代表性图片

图1 微黄白链霉菌种群系统学与Structure分析

图2 链霉菌和小单孢菌的菌落及电镜形态

图3 红壤放线菌的部分活性代谢产物

图4 Azolemycin生物合成途径解析

图5 模拟微重力及空间飞行促进链霉菌发育分化

代表性论文（#共同第一作者; *通讯作者）：

1.     Wang J, Li Y, Pinto-Tomás AA, Cheng K, Huang Y^*. 2022. Habitat adaptation drives speciation of a Streptomyces species with distinct habitats and disparate geographic origins. mBio. https://doi.org/10.1128/mBio.02781-21

2.     Li Y, Huang Y^*. 2022. Distribution and evolutionary history of sialic acid catabolism in the phylum Actinobacteria. Microbiol Spectr. https://doi.org/10.1128/Spectrum.02380-21

3.     Yan B, Liu N, Liu M, Du X, Shang F, Huang Y^*. 2021. Soil actinobacteria tend to have neutral interactions with other co-occurring microorganisms, especially under oligotrophic conditions. Environ Microbiol, 23(8): 4126–4140. https://doi.org/10.1111/1462-2920.15483

4.     Zhang L, Chen Y, Xia Q, Kemner KM, Shen Y, O'Loughlin EJ, Pan Z, Wang Q, Huang Y, Dong H^*, Boyanov MI^*. 2021. Combined effects of Fe(III)-bearing clay minerals and organic ligands on U(VI) bioreduction and U(IV) speciation. Environ Sci Technol, 55(9):5929-5938. https://doi.org/10.1021/acs.est.0c08645

5.     Yan B, Guo X, Liu M, Huang Y^*. 2020. Ktedonosporobacter rubrisoli gen. nov., sp. nov., a novel representative of the class Ktedonobacteria, isolated from red soil, and proposal of Ktedonosporobacteraceae fam. nov. Int J Syst Evol Microbiol, 70:1015-1025. https://doi.org/10.1099/ijsem.0.003864

6.     Zhang L, Zeng Q, Liu X, Chen P, Guo X, Ma LZ, Dong H^*, Huang Y^*. 2019. Iron reduction by diverse actinobacteria under oxic and pH-neutral conditions and the formation of secondary minerals. Chem Geol, 525: 390-399. https://doi.org/10.1016/j.chemgeo.2019.07.038

7.     Li Y, Pinto-Tomás AA, Rong X, Cheng K, Liu M, Huang Y^*. 2019. Population genomics insights into adaptive evolution and ecological differentiation in streptomycetes. Appl Environ Microbiol, 85: e02555-18. https://doi.org/10.1128/AEM.02555-18

8.     Song F, Liu N, Liu M, Chen Y, Huang Y^*. 2018. Identification and characterization of mycemycin biosynthetic gene clusters in Streptomyces olivaceus FXJ8.012 and Streptomyces sp. FXJ1.235. Mar Drugs, 16: 98.

9.     Zhang L, Dong H^*, Liu Y, Bian L, Wang X, Zhou Z, Huang Y^*. 2018. Bioleaching of rare earth elements from bastnaesite-bearing rock by actinobacteria. Chem Geol, 483: 544-557. https://doi.org/10.1016/j.chemgeo.2018.03.023

10.   Zhang L, Xi L, Ruan J, Huang Y^*. 2017. Kocuria oceani sp. nov, isolated from a deep-sea hydrothermal plume. Int J Syst Evol Microbiol, 67: 164-169.

11.   Chen P, Zhang L, Guo X, Dai X, Liu L, Xi L, Wang J, Song L, Wang Y, Zhu Y, Huang L, Huang Y^*. 2016. Diversity, biogeography, and biodegradation potential of actinobacteria in the deep-sea sediments along the Southwest Indian Ridge. Front Microbiol, 7: 1340. https://doi.org/10.3389/fmicb.2016.01340

12.   Cheng K, Rong X^*, Huang Y^*. 2016. Widespread interspecies homologous recombination reveals reticulate evolution within the genus Streptomyces. Mol Phylogenet Evol, 102: 246-254. http://dx.doi.org/10.1016/j.ympev.2016.06.004

13.   Liu N^#, Song L^#, Liu M^#, Shang F, Anderson Z, Fox DJ, Challis GL^*, Huang Y^*. 2016. Unique post-translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264. Chem Sci, 7(1): 482-488. https://doi.org/10.1039/c5sc03021h

14.   Liu M^#, Liu N^#, Shang F, Huang Y^*. 2016. Activation and identification of NC-1, a cryptic cyclodepsipeptide from red soil-derived Streptomyces sp. FXJ1.172. Eur J Org Chem, 23: 3943-3948. https://doi.org/10.1002/ejoc.201600297.

15.   Liu N^#, Song F^#, Shang F, Huang Y^*. 2015. Mycemycins A-E, new dibenzoxazepinones isolated from two different streptomycetes. Mar Drugs, 13(10): 6247-6258. https://doi.org/10.3390/md13106247

16.   Huang B, Liu N, Rong X, Ruan J, Huang Y^*. 2015. Effects of simulated microgravity and spaceflight on morphological differentiation and secondary metabolism of Streptomyces coelicolor A3(2). Appl Microbiol Biotechnol, 99(10): 4409-4422. https://doi.org/10.1007/s00253-015-6386-7

17.   Guo X^#, Liu N^#, Li X, Ding Y, Shang F, Gao Y, Ruan J, Huang Y^*. 2015. Red soils harbour diverse culturable actinomycetes that are promising sources of novel secondary metabolites. Appl Environ Microbiol, 81: 3086-3103. https://doi.org/10.1128/AEM.03859-14

18.   Cheng K^#, Rong X^#, Pinto-Tomás A, Fernández-Villalobos M, Murillo-Cruz C, Huang Y^*. 2015. Population genetic analysis of Streptomyces albidoflavus reveals habitat barriers to homologous recombination in the diversification of streptomycetes. Appl Environ Microbiol, 81: 966-975. https://doi.org/10.1128/AEM.02925-14

19.   Rong X, Doroghazi JR, Cheng K, Zhang L. Buckley DH, Huang Y^*. 2013. Classification of Streptomyces phylogroup pratensis (Doroghazi and Buckley, 2010) based on genetic and phenotypic evidence, and proposal of Streptomyces pratensis sp. nov. Syst Appl Microbiol, 36: 401-407.

20.   Liu N, Shang F, Xi L, Huang Y^*. 2013. Tetroazolemycins A and B, two new oxazole-thiazole siderophores from deep-sea Streptomyces olivaceus FXJ8.012. Mar Drugs, 11: 1524-1533.

21.   Rong X, Huang Y^*. 2012. Taxonomic evaluation of the Streptomyces hygroscopicus clade using multilocus sequence analysis and DNA-DNA hybridization, validating the MLSA scheme for systematics of the whole genus. Syst Appl Microbiol, 35:7-18.

22.   Wang H^#, Liu N^#, Xi L, Rong X. Ruan J, Huang Y^*. 2011. Genetic screening strategy for rapid access to polyether ionophore producers and products in actinomycetes. Appl Environ Microbiol, 77: 3433-3442.

23.   Rong X, Liu N, Ruan J, Huang Y^*. 2010. Multilocus sequence analysis of Streptomyces griseus isolates delineating intraspecific diversity in terms of both taxonomy and biosynthetic potential. Antonie van Leeuwenhoek, 98: 237-248.

24.   Rong X, Huang Y^*. 2010. Taxonomic evaluation of the Streptomyces griseus clade using multilocus sequence analysis and DNA-DNA hybridization, with proposal to combine 29 species and three subspecies as 11 genomic species. Int J Syst Evol Microbiol, 60: 696-703.

25.   Gao P, Huang Y^*. 2009. Detection, distribution, and organohalogen compound discovery implications of the reduced flavin adenine dinucleotide-dependent halogenase gene in major filamentous actinomycete taxonomic groups. Appl Environ Microbiol, 75: 4813-4820. 

26.   Rong X, Guo Y, Huang Y.^* 2009. Proposal to reclassify the Streptomyces albidoflavus clade on the basis of multilocus sequence analysis and DNA-DNA hybridization, and taxonomic elucidation of Streptomyces griseus subsp. solvifaciens. Syst Appl Microbiol, 32: 314-322.

27.   Qiu D, Ruan J, Huang Y.^* 2008. Selective isolation and rapid identification of members of the genus Micromonospora. Appl Environ Microbiol, 74: 5593-5597.                                             

28.   Guo Y, Zheng W, Rong X, Huang Y.^* 2008. A multilocus phylogeny of Streptomyces griseus 16S rRNA gene clade: use of multilocus sequence analysis for streptomycete systematics. Int J Syst Evol Microbiol, 58: 149-159.  

(Bai, Zhang et al. 2023, Huang, Chen et al. 2023, Liu, Wang et al. 2023, Du, Liu et al. 2024, Lu, Liu et al. 2024, Wang, Liu et al. 2024)

1. Bai, B., L. Zhang, H. Dong and Y. Huang (2023). "Coupled Fe(III) reduction and phenanthrene degradation by marine-derived Kocuria oceani FXJ8.057 under aerobic condition." J Hazard Mater 459: 132237.

2. Liu, M., K. Wang, J. Wei, N. Liu, G. Niu, H. Tan and Y. Huang (2023). "Comparative and Functional Analyses Reveal Conserved and Variable Regulatory Systems That Control Lasalocid Biosynthesis in Different Streptomyces Species." Microbiol Spectr 11(2): e0385222.

3. Du, X., N. Liu, B. Yan, Y. Li, M. Liu and Y. Huang (2024). "Proximity-based defensive mutualism between Streptomyces and Mesorhizobium by sharing and sequestering iron." ISME J 18(1).

4. Huang, J., P. Chen, Y. X. Zhu, J. Wang, L. Song, X. Q. Han and Y. Huang (2023). "Biogeography and potential ecological functions of prokaryotes in the hydrothermal and non-hydrothermal field sediments of the Indian Ocean Ridges." Frontiers in Marine Science 9.

5. Lu, L., N. Liu, Z. Fan, M. Liu, X. Zhang, J. Tian, Y. Yu, H. Lin, Y. Huang and Z. Kong (2024). "A novel PGPR strain, Streptomyces lasalocidi JCM 3373(T), alleviates salt stress and shapes root architecture in soybean by secreting indole-3-carboxaldehyde." Plant Cell Environ 47(6): 1941-1956.

6. Wang, K., N. Liu, M. Liu, P. Zhao, N. Zhong, G. L. Challis and Y. Huang (2024). "Discovery and Biosynthesis of Streptolateritic Acids A-D: Acyclic Pentacarboxylic Acids from Streptomyces sp. FXJ1.172 with Promising Activity against Potato Common Scab." J Agric Food Chem 72(26): 14760-14768.

7. Huang, J., X. Zheng, T. Yu, M. Ali, J. Wiese, S. Hu, L. Huang and Y. Huang (2025). "Diverse lifestyles and adaptive evolution of uncultured UBA5794 actinobacteria, a sister order of “Candidatus actinomarinales”." Environmental Microbiome 20(1): 39.

1. 黄英, 张利敏, 郗丽君, 宋磊. 一株深海放线菌及其应用. 授权号：XL201410534724.4, 授权日期: 2017.06.09 

2. 黄英, 刘宁, 郗丽君, 张利敏. 一株海洋链霉菌及其应用. 授权号：ZL201110140088.3, 授权日期: 2012.12.19 

3. 黄英, 刘宁, 郗丽君, 张利敏. 海洋链霉菌产生的化合物及其应用. 授权号：ZL201110174314X, 授权日期: 2013.03.20