代表性图片

　　近期代表性论文（* 通讯作者）

　　Zhang Z#, Zhao M#, Wang L, Chen Y, Dong Y, Gong Y*, Huang L*. 2017. Roles of Leu28 side chain intercalation in the interaction between Cren7 and DNA. The Biochemical journal 474:1727-1739.

　　Sun F, Huang L*. 2016. A euryarchaeal histone modulates strand displacement synthesis by replicative DNA polymerases. ScienceChinaLife sciences 59:709-716.

　　Dai X, Wang H, Zhang Z, Li K, Zhang X, Mora-Lopez M, Jiang C, Liu C, Wang L, Zhu Y, Hernandez-Ascencio W, Dong Z, Huang L*. 2016. Genome Sequencing of Sulfolobus sp. A20 fromCosta Ricaand Comparative Analyses of the Putative Pathways of Carbon, Nitrogen, and Sulfur Metabolism in Various Sulfolobus Strains. Frontiers in microbiology 7:1902.

　　Chu Y#, Zhu Y#, Chen Y, Li W, Zhang Z, Liu D, Wang T, Ma J, Deng H, Liu Z-J, Ouyang S*, Huang L*. 2016. aKMT Catalyzes Extensive Protein Lysine Methylation in the Hyperthermophilic Archaeon Sulfolobus islandicusbut is Dispensable for the Growth of the Organism. Molecular & cellular proteomics 15:2908-2923.

　　Zheng X, Liu H, Song L, Zhang L, Wang H, Dai X, Huang L*. 2015. Phaeocystidibacter marisrubri sp. nov., a member of the family Cryomorphaceae isolated fromRed Seasediment. International journal of systematic and evolutionary microbiology 65:2199-2203.

　　Zhang Z, Gong Y, Chen Y, Li H, Huang L*. 2015. Insights into the interaction between Cren7 and DNA: the role of loop beta3-beta4. Extremophiles 19:395-406.

　　Zhan Z, Zhou J, Huang L*. 2015. Site-Specific Recombination by SSV2 Integrase: Substrate Requirement and Domain Functions. Journal of virology 89:10934-10944.

　　Xiang X#, Huang X#, Wang H#, Huang L*. 2015. pTC Plasmids from Sulfolobus Species in the Geothermal Area ofTengchong,China: Genomic Conservation and Naturally-Occurring Variations as a Result of Transposition byMobileGenetic Elements. Life (Basel,Switzerland) 5:506-520.

　　Wang H, Peng N, Shah SA, Huang L*, She Q*. 2015. Archaeal extrachromosomal genetic elements.Microbiology and molecular biology reviews 79:117-152.

　　Liu B#, Ouyang S#, Makarova KS, Xia Q, Zhu Y, Li Z, Guo L, Koonin EV, Liu Z-J*, Huang L*. 2015. A primase subunit essential for efficient primer synthesis by an archaeal eukaryotic-type primase. Nature communications 6:7300.

　　Lang S, Huang L*. 2015. The Sulfolobus solfataricus GINS Complex Stimulates DNA Binding and Processive DNA Unwinding by Minichromosome Maintenance Helicase. Journal of bacteriology 197:3409-3420.

　　Dai X#, Tian Y#, Li J#, Luo Y, Liu D, Zheng H, Wang J, Dong Z, Hu S*, Huang L*. 2015. Metatranscriptomic analyses of plant cell wall polysaccharide degradation by microorganisms in the cow rumen. Applied and environmental microbiology 81:1375-1386.

　　Xing X, Zhang L, Guo L, She Q, Huang L*. 2014. Sulfolobus replication factor C stimulates the activity of DNA polymerase B1. Journal of bacteriology 196:2367-2375.

　　Song L#, Wang H#, Wang S, Zhang H, Cong H, Huang L*, Tien P*. 2014. Self-assembled bionanoparticles based on the Sulfolobus tengchongensis spindle-shaped virus 1 (STSV1) coat protein as a prospective bioscaffold for nanotechnological applications. Extremophiles 18:745-754.

　　Guo L#, Ding J#, Guo R, Hou Y, Wang D-C*, Huang L*. 2014. Biochemical and structural insights into RNA binding by Ssh10b, a member of the highly conserved Sac10b protein family in Archaea. The Journal of biological chemistry 289:1478-1490.

　　Erdmann S, Chen B, Huang X, Deng L, Liu C, Shah SA, Le Moine Bauer S, Sobrino CL, Wang H, Wei Y, She Q, Garrett RA, Huang L*, Lin L*. 2014. A novel single-tailed fusiform Sulfolobus virus STSV2 infecting modelSulfolobus species. Extremophiles 18:51-60.

　　Sun F, Huang L*. 2013. Sulfolobus chromatin proteins modulate strand displacement by DNA polymerase B1.Nucleic acids research 41:8182-8195.

　　Ren Y, She Q, Huang L*. 2013. Transcriptomic analysis of the SSV2 infection of Sulfolobus solfataricus with and without the integrative plasmid pSSVi. Virology 441:126-134.

　　Zhang Z, Guo L, Huang L*. 2012. Archaeal chromatin proteins. Science China-Life Science. 55(5):377-85.

　　Zhan Z#, Ouyang S#, Liang W, Zhang Z, Liu Z*, Huang L*. 2012. Structural and functional characterization of the C-terminal catalytic domain of SSV1 integrase. Acta Crystallographica Section D-Biological Crystallography. 68(Pt 6): 659-70.

　　ChuY, Zhang Z, Wang Q, Luo Y, Huang L*. 2012. Identification and characterization of a highly conserved crenarchaeal protein lysine methyltransferase with broad substrate specificity. Journal of bacteriology. 194(24): 6917-26.

　　Dai X#, Zhu Y#, Luo Y#, Song L, Liu D, Liu L, Chen F, Wang M, Li J, Zheng X, Dong Z, Hu S, Li L, Xu J*, Huang L*, Dong X*. 2012. Metagenomic Insights into the Fibrolytic Microbiome in Yak Rumen. PLoS ONE 7(7): e40430. doi:10.1371/journal.pone.0040430.

　　Hu J, Guo L, Wu K, Liu B, Lang S, Huang L*. 2012. Template-dependent polymerization across discontinuous templates by the heterodimeric primase from the hyperthermophilic archaeonSulfolobus solfataricus. Nucleic acids research 40:3470-3483.

　　Guo L#, Brügger K#, Liu C#, Shah SA#, Zheng H, Zhu Y, Wang S, Lillest？l RK, Chen L, Frank J, Prangishvili D, Paulin L, She Q,  Huang L*, Garrett RA*. 2011. Genome analyses of Icelandic strains of Sulfolobus islandicus, model organisms for genetic and virus-host interaction studies. Journal of bacteriology 193(7):1672-80.

　　Li X, Guo L, Deng L, Feng D, Ren Y, Chu Y, She Q *, Huang L*. 2011. Deletion of the topoisomerase III gene in the hyperthermophilic archaeon Sulfolobus islandicus results in slow growth and defects in cell cycle control. Journal of genetics and genomics 38(6):253-9.

　　Zhang Z #, Gong Y #, Guo L, Jiang T*, Huang L*. 2010. Structural insights into the interaction of the crenarchaeal chromatin protein Cren7 with DNA. Molecular Microbiology 76: 749–759.

　　Guo X, Huang L*. 2010. An SF3 DNA helicase encoded by plasmid pSSVi from the hyperthermophilic Archaeon Sulfolobus solfataricus unwinds DNA as a higher-order oligomer and interacts with host primase. Journal of bacteriology 192(7):1853-64.

　　Zhang L, Lou H, Guo L, Zhan Z, Duan Z, Guo X, Huang L*. 2010. Accurate DNA synthesis by Sulfolobus solfataricus DNA polymerase B1 at high temperature. Extremophiles 14(1):107-17.

　　Guo L#, Feng Y#, Zhang Z,YaoH, Luo Y, Wang J*, Huang L*. 2008. Biochemical and structural characterization of Cren7, a novel chromatin protein conserved among Crenarchaea. Nucleic Acids Research 36:( 4 )1129-1137

　　Wang Y, Duan Z, Zhu H, Guo X, Wang Z, Zhou J, She Q, Huang L*. 2007. A novel Sulfolobus non-conjugative extrachromosomal genetic element capable of integration into the host genome and spreading in the presence of a fusellovirus. Virology 363: 124-33.

　　Wu K, Lai X, Guo X, Hu J, Xiang X, Huang L*. 2007. Interplay between primase and replication factor C in the hyperthermophilic archaeon Sulfolobus solfataricus. Molecular microbiology 63(3):826–837.

　　# shared the first author; * corresponding author.