发表论文：

2025年

1.Yan, H.; Xin, Z.; Sang, Z.; Li, X.; Xie, J.; Wu, J.; Pang, S.; Wen, Y.; Wang, W. A Rational Multi-Target Combination Strategy for Synergistic Improvement of Non-Ribosomal Peptide Production. Nat. Commun. 2025, 16 (1). https://doi.org/10.1038/s41467-025-57073-5.

2.Wang, H.; Wang, L.; Li, D.; Fan, K.; Yang, Y.; Cao, H.; Sun, J.; Ren, J.; Liu, Y.; Xiang, L.; Li, W.; Pan, M.; Hu, H.; Chen, Y.; Xu, Z.; Huang, Y.; Wang, W.; Pan, G. Uncovering the Molecular Landscape of Tetracycline Family Natural Products through Bacterial Genome Mining. J. Am. Chem. Soc. 2025, 147 (18), 15100–15114. https://doi.org/10.1021/jacs.4c17551.

3.Li, B.; Yang, Z.; Li, Z.; Zhang, Y.; Zhang, L.; Wang, W. Enabling Genetic Manipulation and Robustness of Bacillus Methanolicus for Methanol-Based Bio-Manufacturing. Metab. Eng. 2025, 89, 121–134. https://doi.org/10.1016/j.ymben.2025.02.013.

4.Yan, H.; Li, S.; Wang, W. Reprogramming Naturally Evolved Switches for Streptomyces Chassis Development. Trends Biotechnol. 2025, 43 (1), 12–15. https://doi.org/10.1016/j.tibtech.2024.07.001.

2024年

5.He, X.; Wang, D.; Liu, J.; Shi, T.; Wang, W.; Chen, B.; Li, D.; Zhang, L.; Tan, G. Y. Engineering the Methylerythritol Phosphate Pathway and Using a Temporal Promoter for Enhanced Lycopene Production in Rhodobacter Sphaeroides HY01. J. Agric. Food Chem. 2024. https://doi.org/10.1021/ACS.JAFC.4C07848/SUPPL_FILE/JF4C07848_SI_001.PDF.

6.Yang, Z.; Li, B.; Bu, R.; Wang, Z.; Xin, Z.; Li, Z.; Zhang, L.; Wang, W. A Highly Efficient Method for Genomic Deletion across Diverse Lengths in Thermophilic Parageobacillus Thermoglucosidasius. Synth. Syst. Biotechnol. 2024, 9 (4), 658–666. https://doi.org/10.1016/j.synbio.2024.05.009.

7.Zhou, H.; Zhang, C.; Li, Z.; Xia, M.; Li, Z.; Wang, Z.; Tan, G. Y.; Luo, Y.; Zhang, L.; Wang, W. Systematic Development of a Highly Efficient Cell Factory for 5-Aminolevulinic Acid Production. Trends Biotechnol. 2024. https://doi.org/10.1016/j.tibtech.2024.06.004.

8.Zhang, M.; Shi, H.; Wang, X.; Zhu, Y.; Li, Z.; Tu, L.; Zheng, Y.; Xia, M.; Wang, W.; Wang, M. AI-Based Automated Construction of High-Precision Geobacillus Thermoglucosidasius Enzyme Constraint Model. Metab. Eng. 2024, 86, 208–233. https://doi.org/10.1016/j.ymben.2024.10.006.

9.Wang, J.; Wang, W.; Chen, Y.; Liu, Z.; Ji, X.; Pan, G.; Li, Z.; Fan, K. Development of a Xylose-Inducible and Glucose-Insensitive Expression System for Parageobacillus Thermoglucosidasius. Appl. Microbiol. Biotechnol. 2024, 108 (1), 493. https://doi.org/10.1007/s00253-024-13333-w.

10.Wang, S.; Zeng, X.; Jiang, Y.; Wang, W.; Bai, L.; Lu, Y.; Zhang, L.; Tan, G. Y. Unleashing the Potential: Type I CRISPR-Cas Systems in Actinomycetes for Genome Editing. Nat. Prod. Rep. 2024. https://doi.org/10.1039/d4np00010b.

11.Sang, Z.; Li, X.; Yan, H.; Wang, W.; Wen, Y. Development of a Group II Intron-Based Genetic Manipulation Tool for Streptomyces. Microb. Biotechnol. 2024, 17 (5). https://doi.org/10.1111/1751-7915.14472.

12.Qiu, S.; Yang, B.; Li, Z.; Li, S.; Yan, H.; Xin, Z.; Liu, J.; Zhao, X.; Zhang, L.; Xiang, W.; Wang, W. Building a Highly Efficient Streptomyces Super-Chassis for Secondary Metabolite Production by Reprogramming Naturally-Evolved Multifaceted Shifts. Metab. Eng. 2024, 81, 210–226. https://doi.org/10.1016/j.ymben.2023.12.007.

13.Shi, X.; Yan, H.; Yuan, F.; Li, G.; Liu, J.; Li, C.; Yu, X.; Li, Z.; Zhu, Y.; Wang, W. LexA, an SOS Response Repressor, Activates TGase Synthesis in Streptomyces Mobaraensis. Front. Microbiol. 2024, 15. https://doi.org/10.3389/fmicb.2024.1397314.

14.Chen, H.; Wang, Y.; Wang, W.; Cao, T.; Zhang, L.; Wang, Z.; Chi, X.; Shi, T.; Wang, H.; He, X.; Liang, M.; Yang, M.; Jiang, W.; Lv, D.; Yu, J.; Zhu, G.; Xie, Y.; Gao, B.; Wang, X.; Liu, X.; Li, Y.; Ouyang, L.; Zhang, J.; Liu, H.; Li, Z.; Tong, Y.; Xia, X.; Tan, G. Y.; Zhang, L. High-Yield Porphyrin Production through Metabolic Engineering and Biocatalysis. Nat. Biotechnol. 2024. https://doi.org/10.1038/s41587-024-02267-3.

2023年

15.Yang, Z.; Li, Z.; Li, B.; Bu, R.; Tan, G. Y.; Wang, Z.; Yan, H.; Xin, Z.; Zhang, G.; Li, M.; Xiang, H.; Zhang, L.; Wang, W. A Thermostable Type I-B CRISPR-Cas System for Orthogonal and Multiplexed Genetic Engineering. Nat. Commun. 2023, 14 (1). https://doi.org/10.1038/s41467-023-41973-5.

16.Li, S.; Li, Z.; Tan, G. Y.; Xin, Z.; Wang, W. In Vitro Allosteric Transcription Factor-Based Biosensing. Trends Biotechnol. 2023, 41 (8), 1080–1095. https://doi.org/10.1016/j.tibtech.2023.03.001.

2022年

17.Wang, J.; Li, Z.; Wang, W.; Pang, S.; Yao, Y.; Yuan, F.; Wang, H.; Xu, Z.; Pan, G.; Liu, Z.; Chen, Y.; Fan, K. Dynamic Control Strategy to Produce Riboflavin with Lignocellulose Hydrolysate in the Thermophile Geobacillus Thermoglucosidasius. ACS Synth. Biol. 2022, 11 (6), 2163–2174. https://doi.org/10.1021/acssynbio.2c00087.

18.Liang, M.; Liu, L.; Xu, F.; Zeng, X.; Wang, R.; Yang, J.; Wang, W.; Karthik, L.; Liu, J.; Yang, Z.; Zhu, G.; Wang, S.; Bai, L.; Tong, Y.; Liu, X.; Wu, M.; Zhang, L.-X.; Tan, G.-Y. Activating Cryptic Biosynthetic Gene Cluster through a CRISPR–Cas12a-Mediated Direct Cloning Approach. Nucleic Acids Res. 2022, 50 (6), 3581–3592. https://doi.org/10.1093/nar/gkac181.

19.Li, Z.; Zhang, C.; Wang, Z.; Li, C.; Yang, Z.; Li, Z.; Zhang, L.; Wang, W. High-Throughput and Reliable Acquisition of in Vivo Turnover Number Fuels Precise Metabolic Engineering. Synth. Syst. Biotechnol. 2022, 7 (1), 541–543. https://doi.org/10.1016/j.synbio.2021.12.006.

2021年

20.Zhao, X.; Wang, Z.; Yang, B.; Li, Z.; Tong, Y.; Bi, Y.; Li, Z.; Xia, X.; Chen, X.; Zhang, L.; Wang, W.; Tan, G. Y. Integrating PCR-Free Amplification and Synergistic Sensing for Ultrasensitive and Rapid CRISPR/Cas12a-Based SARS-CoV-2 Antigen Detection. Synth. Syst. Biotechnol. 2021, 6 (4), 283–291. https://doi.org/10.1016/j.synbio.2021.09.007.

21.Li, S.; Yang, B.; Tan, G. Y.; Ouyang, L. M.; Qiu, S.; Wang, W.; Xiang, W.; Zhang, L. Polyketide Pesticides from Actinomycetes. Curr. Opin. Biotechnol. 2021, 69, 299–307. https://doi.org/10.1016/J.COPBIO.2021.05.006,.

22.Li, S.; Li, Z.; Pang, S.; Xiang, W.; Wang, W. Coordinating Precursor Supply for Pharmaceutical Polyketide Production in Streptomyces. Curr. Opin. Biotechnol. 2021, 69, 26–34. https://doi.org/10.1016/j.copbio.2020.11.006.

23.Yang, Y.; Sun, Q.; Liu, Y.; Yin, H.; Yang, W.; Wang, Y.; Liu, Y.; Li, Y.; Pang, S.; Liu, W.; Zhang, Q.; Yuan, F.; Qiu, S.; Li, J.; Wang, X.; Fan, K.; Wang, W.; Li, Z.; Yin, S. Development of a pyrF-Based Counterselectable System for Targeted Gene Deletion in Streptomyces Rimosus. J. Zhejiang Univ. Sci. B 2021, 22 (5), 383–396. https://doi.org/10.1631/jzus.B2000606.

24.Yang, Z.; Sun, Q.; Tan, G.; Zhang, Q.; Wang, Z.; Li, C.; Qi, F.; Wang, W.; Zhang, L.; Li, Z. Engineering Thermophilic Geobacillus Thermoglucosidasius for Riboflavin Production. Microb. Biotechnol. 2021, 14 (2), 363–373. https://doi.org/10.1111/1751-7915.13543.

25.Shi, T.; Zhang, L.; Liang, M.; Wang, W.; Wang, K.; Jiang, Y.; Liu, J.; He, X.; Yang, Z.; Chen, H.; Li, C.; Lv, D.; Zhou, L.; Chen, B.; Li, D.; Zhang, L.-X.; Tan, G.-Y. Screening and Engineering of High-Activity Promoter Elements through Transcriptomics and Red Fluorescent Protein Visualization in Rhodobacter Sphaeroides. Synth. Syst. Biotechnol. 2021, 6, 335–342. https://doi.org/10.1016/j.synbio.2021.09.011.

2020年

26.Cao, Z.; Yu, J.; Wang, W.; Lu, H.; Xia, X.; Xu, H.; Yang, X.; Bao, L.; Zhang, Q.; Wang, H.; Zhang, S.; Zhang, L. Multi-Scale Data-Driven Engineering for Biosynthetic Titer Improvement. Curr. Opin. Biotechnol. 2020, 65, 205–212. https://doi.org/10.1016/J.COPBIO.2020.04.002.

27.Zhang, Q.; Ren, J. W.; Wang, W.; Zhai, J.; Yang, J.; Liu, N.; Huang, Y.; Chen, Y.; Pan, G.; Fan, K. A Versatile Transcription-Translation in One Approach for Activation of Cryptic Biosynthetic Gene Clusters. ACS Chem. Biol. 2020, 15 (9), 2551–2557. https://doi.org/10.1021/acschembio.0c00581.

28.Wang, W.; Li, S.; Li, Z.; Zhang, J.; Fan, K.; Tan, G.; Ai, G.; Lam, S. M.; Shui, G.; Yang, Z.; Lu, H.; Jin, P.; Li, Y.; Chen, X.; Xia, X.; Liu, X.; Dannelly, H. K.; Yang, C.; Yang, Y.; Zhang, S.; Alterovitz, G.; Xiang, W.; Zhang, L. Harnessing the Intracellular Triacylglycerols for Titer Improvement of Polyketides in Streptomyces. Nat. Biotechnol. 2020, 38 (1), 76–83. https://doi.org/10.1038/s41587-019-0335-4.

2019年

29.Wang X^#, Yin S^#, Bai J, Liu Y, Fan K, Wang H, Yuan F, Zhao B*, Li Z*, Wang W*: Heterologous production of chlortetracycline in an industrial grade Streptomyces rimosus host. Appl Microbiol Biotechnol 2019, 103(16):6645-6655.

30.Liang M^#, Li Z^#, Wang W^#, Liu J^#, Liu L, Zhu G, Karthik L, Wang M, Wang KF, Wang Z, Yu J, Shuai Y, Yu J, Zhang L, Yang Z, Li C, Zhang Q, Shi T, Zhou L, Xie F, Dai H, Liu X, Zhang J, Liu G, Zhuo Y, Zhang B, Liu C, Li S, Xia X, Tong Y, Liu Y, Alterovitz G, Tan G*, Zhang L*: A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules. Nat Commun 2019, 10(1):3672.

31.Wang J^#, Wang W, Wang H, Yuan F, Xu Z, Yang K, Li Z, Chen Y*, Fan K*: Improvement of stress tolerance and riboflavin production of Bacillus subtilis by introduction of heat shock proteins from thermophilic bacillus strains. Appl Microbiol Biotechnol 2019, 103(11):4455-4465.

2018年

32.Cao J^#, Yao Y^#, Fan K, Tan G, Xiang W, Xia X, Li S*, Wang W*, Zhang L*: Harnessing a previously unidentified capability of bacterial allosteric transcription factors for sensing diverse small molecules in vitro. Sci Adv 2018, 4(11):eaau4602.

33.Yao Y^#, Li S^#, Cao J, Liu W, Fan K, Xiang W, Yang K*, Kong D*, Wang W*: Development of small molecule biosensors by coupling the recognition of the bacterial allosteric transcription factor with isothermal strand displacement amplification. Chem Commun (Camb) 2018, 54(38):4774-4777.

34.Yao Y^#, Li S^#, Cao J, Liu W, Qi F, Xiang W, Yang K, Wang W*, Zhang L*: A novel signal transduction system for development of uric acid biosensors. Appl Microbiol Biotechnol 2018, 102(17):7489-7497.

35.Li S^#, Wang J^#, Xiang W, Yang K, Li Z*, Wang W*: An Autoregulated Fine-Tuning Strategy for Titer Improvement of Secondary Metabolites Using Native Promoters in Streptomyces. ACS Synth Biol 2018, 7(2):522-530.

2017年

36.Li X^#, Wang J, Shi M, Wang W, Corre C, Yang K*: Evidence for the formation of ScbR/ScbR2 heterodimers and identification of one of the regulatory targets in Streptomyces coelicolor. Appl Microbiol Biotechnol 2017, 101(13):5333-5340.

37.Li S^#, Zhou L, Yao Y, Fan K, Li Z, Zhang L, Wang W*, Yang K*: A platform for the development of novel biosensors by configuring allosteric transcription factor recognition with amplified luminescent proximity homogeneous assays. Chem Commun (Camb) 2017, 53(1):99-102.

2016年

38.Wang W^#, Yang T^#, Li Y, Li S, Yin S, Styles K, Corre C, Yang K*: Development of a Synthetic Oxytetracycline-Inducible Expression System for Streptomycetes Using de Novo Characterized Genetic Parts. ACS Synth Biol 2016, 5(7):765-773.

39.Yin S^#, Li Z^#, Wang X, Wang H, Jia X, Ai G, Bai Z, Shi M, Yuan F, Liu T, Wang W*, Yang K*: Heterologous expression of oxytetracycline biosynthetic gene cluster in Streptomyces venezuelae WVR2006 to improve production level and to alter fermentation process. Appl Microbiol Biotechnol 2016, 100(24):10563-10572.

40.Jiang T^#, Ke B, Chen H, Wang W, Du L, Yang K, Li M*: Bioluminescent Probe for Detecting Mercury(II) in Living Mice. Anal Chem 2016, 88(15):7462-7465.

41.Sidda JD^#, Poon V, Song L, Wang W, Yang K, Corre C*: Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production superhost Streptomyces M1152. Org Biomol Chem 2016, 14(27):6390-6393.

42.Jiang T^#, Wang W, Wu X, Wu W, Bai H, Ma Z, Shen Y, Yang K*, Li M*: Discovery of New Substrates for LuxAB Bacterial Bioluminescence. Chem Biol Drug Des 2016, 88(2):197-208.

2015年

43.Li S^#, Wang J^#, Li X, Yin S, Wang W*, Yang K*: Genome-wide identification and evaluation of constitutive promoters in streptomycetes. Microb Cell Fact 2015, 14(1):172.

44.Li S^#, Wang W^#, Li X, Fan K, Yang K*: Genome-wide identification and characterization of reference genes with different transcript abundances for Streptomyces coelicolor. Sci Rep 2015, 5:15840.

45.Li X^#, Wang J, Li S, Ji J, Wang W*, Yang K*: ScbR- and ScbR2-mediated signal transduction networks coordinate complex physiological responses in Streptomyces coelicolor. Sci Rep 2015, 5:14831.

46.Wang W^#, Li X^#, Li Y, Li S, Fan K, Yang K*: A genetic biosensor for identification of transcriptional repressors of target promoters. Sci Rep 2015, 5:15887.

47.Yin S^#, Wang W^#, Wang X, Zhu Y, Jia X, Li S, Yuan F, Zhang Y*, Yang K*: Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus. Microb Cell Fact 2015, 14(1):46.

2014年

48.Wang W^#, Ji J^#, Li X, Wang J, Li S, Pan G, Fan K, Yang K*: Angucyclines as signals modulate the behaviors of Streptomyces coelicolor. Proc Natl Acad Sci U S A 2014, 111(15):5688-5693.

2013年

49.Wang W^#, Li X^#, Wang J, Xiang S, Feng X, Yang K*: An engineered strong promoter for streptomycetes. Appl Environ Microbiol 2013, 79(14):4484-4492.

50.Liu Z^#, Wang W, Zhu Y, Gong Q, Yu W*, Lu X*: Antibiotics at subinhibitory concentrations improve the quorum sensing behavior of Chromobacterium violaceum. FEMS Microbiol Lett 2013, 341(1):37-44.

2012年

51.Fan K^#, Pan G^#, Peng X, Zheng J, Gao W, Wang J, Wang W, Li Y, Yang K*: Identification of JadG as the B ring opening oxygenase catalyzing the oxidative C-C bond cleavage reaction in jadomycin biosynthesis. Chem Biol 2012, 19(11):1381-1390.

2011年

52.Wang J^#, Wang W^#, Wang L, Zhang G, Fan K, Tan H, Yang K*: A novel role of 'pseudo'gamma-butyrolactone receptors in controlling gamma-butyrolactone biosynthesis in Streptomyces. Mol Microbiol 2011, 82(1):236-250.

申请专利：

1.基于适配体和CRISPR/Cas12a系统的生物传感器、组合物、试剂盒及其用途；发明人：张立新 王为善 谭高翼 赵祥祥 杨博文 王正铎 李子龙；专利申请号：申请号：2021104385662；申请日：2021.04.22

2.产土霉素的工程菌及其构建方法与应用，李子龙、刘文溪、王为善、闫浩，申请号：2022102726313，申请日期：2022.03.18

3.提高热葡糖苷酶地芽孢杆菌转化效率的方法，李子龙、王为善、卜瑞红、杨志恒，申请号：2023102487444，申请日期：2023.03.15

4.热葡糖苷酶地芽孢杆菌CRISPR type I-B 基因编辑及其应用，王为善、杨志恒、李子龙、卜瑞红，申请号：202310705228X，申请日期：2023.06.14

5.高产卟啉化合物的菌株改造策略及工程菌株，谭高翼，张立新，陈海红，石桐，王为善，王正铎，何昕蔚，江雯亦，杨梦雪，池旭冉，张璐，王煌炜，申请号：2023107389151， 申请日期：2023.06.20

6.一种卟啉化合物发酵工艺及控制策略， 谭高翼，张立新，陈海红，王为善，王正铎，梁敏东，王煌炜，吕东源， 申请号：2023107502633， 申请日期：2023.06.21

7.卟啉化合物的高产策略及其应用， 谭高翼，张立新，陈海红，王为善，王正铎，江雯亦，杨梦雪，池旭冉，王煌炜， 申请号：2023107374298， 申请日期：2023.06.20

8.通用的金属卟啉化合物生产平台、其建立方法及应用， 谭高翼，张立新，陈海红，王为善，王正铎，曹婷，王煌炜， 申请号：202310754364.8， 申请日期：2023.06.25

9.基于二型内含子打靶的链霉菌遗传操作工具构建与应用，王为善，桑紫薇，李子龙，闫浩，申请号：2024103009622，申请日期：2024.03.15

10.一组5-氨基乙酰丙酸合酶及其应用，王为善，李子龙，周厚明，张承昱，罗莹，申请号：2024105844414，申请日期：2024.05.11

11.高产 5-氨基乙酰丙酸的大肠杆菌工程菌及其构建方法与应用，王为善，李子龙，罗莹，周厚明，张承昱，申请号：2024105844397，申请日期：2024.05.11

12.一种提高甲醇芽孢杆菌电转化效率的方法，王为善，杨志恒，李碧霄，李子龙，申请号：2025101669745，申请日期：2025.02.14

13.一种提高甲醇芽孢杆菌生物量和蛋白含量的方法，王为善，杨志恒，李碧霄，李子龙，申请号：2025101669641，申请日期：2025.02.14

14.高产核黄素的甲醇芽孢杆菌工程菌及其构建方法与应用，王为善，杨志恒，李碧霄，李子龙，申请号：2025101670047，申请日期：2025.02.14

15.非核糖体肽高产菌株的筛选与改造方法， 王为善，闫浩，李子龙，辛振国，李茜，申请号：2025101757267， 申请日期：2025.02.18

16.一种提高玫瑰孢链霉菌达托霉素产量的方法，王为善，闫浩，李子龙，辛振国，李茜，申请号：2025101757290，申请日期：2025.02.18

17.一种协调链霉菌次级代谢物生产的动态控制系统及其应用，王为善，杨博文，李子龙，申请号：2025105691339，申请日期：2025.04.30

18.高产阿维菌素B2a的基因工程菌及其构建方法与应用，王为善，杨博文，李子龙，申请号：2025105691343，申请日期：2025.04.30

19.一种热葡糖苷酶地芽孢杆菌高效感受态细胞的构建方法与应用，王为善，王春晓，李子龙，李川，杨志恒，申请号：2025105845110，申请日期：2025.05.07

授权专利：

 1.利用土霉素正调控基因构建重组菌和提高土霉素产量的方法；发明人：杨克迁，王为善，尹守亮，王娟，王雪峰，贾晓乐，袁昉; 授权公告号：ZL2015100035363；申请日期：2015.01.04; 授权日期：2019.09.20；

2.嗜热菌来源的热激蛋白基因的应用；发明人：李子龙、王俊阳、范可强、 王为善、 王绘砖、 袁昉、徐珍；授权公告号 ZL2019101913185;申请日期：2019.03.13; 授权日期：2020.10.02  

3.包含别构转录因子调控系统的生物传感器、试剂盒及其在小分子检测中的用途。发明人：杨克迁；王为善；李珊珊；范可强；李子龙 ; 授权公告号 ZL2016109344916;申请日期：2016.10.25； 授权日期：2020.10.23 

4.包含别构转录因子调控系统的生物传感器、试剂盒及其在小分子检测中的用途；发明人：张立新，王为善，姚永鹏，曹佳倩，李珊珊，李子龙， ZL2018102248438 ;申请日期：2018.03.19； 授权日期：2021.03.09

5.一种提高链霉菌次级代谢产物产量的方法。发明人：李珊珊，向文胜，王为善，王俊阳；授权公告号  ZL201710953975X；申请日期：2017.10.13；授权日期：2020.11.03

6.热葡萄糖苷酶地芽孢杆菌工程菌及其构建方法及应用；发明人：李子龙、杨志恒、王为善、张立新，授权公告号 ZL202010015867X，申请日：2020.01.07；授权日期：2021.06.29

7.一种提高去甲四环素产量的方法；发明人：李子龙、张超波、庞申、范可强、 王为善、 王绘砖、 袁昉、徐珍；授权公告号 ZL2019106938808，申请日期：2019.07.30; 授权日期 2021.07.13

8.高温产核黄素的工程菌及其构建方法与应用；发明人：李子龙、齐凤仙、范可强、王为善、王俊阳、杨克迁；授权公告号 ZL2018103931111， 申请日期：2018.04.27; 授权日期 2021.11.05

9.提高链霉菌聚酮化合物产量的方法；发明人：张立新 王为善 李珊珊 李子龙 谭高翼 范可强 张敬宇；ZL2019100644213 （PCT：WO2020233506A1）；申请日：2019.05.17   授权日期 2023.01.10

10.基于CRISPR/Cas12a系统的生物传感器、试剂盒及其在小分子检测中的用途；发明人：张立新 谭高翼 梁敏东 王为善 刘家坤；ZL2019102856071（PCT：WO2020207453A1）；申请日：2019.04.10

11.链霉菌底盘菌株及其构建方法、在异源表达研究中的应用；发明人：王雪峰、王绘砖、袁昉、李子龙、尹守亮、王为善、范可强、赵宝华；ZL2019100644213， 申请日期：2019.01.23