代表性图片

　　A.

　　A. 铜绿假单胞菌生物被膜的发育周期及其相应阶段Psl多糖形成的基质网的变化。

　　红色：Psl多糖； 绿色：细菌细胞(Ma et. al. 2009 PLoS Pathogens)

　　B.

　　C.

　　B. 铜绿假单胞菌Biofilm中蜘蛛网形态的Psl多糖丝状网络 C. 四型菌毛介导的运动导致多糖丝状网络形成的模式图

　　红色：Psl多糖； 绿色：细菌细胞(Wang et. al., 2013 Environ Microbiol)

　　近期代表性论文（* 通讯作者）

　　1.Xu, A.^#, Wang, D. ^#, Ding, Y., Zheng, Y., Wang, B., Wei, Q., Wang, S., Yang, L. and Ma, L.Z.^* (2020) Integrated comparative genomic analysis and phenotypic profiling of Pseudomonas aeruginosa isolates from crude oil. Frontiers in Microbiology. 11:519.

　　2.Xu, A., Zhang, M., Du, W., Wang, D. ^* and Ma, L.Z.^* (2020) A molecular mechanism for how sigma factor AlgT and transcriptional regulator AmrZ inhibit twitching motility in Pseudomonas aeruginosa. Environmental Microbiology. doi:10.1111/1462-2920.14985

　　3.Wei, Q., Bhasme, P., Wang, Z., Wang, L., Wang, S., Zeng, Y., Wang, Y., Ma, L.Z. ^*and Li, Y^* (2020) Chinese medicinal herb extract inhibits PQS-mediated quorum sensing system in Pseudomonas aeruginosa. Journal of Ethnopharmacology, 248, 112272.

　　4.Bhasme, P., Wei, Q., Xu, A., Naqvi, S.T.A., Wang, D. and Ma, L.Z. ^* (2020) Evaluation and characterization of the predicted diguanylate cyclase-encoding genes in Pseudomonas aeruginosa. MicrobiologyOpen, 9(3): e975.

　　5.Zhao, T., Zhang, J., Tang, M., Ma, L.Z. ^* and Lei, X. ^* (2019) Development of an effective fluorescence probe for discovery of aminopeptidase inhibitors to suppress biofilm formation. The Journal of Antibiotics, 72, 461-468.

　　6.Wu, H., Wang, D., Tang, M. and Ma, L.Z. ^* (2019) The advance of assembly of exopolysaccharide Psl biosynthesis machinery in Pseudomonas aeruginosa. MicrobiologyOpen, 8(10): e857.

　　7.Wu, H., Qiao, S., Li, D., Guo, L., Zhu, M. and Ma, L.Z. ^* (2019) Crystal structure of the glycoside hydrolase PssZ from Listeria monocytogenes. Acta crystallographica. Section F, Structural Biology Communications, 75, 501-506.

　　8.Wei, Q., Leclercq, S., Bhasme, P., Xu, A., Zhu, B., Zhang, Y., Zhang, M., Wang, S. and Ma, L.Z. ^* (2019) Diguanylate Cyclases and Phosphodiesterases Required for Basal-Level c-di-GMP in Pseudomonas aeruginosa as Revealed by Systematic Phylogenetic and Transcriptomic Analyses. Applied and Environmental Microbiology, 16;85(21). pii: e01194-19

　　9.Liu, X., Wang, S., Xu, A., Zhang, L., Liu, H. and Ma, L.Z. ^* (2019) Biological synthesis of high-conductive pili in aerobic bacterium Pseudomonas aeruginosa. Applied Microbiology and Biotechnology, 103, 1535-1544.

　　10.Huang, Z., Wang, Y.H., Zhu, H.Z., Andrianova, E.P., Jiang, C.Y., Li, D., Ma, L., Feng, J., Liu, Z.P., Xiang, H^*. et al. (2019) Cross Talk between Chemosensory Pathways That Modulate Chemotaxis and Biofilm Formation. mBio, 10(1). pii: e02876-18.

　　11.Zhao, T., Zhang, Y., Wu, H., Wang, D., Chen, Y., Zhu, M.J. and Ma, L.Z. ^* (2018) Extracellular aminopeptidase modulates biofilm development of Pseudomonas aeruginosa by affecting matrix exopolysaccharide and bacterial cell death. Environmental Microbiology Reports, 10, 583-593.

　　12.Zhang, J., He, J., Zhai, C., Ma, L.Z., Gu, L. and Zhao, K. ^* (2018) Effects of PslG on the Surface Movement of Pseudomonas aeruginosa. Applied and Environmental Microbiology, 84.

　　13.Zhai, C., Zhang, W., Zhang, J., Ma, L.Z. and Zhao, K. ^* (2018) Overshadow Effect of Psl on Bacterial Response to Physiochemically Distinct Surfaces Through Motility-Based Characterization. Frontiers in Cellular and Infection Microbiology, 8, 383.

　　14.Jin, Z., Nie, M., Hu, R., Zhao, T., Xu, J., Chen, D., Yun, J., Ma, L.Z. and Du, W. ^* (2018) Dynamic Sessile-Droplet Habitats for Controllable Cultivation of Bacterial Biofilm. Small (Weinheim an der Bergstrasse, Germany), 14, e1800658.

　　15.Yu, S., Zhang, M. and Ma, L. ^* (2017) [Anti-biofilm effects of Zn lactate.3H(2)O and SnF(2) on Pseudomonas aeruginosa, Acinetobacter baumannii and Streptococcus mutans]. Sheng wu gong cheng xue bao = Chinese Journal of Biotechnology, 33, 1478-1488.

　　16.Yu, S. and Ma, L. ^* (2017) [Iron uptake and biofilm formation in Pseudomonas aeruginosa]. Sheng wu gong cheng xue bao = Chinese Journal of Biotechnology, 33, 1489-1512.

　　17.Wang, D., Xu, A., Elmerich, C. and Ma, L.Z. ^* (2017) Biofilm formation enables free-living nitrogen-fixing rhizobacteria to fix nitrogen under aerobic conditions. The ISME Journal, 11, 1602-1613.

　　18.Qian, W. , Ma, L., Gu, L. and Zhang, L. (2017) [Preface for special issue on biofilm and c-di-GMP--Microbial society, c-di-GMP regulation, and new research techniques]. Sheng wu gong cheng xue bao = Chinese Journal of Biotechnology, 33, 1351-1356.

　　19.Zhu, B., Liu, C., Liu, S., Cong, H., Chen, Y., Gu, L. and Ma, L.Z. ^* (2016) Membrane association of SadC enhances its diguanylate cyclase activity to control exopolysaccharides synthesis and biofilm formation in Pseudomonas aeruginosa. Environmental Microbiology, 18, 3440-3452.

　　20.Yu, S., Wei, Q., Zhao, T., Guo, Y. and Ma, L.Z. ^* (2016) A Survival Strategy for Pseudomonas aeruginosa That Uses Exopolysaccharides To Sequester and Store Iron To Stimulate Psl-Dependent Biofilm Formation. Applied and Environmental Microbiology, 82, 6403-6413.

　　21.Yu, S. ^#, Su, T. ^#, Wu, H., Liu, S., Wang, D., Zhao, T., Jin, Z., Du, W., Zhu, M.J., Chua, S.L. Gu, L. ^*, Ma, L.Z. ^* et al. (2015) PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix. Cell Research, 25, 1352-1367.

　　22.Wang, S., Liu, X., Liu, H., Zhang, L., Guo, Y., Yu, S., Wozniak, D.J. and Ma, L.Z. ^* (2015) The exopolysaccharide Psl-eDNA interaction enables the formation of a biofilm skeleton in Pseudomonas aeruginosa. Environmental Microbiology Reports, 7, 330-340.

　　23.Wang, D., Hildebrand, F., Ye, L., Wei, Q. and Ma, L.Z. ^* (2015) Genome Sequence of Mucoid Pseudomonas aeruginosa Strain FRD1. Genome Announcements, 3.

　　24.Wang, S., Yu, S., Zhang, Z., Wei, Q., Yan, L., Ai, G., Liu, H. and Ma, L.Z. ^* (2014) Coordination of swarming motility, biosurfactant synthesis, and biofilm matrix exopolysaccharide production in Pseudomonas aeruginosa. Applied and Environmental Microbiology, 80, 6724-6732.

　　25.Das, P., Yang, X.P. and Ma, L.Z. ^* (2014) Analysis of biosurfactants from industrially viable Pseudomonas strain isolated from crude oil suggests how rhamnolipids congeners affect emulsification property and antimicrobial activity. Frontiers in Microbiology, 5, 696.

　　26.Wei, Q. and Ma, L.Z. ^* (2013) Biofilm matrix and its regulation in Pseudomonas aeruginosa. International Journal of Molecular Sciences, 14, 20983-21005.

　　27.Wang, S., Parsek, M.R., Wozniak, D.J. and Ma, L.Z. ^* (2013) A spider web strategy of type IV pili-mediated migration to build a fibre-like Psl polysaccharide matrix in Pseudomonas aeruginosa biofilms. Environmental Microbiology, 15, 2238-2253.

　　28.Ma, L. ^*, Wang, S., Wang, D., Parsek, M.R. and Wozniak, D.J. (2012) The roles of biofilm matrix polysaccharide Psl in mucoid Pseudomonas aeruginosa biofilms. FEMS Immunology and Medical Microbiology, 65, 377-380.

　　29.Ma, L. ^*, Wang, J., Wang, S., Anderson, E.M., Lam, J.S., Parsek, M.R. and Wozniak, D.J. (2012) Synthesis of multiple Pseudomonas aeruginosa biofilm matrix exopolysaccharides is post-transcriptionally regulated. Environmental Microbiology, 14, 1995-2005.

　　30. Ma, L., Liu, X., Liang, H., Che, Y., Chen, C., Dai, H., Yu, K., Liu, M., Ma, L., Yang, C.H. Zhang L^* et al. (2012) Effects of 14-alpha-lipoyl andrographolide on quorum sensing in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 56, 6088-6094.

　　31.Starkey, M., Hickman, J.H., Ma, L., Zhang, N., De Long, S., Hinz, A., Palacios, S., Manoil, C., Kirisits, M.J., Starner, T.D. et al. (2009) Pseudomonas aeruginosa rugose small-colony variants have adaptations that likely promote persistence in the cystic fibrosis lung. Journal of Bacteriology, 191, 3492-3503.

　　32.Ma, L., Conover, M., Lu, H., Parsek, M.R., Bayles, K. and Wozniak, D.J. ^* (2009) Assembly and development of the Pseudomonas aeruginosa biofilm matrix. PLoS Pathogens, 5, e1000354.

　　33.Byrd, M.S., Sadovskaya, I., Vinogradov, E., Lu, H., Sprinkle, A.B., Richardson, S.H., Ma, L., Ralston, B., Parsek, M.R., Anderson, E.M. et al. (2009) Genetic and biochemical analyses of the Pseudomonas aeruginosa Psl exopolysaccharide reveal overlapping roles for polysaccharide synthesis enzymes in Psl and LPS production. Molecular Microbiology, 73, 622-638.

　　34.Huigens, R.W., 3rd, Ma, L., Gambino, C., Moeller, P.D., Basso, A., Cavanagh, J., Wozniak, D.J. and Melander, C. (2008) Control of bacterial biofilms with marine alkaloid derivatives. Molecular BioSystems, 4, 614-621.

　　35.Ma, L., Lu, H., Sprinkle, A., Parsek, M.R. and Wozniak, D.J. ^* (2007) Pseudomonas aeruginosa Psl is a galactose- and mannose-rich exopolysaccharide. Journal of Bacteriology, 189, 8353-8356.

　　36.Taghbalout, A., Ma, L. and Rothfield, L. ^* (2006) Role of MinD-membrane association in Min protein interactions. Journal of Bacteriology, 188, 2993-3001.

　　37.Ma, L., Jackson, K.D., Landry, R.M., Parsek, M.R. and Wozniak, D.J. ^* (2006) Analysis of Pseudomonas aeruginosa conditional psl variants reveals roles for the psl polysaccharide in adhesion and maintaining biofilm structure postattachment. Journal of Bacteriology, 188, 8213-8221.

　　38.Cui, Y., Tu, R., Guan, Y., Ma, L. and Chen, S^* (2006) Cloning, sequencing, and characterization of the Azospirillum brasilense fhuE gene. Current Microbiology, 52, 169-177.

　　39.Schimanski, B., Ma, L. and Gunzl, A. ^* (2004) Failure to detect binding of Trypanosoma brucei SNAPc to U2 and U6 snRNA gene sequences by in vitro transcription competition and pull-down assays. Molecular and Biochemical Parasitology, 137, 293-296.

　　40.Ma, L., King, G.F. and Rothfield, L. ^* (2004) Positioning of the MinE binding site on the MinD surface suggests a plausible mechanism for activation of the Escherichia coli MinD ATPase during division site selection. Molecular Microbiology, 54, 99-108.

　　41.Desnoues, N., Lin, M., Guo, X., Ma, L., Carreno-Lopez, R. and Elmerich, C^*. (2003) Nitrogen fixation genetics and regulation in a Pseudomonas stutzeri strain associated with rice. Microbiology (Reading, England), 149, 2251-2262.

　　42.Wang, J, Chen, S-F., Ma, L-Y., Li, J-L. ^* (2001)Cloning , sequencing and expression pattern, functional analysis of nifA in Azospirillum brasilense Yu62. Acta Microbiologia Sinica. 41:655-661(in Chinese ).

　　43.Ma, L-Y., Wu, Y. Wang, J., Zhao, Y-S., Li, J-L. ^* (1999)Site-directed mutagenesis analysis of draTG genes and their downstream region from Azospirillum brasilense Yu62. Chinese J. of Biotechnology 15:281-287 (in Chinese ).

　　44.Ma, L-Y. and Li, J-L. ^* (1997)Advance in genetics of Azospirillum and plant-root interactions (a review). High Technology letters 11:56-59. (in Chinese )

　　45.Ma, L-Y. and Li, J-L. ^* (1997) Sequencing and analysis of function of the upstream region of draTG genes from Azospirillum brasilense Yu62. Chinese J. of Biotechnology 13(4):343-349 (in Chinese and English).

　　46.Ma, L-Y. and Li, J-L. ^* (1997) Cloning and sequencing of draTG genes and downstream region from Azospirillum brasilense Yu62. Chinese J. of Biotechnology 13(3):227-235 (in Chinese and English).

　　47.Yan, D-L., He, L-H., Ma, L-Y., Li, J-L. ^* (1995)Effect of Klebsiella pneumoniae nifA on the regulation of nif gene expression by ammonia in Azospirillum brasilense. Chinese J. of Biotechnology 11(4):385-388. (in Chinese )

　　48.Yan, D-L., He, L-H., Ma, L-Y., Li, J-L. ^* (1995)Transcriptional activation of Azospirillum brasilense nifH promoter by NifA of Klebsiella pneumoniae. Chinese J. of Biotechnology 11(3):205-210. (in Chinese)

　　49.Ma, L-Y., Yan, D-L., He, L-H., Li, J-L. ^* (1994)Insertion mutagensis used in nitrogen-fixing bacteria (a review). Microbiology 21:101-105 . (in Chinese )

　　50.Nan, Q-X., Ren, F-ZH., Yang, Z-B., Zhang, X-J., Ma, L-Y. (1992) Studies on the forming process of milk fan in Yun nan province. Chinese J. of Animal Science 28(2):25-27.

　　申请专利

　　1.MA, Lvyan, YU, Shan, WU, Huijun, WANG, Shiwei, Wang, Di, Reagent and methods for inhibiting or disrupting biofilm. Patent No.: US10499655B2. (2019.12.10)

　　2.马旅雁，王世伟，王迪，杨新平。高效抑菌鼠李糖脂高产菌株及其应用。授权号：CN103232957A。

　　3.马旅雁，王世伟，王迪，杨新平。一株适用于油藏环境的假单胞菌及其应用。授权号: CN103215207A。

　　4.马旅雁、刘茜、王世伟。导电四型菌毛及其编码基因和含有该基因的载体和相应的生产菌株及其应用。申请号：201810555794.6

　　5.马旅雁、王迪、张妙坤、赵天湖、王世伟PslG蛋白或其编码序列在检测微生物数量方面的应用和方法。申请号：201810154326.8

　　6.马旅雁、王迪、王世伟、徐安明。一种促进固氮细菌形成胞囊结构的方法及其专用培养基。申请号：201710034031.2。

　　7.马旅雁、谷立川、于珊、吴慧君、王世伟、苏甜甜、王迪、杨亮。用于抑制/瓦解生物被膜的抑制剂及其应用。申请号：PCT/CN2016/076171。

　　8.马旅雁、谷立川、于珊、吴慧君、王世伟、苏甜甜、王迪、杨亮。用于抑制/瓦解生物被膜的抑制剂及其应用。申请号： 201510112746.6。

　　9.马旅雁，王世伟。提高鼠李糖脂产量的方法及其专用铜绿假单胞菌。申请号： 201410328471。

　　参编专著

　　1.马旅雁,王世伟,张真印,杨霁舟.（2012）生物膜形成的机制.《微生物生物膜与感染》周学东施文元主编人民卫生出版社p1-34.

　　2.Ma, L-Y. and Li, J-L. * (1998) Advance in genetics researches of nitrogen fixation (a review). In Engineering of Agriculural Biology. Man, K-Q., Chen, S-Y., Li, J-L., Zhu, Y-D.(eds.). Chemical Industry Publisher. p15-48. (in Chinese )