代表性成果-- 微生物资源前期开发国家重点实验室

EN

李德峰课题组

代表性成果

代表性图片

c-di-GMP调控YcgR介导的鞭毛刹车机制研究

近期代表性论文（* 通讯作者）

Hou YJ, Yang WS, Hong Y, Zhang Y, Wang DC*, Li DF*. Structural insights into the mechanism of c-di-GMP-bound YcgR regulating flagellar motility in Escherichia coli. J Biol Chem. 2020 Jan 17;295(3):808-821.
Hong Y#, Huang Z#, Guo L, Ni B, Jiang CY, Li XJ, Hou YJ, Yang WS, Wang DC, Zhulin IB, Liu SJ*, Li DF*. The ligand-binding domain of a chemoreceptor from Comamonas testosteroni has a previously unknown homotrimeric structure. Mol Microbiol. 2019 Sep;112(3):906-917.
Zhao F, Hou YJ, Zhang Y, Wang DC*, Li DF*. The 1-β-methyl group confers a lower affinity of l,d-transpeptidase Ldt_Mt2 for ertapenem than for imipenem. Biochem Biophys Res Commun. 2019 Mar 5;510(2):254-260.
Yang WS, Hong Y, Zhang Y, Wang DC*, Li DF*, Hou YJ*. A potential substrate binding pocket of BdcA plays a critical role in NADPH recognition and biofilm dispersal. Biochem Biophys Res Commun. 2018 Mar 11;497(3):863-868.
Feng N#, Qi C#, Hou YJ, Zhang Y, Wang DC*, Li DF*. The C2'- and C3'-endo equilibrium for AMP molecules bound in the cystathionine-beta-synthase domain. Biochem Biophys Res Commun. 2018 Mar 4;497(2):646-651.
Gao YR^#, Li DF^#, Fleming J^#, Zhou YF, Liu Y, Deng JY, Zhou L, Zhou J, Zhu GF, Zhang XE, Wang DC*, Bi LJ*. Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis. Sci Rep. 2017 Jul 25;7(1):6471.
Zheng X^#, Feng N^#, Li D*, Dong X*, Li J*. New molecular insights into an archaeal RNase J reveal a conserved processive exoribonucleolysis mechanism of the RNase J family. Mol Microbiol. 2017 Nov;106(3):351-366.
Yang K^#, Li DF^#, Wang X, Liang J, Sitia R, Wang CC*, Wang X*. Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention. Structure. 2016 Oct 4;24(10):1755-1765.
Miao LL^#, Hou YJ^#, Fan HX, Qu J, Qi C, Liu Y, Li DF*, Liu ZP*. Molecular Structural Basis for the Cold Adaptedness of the Psychrophilic β-Glucosidase BglU in Micrococcus antarcticus. Appl Environ Microbiol. 2016 Jan 22;82(7):2021-30.
Qi C^#, Li DF^#, Feng L, Hou Y, Sun H, Wang DC*, Liu W*. Biochemical and structural characterization of a novel ubiquitin-conjugating enzyme E2 from Agrocybe aegeria reveals Ube2w family-specific properties. Sci Rep. 2015 Nov 3;5:16056.
Zhang XL^#, Li DF^#, Fleming J, Wang LW, Zhou Y, Wang DC, Zhang XE*, Bi LJ*. Core component EccB1 of the Mycobacterium tuberculosis type VII secretion system is a periplasmic ATPase. FASEB J. 2015 Dec;29(12):4804-14.
Fan S^#, Li DF^#, Wang DC, Fleming J, Zhang H, Zhou Y, Zhou L, Zhou J, Chen T, Chen G*, Zhang XE*, Bi L*. Structure and function of Mycobacterium smegmatis 7-keto-8-aminopelargonic acid (KAPA) synthase. Int J Biochem Cell Biol. 2015 Jan;58:71-80.
Li WJ^#, Li DF^#, Hu YL, Zhang XE, Bi LJ*, Wang DC*. Crystal structure of L,D-transpeptidase Ldt_Mt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis. Cell Res. 2013 May;23(5):728-31.
Li DF^#, Zhang JY^#, Hou YJ, Liu L, Hu Y, Liu SJ*, Wang DC*, Liu W*. Structures of aminophenol dioxygenase in complex with intermediate, product and inhibitor. Acta Crystallogr D Biol Crystallogr. 2013 Jan;69(Pt 1):32-43.
Zhang X^#, Zhang J, Zhang R, Guo Y, Wu C, Mao X, Guo G, Zhang Y, Li D*, Zou Q*. Structural, enzymatic and biochemical studies on Helicobacter pylori arginase. Int J Biochem Cell Biol. 2013 May;45(5):995-1002.
Zhang J^#, Zhang X, Zhang R, Wu C, Guo Y, Mao X, Guo G, Zhang Y, Wang DC, Li D*, Zou Q*. Modeling studies with Helicobacter pylori octaprenyl pyrophosphate synthase reveal the enzymatic mechanism of trans-prenyltransferases. Int J Biochem Cell Biol. 2012 Dec;44(12):2116-23.
Bian CF^#, Zhang Y, Sun H, Li DF*, Wang DC*. Structural basis for distinct binding properties of the human galectins to Thomsen-Friedenreich antigen. PLoS One. 2011;6(9):e25007.
Li DF^#, Zhang N^#, Hou YJ, Huang Y, Hu Y, Zhang Y, Liu SJ*, Wang DC*. Crystal structures of the transcriptional repressor RolR reveals a novel recognition mechanism between inducer and regulator. PLoS One. 2011 May 3;6(5):e19529.
Zhang J^#, Zhang X, Wu C, Lu D, Guo G, Mao X, Zhang Y, Wang DC, Li D*, Zou Q*. Expression, purification and characterization of arginase from Helicobacter pylori in its apo form. PLoS One. 2011;6(10):e26205.
Feng L, Sun H, Zhang Y, Li DF* & Wang DC*. Structural insights into the recognition mechanism between an antitumor galectin AAL and the Thomsen-Friedenreich antigen. FASEB J. 2010 Oct;24(10):3861-8.
Yang N^#, Li DF^#, Feng L, Xiang Y, Liu W*, Sun H*, Wang DC*. Structural basis for the tumor cell apoptosis-inducing activity of an antitumor lectin from the edible mushroom Agrocybe aegerita. J Mol Biol. 2009 Apr 3;387(3):694-705.