Microbial Biobank expands the coverage of cultured bacteria, Nat. Commun., 11 (2020) 79.

承担科研项目情况

1、国家自然科学基金重大项目, 土壤复合污染物的微生物转化及核心功能菌群构建,2020/01- 2024/12

2、科技部重点研发计划, 活性污泥人工多细胞体系构建与应用, 2020/01-2024/12                     

3、国家自然科学基金国际(地区)重大合作项目,有机污染物降解微生物组的功能解析和微生物菌群3D打印技术,2019/1-2022/12                       

4、中国科学院计划-战略性先导专项B课题,肠道微生物组分析技术与标准化系统的研究,2019/1-2023/12

5、中国科学院计划-院重点部署项目,人体与环境健康的微生物组共性技术研究,2017/10-2019/9

6、中国科学院对外合作重点项目,微生物资源深度挖掘和可持续利用国际合作网络, 2016/01-/2020/12   

7、国家自然科学基金杰出青年科学基金, 微生物学,2008/01-2011/12