近期代表性论文（* 通讯作者）

[2025]

Mitra R, Xu Y, Lin L, Guo J, Xu T, Zhou M, Guo F, Li H, Xiang H*, Han J*. Genetic identification of acetyl-CoA synthetases involved in acetate activation in Haloferax mediterranei. Applied and Environmental Microbiology. 2025;91(1):e0184324. Doi:10.1128/aem.01843-24.

Galeva A, Zhao D, Syutkin A, Topilina M, Shchyogolev S, Pavlova E, Selivanova O, Kireev I, Surin A, Burygin G, Liu J, Xiang H*, Pyatibratov M*. Tat-fimbriae (“tafi”): an unusual type of haloarchaeal surface structure depending on the twin-arginine translocation pathway. iScience. 2025; 28(2):111793. Doi: 10.1016/j.isci.2025.111793.

Wang X, Zhao D, Yu T, Zhu Y, Jiang M, Liu Y, Hu S, Luo Y, Xiang H*, Zheng Y*. Biological nitrogen fixation driven by methane anaerobic oxidation supports the complex biological communities in cold-seep habitat. Environmental Technology & Innovation. 2025; 37:103938. Doi: 10.1016/j.eti.2024.103938.

[2024]

Guo J, Gong L*, Yu H, Li M, An Q, Liu Z, Fan S, Yang C, Zhao D, Han J, Xiang H*. Engineered minimal type I CRISPR-Cas system for transcriptional activation and base editing in human cells. Nature Communications. 2024;15(1):7277. Doi:10.1038/s41467-024-51695-x.

Zhao D, Zhang S, Chen J, Zhao J, An P, Xiang H*. Members of the class Candidatus Ordosarchaeia imply an alternative evolutionary scenario from methanogens to haloarchaea. The ISME Journal. 2024;18(1). Doi:10.1093/ismejo/wrad033.

Yu T, Luo Y, Tan X, Zhao D, Bi X, Li C, Zheng Y, Xiang H*, Hu S*. Global marine cold seep metagenomes reveal diversity of taxonomy, metabolic function, and natural products. Genomics, Proteomics & Bioinformatics. 2024;22(2). Doi:10.1093/gpbjnl/qzad006.

Chen S, Dai Y, Ke J, Luo Y, Wang C, Hao Y, Zhang A, Han J, Xiang H*. Halocin H4 is activated through cleavage by halolysin HlyR4. Applied and Environmental Microbiology. 2024;90(4):e0228423. Doi:10.1128/aem.02284-23.

Chen J, Cui Y, Zhang S, Wu B, Han J*, Xiang H*. Unveiling the repressive mechanism of a PPS-like regulator (PspR) in polyhydroxyalkanoates biosynthesis network. Applied Microbiology and Biotechnology. 2024;108(1):265. Doi:10.1007/s00253-024-13100-x.

Cheng F, Wu A, Li Z, Xu J, Cao X, Yu H, Liu Z, Wang R, Han W, Xiang H*, Li M*. Catalytically active prokaryotic Argonautes employ phospholipase D family proteins to strengthen immunity against different genetic invaders. mLife. 2024;3(3):403-16. Doi:10.1002/mlf2.12138.

An P, Yang C, Li W, Zhao D*, Xiang H*. The isolation and characterization of a novel psychrotolerant cellulolytic bacterium, Microbacterium sp. QXD-8(T). Microorganisms. 2024;12(2):303. Doi:10.3390/microorganisms12020303.

Xu T, Mitra R, Tan D, Li Z, Zhou C, Chen T, Xie Z, Han J*. Utilization of gene manipulation system for advancing the biotechnological potential of halophiles: A review. Biotechnology Advances. 2024;70:108302. Doi: 10.1016/j.biotechadv.2023.108302.

[2023]

Liu C, Wang R, Li J, Cheng F, Shu X, Zhao H, Xue Q, Yu H, Wu A, Wang L, Hu S, Zhang Y, Yang J, Xiang H*, Li M*. Widespread RNA-based cas regulation monitors crRNA abundance and anti-CRISPR proteins. Cell Host & Microbe. 2023;31(9):1481-93 e6. Doi:10.1016/j.chom.2023.08.005.

Bera S, Chowdhury D , Han J* and Singh J*. Editorial: Applied and sustainable methods to manage environmental contaminants with natural and fortified microbial biosorbents. Frontiers in Microbiology. 2023;14: 1220337. Doi:10.3389/fmicb.2023.1220337.

Xu Y, Wang J, Xu T, Xiang Hua*, Han J*. [Research and application of haloarchaeal promoter]. Wei Sheng Wu Xue Bao 2023;63(2): 523–539. Doi: 10.13343/j.cnki.wsxb.20220426.

[2022]

Cheng F, Wu A, Liu C, Cao X, Wang R, Shu X, Wang L, Zhang Y, Xiang H*, Li M*. The toxin-antitoxin RNA guards of CRISPR-Cas evolved high specificity through repeat degeneration. Nucleic Acids Research. 2022;50(16):9442-52. Doi:10.1093/nar/gkac712.

Xu T, Chen J, Mitra R, Lin L, Xie Z, Chen GQ, Xiang H*, Han J*. Deficiency of exopolysaccharides and O-antigen makes Halomonas bluephagenesis self-flocculating and amenable to electrotransformation. Communications Biology. 2022;5(1):623. Doi:10.1038/s42003-022-03570-y.

Zhou H, Zhao D*, Zhang S, Xue Q, Zhang M, Yu H, Zhou J, Li M, Kumar S, Xiang H*. Metagenomic insights into the environmental adaptation and metabolism of Candidatus Haloplasmatales, one archaeal order thriving in saline lakes. Environmental Microbiology. 2022;24(5):2239-58. Doi:10.1111/1462-2920.15899.

Zhao D, Zhang S, Kumar S, Zhou H, Xue Q, Sun W, Zhou J, Xiang H*. Comparative genomic insights into the evolution of Halobacteria-associated "Candidatus Nanohaloarchaeota". mSystems. 2022;7(6):e0066922. Doi:10.1128/msystems.00669-22.

Mitra R, Xu T, Chen GQ, Xiang H*, Han J*. An updated overview on the regulatory circuits of polyhydroxyalkanoates synthesis. Microbial Biotechnology. 2022;15(5):1446-70. Doi:10.1111/1751-7915.13915.

Du K, Gong L*, Li M, Yu H, Xiang H*. Reprogramming the endogenous type I CRISPR-Cas system for simultaneous gene regulation and editing in Haloarcula hispanica. mLife. 2022;1(1):40-50. Doi:10.1002/mlf2.12010.

Yang H, Chen J, Mitra R, Xue Q, Xiang H*, Han J*. Replication origin deletion enhances poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthesis in haloarchaea. Microbiology Spectrum. 2022;10(6):e0214922. Doi:10.1128/spectrum.02149-22.

Yang M, Xue Q, Zuo Z, Zhou J, Zhang S, Li M, Zhou H, Zhang M, Kumar S, Li W, Chen G, Zhao D*, Xiang H*. Aliidiomarina halalkaliphila sp. nov., a haloalkaliphilic bacterium isolated from a soda lake in Inner Mongolia Autonomous Region, China. International Journal of Systematic and Evolutionary Microbiology. 2022;72(3). Doi:10.1099/ijsem.0.005263.

Zhou H, Yang M, Xue Q, Kumar S, Zhang S, Zhou J, Zhao D*, Xiang H*. Rhabdonatronobacter sediminivivens gen. nov., sp. nov. isolated from the sediment of Hutong Qagan Soda Lake. Archives of Microbiology. 2022;204(2):145. Doi:10.1007/s00203-022-02758-4.

[2021]

Li M, Gong L, Cheng F, Yu H, Zhao D, Wang R, Wang T, Zhang S, Zhou J, Shmakov SA, Koonin EV, Xiang H*. Toxin-antitoxin RNA pairs safeguard CRISPR-Cas systems. Science. 2021;372(6541). Doi:10.1126/science.abe5601.

Cheng F, Wang R, Yu H, Liu C, Yang J, Xiang H*, Li M*. Divergent degeneration of creA antitoxin genes from minimal CRISPRs and the convergent strategy of tRNA-sequestering CreT toxins. Nucleic Acids Research. 2021;49(18):10677-88. Doi:10.1093/nar/gkab821.

Lin L, Chen J, Mitra R, Gao Q, Cheng F, Xu T, Zuo Z, Xiang H*, Han J*. Optimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux. Communications Biology. 2021;4(1):1007. Doi:10.1038/s42003-021-02541-z.

Xue Q, Zhao D*, Zhang S, Zhou H, Zuo Z, Zhou J, Li M, Xiang H*. Highly integrated adaptive mechanisms in Spiribacter halalkaliphilus, a bacterium abundant in Chinese soda-saline lakes. Environmental Microbiology. 2021;23(11):6463-82. Doi:10.1111/1462-2920.15794.

Chen S, Sun S, Wang R, Feng H, Xiang H*. Halolysin R4 of Haloferax mediterranei confers its host antagonistic and defensive activities. Applied and Environmental Microbiology. 2021;87(8). Doi:10.1128/AEM.02889-20.

Zhang M, Xue Q, Zhang S, Zhou H, Xu T, Zhou J, Zheng Y, Li M, Kumar S, Zhao D*, Xiang H*. Development of whole-cell catalyst system for sulfide biotreatment based on the engineered haloalkaliphilic bacterium. AMB Express. 2021;11(1):142. Doi:10.1186/s13568-021-01302-9.

Mitra R, Xiang H*, Han J*. Current advances towards 4-hydroxybutyrate containing polyhydroxyalkanoates production for biomedical applications. Molecules. 2021;26(23). Doi:10.3390/molecules26237244.

Xue Q, Zuo Z, Zhou H, Zhou J, Zhang S, Han J, Zhao D, Xiang H*. Salinadaptatus halalkaliphilus gen. nov., sp. nov., a haloalkaliphilic archaeon isolated from salt pond in Inner Mongolia Autonomous Region, China. International Journal of Systematic and Evolutionary Microbiology. 2021;71(1). Doi:10.1099/ijsem.0.004584.

Zuo Z, Zhao D, Zhou J, Han J, Xiang H*. Halalkalirubrum salinum gen. nov., sp. nov., a halophilic archaeon isolated from a saline lake. Antonie Van Leeuwenhoek. 2021;114(1):83-94. Doi:10.1007/s10482-020-01502-6.

Xue Q, Zhao D, Zuo Z, Zhou J, Xiang H*. Natronorubrum halalkaliphilum sp. nov., a haloalkaliphilic archaeon isolated from soda lake in Inner Mongolia Autonomous Region, China. Archives of Microbiology. 2021;203(5):2335-42. Doi:10.1007/s00203-021-02207-8.

[2020]

Chen J, Mitra R, Xiang H*, Han J*. Deletion of the pps-like gene activates the cryptic phaC genes in Haloferax mediterranei. Applied Microbiology and Biotechnology. 2020;104(22):9759-71. Doi:10.1007/s00253-020-10898-0.

Mitra R, Xu T, Xiang H*, Han J*. Current developments on polyhydroxyalkanoates synthesis by using halophiles as a promising cell factory. Microbial Cell Factories. 2020;19(1):86. Doi:10.1186/s12934-020-01342-z.

Kim HS, Chen J, Wu LP, Wu J, Xiang H*, Leong KW, Han J*. Prevention of excessive scar formation using nanofibrous meshes made of biodegradable elastomer poly(3-hydroxybutyrate-co-3-hydroxyvalerate). Journal of Tissue Engineering. 2020;11:2041731420949332. Doi:10.1177/2041731420949332.

Zhao D, Zhang S, Xue Q, Chen J, Zhou J, Cheng F, Li M, Zhu Y, Yu H, Hu S, Zheng Y, Liu S, Xiang H*. Abundant taxa and favorable pathways in the microbiome of soda-saline lakes in Inner Mongolia. Frontiers in Microbiology. 2020;11:1740. Doi:10.3389/fmicb.2020.01740.

Kumar S, Zhou J, Li M, Xiang H*, Zhao D*. Insights into the metabolism pathway and functional genes of long-chain aliphatic alkane degradation in haloarchaea. Extremophiles. 2020;24(4):475-83. Doi:10.1007/s00792-020-01167-z.

[2019]

Gong L, Li M, Cheng F, Zhao D, Chen Y, Xiang H*. Primed adaptation tolerates extensive structural and size variations of the CRISPR RNA guide in Haloarcula hispanica. Nucleic Acids Research. 2019;47(11):5880-91. Doi:10.1093/nar/gkz244.

Xu Z, Li M, Li Y, Cao H, Miao L, Xu Z, Higuchi Y, Yamasaki S, Nishino K, Woo PCY, Xiang H*, Yan A*. Native CRISPR-Cas-mediated genome editing enables dissecting and sensitizing clinical multidrug-resistant P. aeruginosa. Cell Reports. 2019;29(6):1707-17 e3. Doi:10.1016/j.celrep.2019.10.006.

Chen J, Mitra R, Zhang S, Zuo Z, Lin L, Zhao D, Xiang H*, Han J*. Unusual phosphoenolpyruvate (PEP) synthetase-like protein crucial to enhancement of polyhydroxyalkanoate accumulation in Haloferax mediterranei revealed by dissection of PEP-pyruvate interconversion mechanism. Applied and Environmental Microbiology. 2019;85(19). Doi:10.1128/AEM.00984-19.

Chen S, Sun S, Korfanty GA, Liu J, Xiang H*. A halocin promotes DNA uptake in Haloferax mediterranei. Frontiers in Microbiology. 2019;10:1960. Doi:10.3389/fmicb.2019.01960.

[2018]

Xue Q, Liu X, Lao Y, Wu L, Wang D, Zuo Z, Chen J, Hou J, Bei Y, Wu X, Leong KW, Xiang H, Han J*. Anti-infective biomaterials with surface-decorated tachyplesin I. Biomaterials. 2018;178:351-62. Doi:10.1016/j.biomaterials.2018.05.008.

Zuo Z, Xue Q, Zhou J, Zhao D, Han J, Xiang H*. Engineering Haloferax mediterranei as an efficient platform for high level production of lycopene. Frontiers in Microbiology. 2018;9:2893. Doi:10.3389/fmicb.2018.02893.

Li M, Cheng F, Gong L, Xiang H*. [Systematic discovery of novel prokaryotic defense systems: progress and prospects]. Yi Chuan. 2018;40(4):259-65. Doi:10.16288/j.yczz.18-075.

[2017]

Li M, Gong L, Zhao D, Zhou J, Xiang H*. The spacer size of I-B CRISPR is modulated by the terminal sequence of the protospacer. Nucleic Acids Research. 2017;45(8):4642-54. Doi:10.1093/nar/gkx229.

Han J, Wu L, Liu X, Hou J, Zhao L, Chen J, Zhao D, Xiang H*. Biodegradation and biocompatibility of haloarchaea-produced poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymers. Biomaterials. 2017;139:172-86. Doi:10.1016/j.biomaterials.2017.06.006.

Cheng F, Gong L, Zhao D, Yang H, Zhou J, Li M, Xiang H*. Harnessing the native type I-B CRISPR-Cas for genome editing in a polyploid archaeon. Journal of Genetics and Genomics. 2017;44(11):541-8. Doi:10.1016/j.jgg.2017.09.010.

Liu J, Wang Q, Jiang X, Yang H, Zhao D, Han J, Luo Y, Xiang H*. Systematic analysis of lysine acetylation in the halophilic archaeon Haloferax mediterranei. Journal of Proteome Research. 2017;16(9):3229-41. Doi:10.1021/acs.jproteome.7b00222.

Zhao D, Yang H, Chen J, Cheng F, Kumar S, Han J, Li M, Zhou J, Xiang H*. Development of the first gene expression system for Salinicoccus strains with potential application in bioremediation of hypersaline wastewaters. Applied Microbiology and Biotechnology. 2017;101(19):7249-58. Doi:10.1007/s00253-017-8428-9.

Zhao D, Kumar S, Zhou J, Wang R, Li M, Xiang H*. Isolation and complete genome sequence of Halorientalis hydrocarbonoclasticus sp. nov., a hydrocarbon-degrading haloarchaeon. Extremophiles. 2017;21(6):1081-90. Doi:10.1007/s00792-017-0968-5.

[2016]

Wang R, Li M, Gong L, Hu S, Xiang H*. DNA motifs determining the accuracy of repeat duplication during CRISPR adaptation in Haloarcula hispanica. Nucleic Acids Research. 2016;44(9):4266-77. Doi:10.1093/nar/gkw260.

Liu X, Wu L, Hou J, Chen J, Han J*, Xiang H*. Environmental biodegradation of haloarchaea-produced poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in activated sludge. Applied Microbiology and Biotechnology. 2016;100(15):6893-902. Doi:10.1007/s00253-016-7528-2.

Liu G, Cai S, Hou J, Zhao D, Han J, Zhou J, Xiang H*. Enoyl-CoA hydratase mediates polyhydroxyalkanoate mobilization in Haloferax mediterranei. Scientific Reports. 2016;6:24015. Doi:10.1038/srep24015.

Chen S, Liu H, Zhou J, Xiang H*. Haloparvum sedimenti gen. nov., sp. nov., a member of the family Haloferacaceae. International Journal of Systematic and Evolutionary Microbiology. 2016;66(6):2327-34. Doi:10.1099/ijsem.0.001033.

Chen S, Liu H, Zhou J, Xiang H*. Halorubrum pallidum sp. nov., an extremely halophilic archaeon isolated from a subterranean rock salt. International Journal of Systematic and Evolutionary Microbiology. 2016;66(8):2980-6. Doi:10.1099/ijsem.0.001129.

Chen S, Wang C, Xiang H*. Sequence analysis and minimal replicon determination of a new haloarchaeal plasmid pHF2 isolated from Haloferax sp. strain Q22. Plasmid. 2016;83:1-7. Doi:10.1016/j.plasmid.2015.11.001.

Xiang H*. 2016. PHBHV biosynthesis by Haloferax mediterranei: from genetics, metabolism, and engineering to economical production. Recent Advances in Biotechnology (Martin Koller Ed. Bentham Science Publishers), 2016, 348-379.

[2015]

Yang H, Wu Z, Liu J, Liu X, Wang L, Cai S, Xiang H*. Activation of a dormant replication origin is essential for Haloferax mediterranei lacking the primary origins. Nature Communications. 2015;6:8321. Doi:10.1038/ncomms9321.

Han J, Wu LP, Hou J, Zhao D, Xiang H*. Biosynthesis, characterization, and hemostasis potential of tailor-made poly(3-hydroxybutyrate-co-3-hydroxyvalerate) produced by Haloferax mediterranei. Biomacromolecules. 2015;16(2):578-88. Doi:10.1021/bm5016267.

Cai S, Cai L, Zhao D, Liu G, Han J, Zhou J, Xiang H*. A novel DNA-binding protein, PhaR, plays a central role in the regulation of polyhydroxyalkanoate accumulation and granule formation in the haloarchaeon Haloferax mediterranei. Applied and Environmental Microbiology. 2015;81(1):373-85. Doi:10.1128/AEM.02878-14.

Hou J, Xiang H*, Han J*. Propionyl coenzyme A (propionyl-CoA) carboxylase in Haloferax mediterranei: Indispensability for propionyl-CoA assimilation and impacts on global metabolism. Applied and Environmental Microbiology. 2015;81(2):794-804. Doi:10.1128/AEM.03167-14.

Liu G, Hou J, Cai S, Zhao D, Cai L, Han J, Zhou J, Xiang H*. A patatin-like protein associated with the polyhydroxyalkanoate (PHA) granules of Haloferax mediterranei acts as an efficient depolymerase in the degradation of native PHA. Applied and Environmental Microbiology. 2015;81(9):3029-38. Doi:10.1128/AEM.04269-14.

Chen S, Liu HC, Zhao D, Yang J, Zhou J, Xiang H*. Halorubrum yunnanense sp. nov., isolated from a subterranean salt mine. International Journal of Systematic and Evolutionary Microbiology. 2015;65(12):4526-32. Doi:10.1099/ijsem.0.000605.

[2014]

Wu Z, Liu J, Yang H, Liu H, Xiang H*. Multiple replication origins with diverse control mechanisms in Haloarcula hispanica. Nucleic Acids Research. 2014;42(4):2282-94. Doi:10.1093/nar/gkt1214.

Li M, Wang R, Zhao D, Xiang H*. Adaptation of the Haloarcula hispanica CRISPR-Cas system to a purified virus strictly requires a priming process. Nucleic Acids Research. 2014;42(4):2483-92. Doi:10.1093/nar/gkt1154.

Li M, Wang R, Xiang H*. Haloarcula hispanica CRISPR authenticates PAM of a target sequence to prime discriminative adaptation. Nucleic Acids Research. 2014;42(11):7226-35. Doi:10.1093/nar/gku389.

Cai L, Cai S, Zhao D, Wu J, Wang L, Liu X, Li M, Hou J, Zhou J, Liu J, Han J, Xiang H*. Analysis of the transcriptional regulator GlpR, promoter elements, and posttranscriptional processing involved in fructose-induced activation of the phosphoenolpyruvate-dependent sugar phosphotransferase system in Haloferax mediterranei. Applied and Environmental Microbiology. 2014;80(4):1430-40. Doi:10.1128/AEM.03372-13.

Hou J, Han J, Cai L, Zhou J, Lu Y, Jin C, Liu J, Xiang H*. Characterization of genes for chitin catabolism in Haloferax mediterranei. Applied Microbiology and Biotechnology. 2014;98(3):1185-94. Doi:10.1007/s00253-013-4969-8.

Wu Z, Yang H, Liu J, Wang L, Xiang H*. Association between the dynamics of multiple replication origins and the evolution of multireplicon genome architecture in haloarchaea. Genome Biology and Evolution. 2014;6(10):2799-810. Doi:10.1093/gbe/evu219.

Wu Z, Liu J, Yang H, Xiang H*. DNA replication origins in archaea. Frontiers in Microbiology. 2014;5:179. Doi:10.3389/fmicb.2014.00179.

申请或授权专利

　　1.向华，周梅先等《一株嗜盐碱杆菌及其专有质粒与应用》

　　(专利号：ZL02100714.4），2004.11.24授权。

　　2.向华，孙超岷《一种极端嗜盐古菌质粒及其衍生质粒载体》

　　(专利号：ZL2004100497519），2008.10.1授权。

　　3.向华，任媛媛等《一种热稳定海藻糖合成酶及其编码基因与应用》

　　(专利号：ZL200410073883.5），2007.11.7授权。

　　4.向华，厉云等《一种嗜盐菌素及其免疫蛋白和它们的编码基因与应用》

　　(专利号：ZL200510055640.3），2009.2.18授权。

　　5.向华，周利刚等《表达极端嗜盐古菌紫膜蛋白突变体的载体及工程菌》

　　(专利号：ZL200510087721.1），2007.4.4授权。

　　6.向华，韩静等《极端嗜盐古菌聚羟基脂肪酸酯合酶及其编码基因与应用》

　　(专利号：ZL200710119986.4)，2012年1月4日授权。

　　7.向华，陆秋鹤等《一种与聚羟基丁酸戊酸共聚酯合成相关的酶及其编码基因与应用》

　　(专利号：ZL200810101529），2011年7月27日授权。

　　8.向华，冯博等《一种与PHBV的3-HV单体合成相关的β-酮硫解酶及其编码基因与应用》

　　(专利号：ZL201010195738.X），2012年4月3日授权。

　　9.向华，刘海龙《一种基于地中海富盐菌和pyrF基因的遗传操作系统及其应用》

　　(专利号：ZL201110054456.2)），2014年1月1日授权。

　　10.向华，刘海龙《一种基于西班牙盐盒菌和pyrF基因的遗传操作系统及其应用》

　　(专利号：ZL201110054379.0)，2014年3月26日授权。

　　11.向华，赵大贺《高效利用碳源生产生物塑料PHBV的极端嗜盐古菌工程菌》

　　(专利号：ZL2012 1 0181052.4)， 2015年6月10日授权。

　　12.韩静，向华，侯靖.国家发明专利《一种PHBV聚合物、制备方法及利用PHBV聚合物制作的止血材料》

    (专利号：ZL 2014 1 0658043.9）,2017年1月4日授权。

　　13.向华，刘桂明，韩静，赵大贺《一种聚羟基烷酸颗粒降解酶其用途及(R)-3HB生产方法》

    (专利号：ZL 2015 1 0056342.X)，2019年6月4日授权。

　　14.赵大贺，周坚，向华《一株耐高盐耐高COD盐水球菌菌株和来源该菌株的内源质粒》

    (专利号：ZL201610951864.0)，2019年10月11日授权。

    15.赵大贺，向华，周坚，苏米特·库玛 《一株在高盐条件下降解烷烃的盐东方菌菌株及其培养方法》

    (专利号：ZL201710199115.1)，2020年1月7日授权。

    16.韩静，向华，刘晓斌，薛琼《一种PhaP-Tac的微生物合成及其对疏水材料PHBV的修饰方法》

    (专利号：ZL201810417080.9），2021年2月19日授权。

    17.韩静，向华，徐桐，陈国强《一种具有自絮凝能力的菌株及其制备方法与应用》

    (专利号：ZL 202011572752.7），2024年4月16日授权。

    18.韩静，向华，林琳《一种重组地中海富盐菌及其在制备PHBV中的应用》

    (专利号：ZL202011277922.9），2024年5月24日授权。

    19.向华，韩静，林琳《一种抑制地中海富盐菌中目的基因表达的方法》

    (专利号：ZL202011277932.2），2024年5月28日授权。

    20.向华，杜开心，龚路遥，李明《一种利用I型CRISPR-Cas系统同时实现基因编辑和转录调控的方法》

    (专利号：ZL202011546641.9），2024年7月19日授权。

    21.向华，李明，程飞跃，龚路遥《一种古菌和细菌中通用的RNA型毒素及其相关生物材料》

    (专利号：ZL202011320316.0），2024年7月23日授权。

    22.向华，赵大贺，张满琪《高效生物氧化脱硫的盐单胞菌工程菌株及其全细胞催化脱硫方法》

    (专利申请号：202110819056.X）。

    23.韩静，向华，徐桐，陈国强《一种双sgRNA结合RecET系统实现盐单胞菌大片段DNA的敲除方法》

    (专利申请号：202110011391.7）。

    24.韩静，向华，徐桐，陈国强《一种提高盐单胞菌转化效率的方法及所得菌株与应用》

    (专利申请号：202211421595.9）。

    25.向华，陈军玉，韩静，徐桐《一种利用地中海富盐菌CRISPR-Cas系统实现基因编辑及提高PHBV产量的方法》

    (专利申请号：202310270703.5）。

    26.向华，赵大贺，安鹏《微杆菌QXD-8 及其在降解羧甲基纤维素钠中的应用》

    (专利申请号：202311204748.9）。

    27.向华，韩静，徐桐，李浩，薛琼，赵大贺《一种能够利用多种碳源的盐单胞菌及其在发酵生产聚羟基脂肪酸酯中的应用》

    (专利申请号：202410081650.7）。

    28.向华，郭京，龚路遥《调控真核细胞基因转录的I-F2型CRISPR-Cas系统及其应用》

    (专利申请号：202211702167.3，PCT/CN2022/143090）。

    29.向华，郭京，龚路遥，禹海英《一种精简的I型CRISPR-Cas效应复合物及其应用》

    (专利申请号：PCT/CN2024/074258）。

    30.向华，龚路遥，禹海英，刘振权《一种基因编辑系统 CRISPR-Cas12p 及其应用》

    (专利申请号：202411597449.0）。