代表性成果

代表性论文(#共同一作,*通讯作者)

1. Yao Shigang#, Wu Xinyi#, Li Y, Song Y, Wang C, Zhang Gang*, Feng Jie*. Harnessing the native type I-F CRISPR-Cas system of Acinetobacter baumannii for genome editing and gene repression. Int J Antimicrob Agents. 2023 Sep 4;62(5):106962.

2. Zeng Yuan#, Song Yuqin#, Cui Lanqing#, Wu Q, Wang C, Coelho AC, Zhang G, Wei D, Li C, Zhang J, Corbeil J, Li Yun*, Feng Jie*. Phylogenomic insights into evolutionary trajectories of multidrug resistant S. pneumoniae CC271 over a period of 14 years in China. Genome Med. 2023 Jul 4;15(1):46.

3. Zhang Gang#, Yao Shigang#, Liu Yunan, Fang Hailing, Song Yuqin, Wang,Chao Wei Dawei, Feng Jie *. Systematic discovery of a new catalogue of tyrosine-type integrases in bacterial genomic islands. Appl Environ Microbiol. 2023 Feb 28;89(2):e0173822.

4. Yao Shigang, Wei Dawei, Tang Na, Song Yuqin, Wang Chao, Feng Jie*, Zhang Gang*. Efficient suppression of natural plasmid-borne gene expression in carbapenem-resistant Klebsiella pneumoniae using a compact CRISPR interference system. Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0089022.

5. Yang Jing#, Li Yi#, Tang Na#, Li J#, Zhou J, Lu S, Zhang G, Song Y, Wang C, Zhong J, Xu J*, Feng Jie*. The human gut serves as a reservoir of hypervirulent Klebsiella pneumoniae. Gut Microbes. 2022 Jan-Dec;14(1):2114739.

6. Wei Dawei#, Wong N#, Song Y, Zhang G, Wang C, Li J, Feng Jie*. IS26 veers genomic plasticity and genetic rearrangement toward carbapenem hyperresistance under sublethal antibiotics. mBio. 2022 Feb 8;13(1):e0334021.

7. Tang Na#, Hu J#, Zhao Y, Song Y, Wang C, Zhang G, Wei D, Fang H, Li C, Jia R, Feng Jie*. In vivo evolution of carbapenem resistance in hypervirulent Klebsiella pneumoniae in a patient undergoing long-term treatment. J Antimicrob Chemother. 2022 Feb 2;77(2):531-533.

8. Zhang Gang#, Li Jianjuan#, Ai Guomin, He Jialiang, Wang Chao*, Feng Jie*. A new intrinsic aminoglycoside 6'-N-acetyltransferase subclass, AAC(6')-III, in Burkholderia pseudomallei, Burkholderia mallei, and Burkholderia oklahomensis. J Antimicrob Chemother. 2020 May 1;75(5):1352-1353.

9. Zhang Chaodong#, Ju Yingjiao#, Tang Na#, Li Yun, Zhang Gang, Song Yuqin, Fang Hailing, Yang Liang*, Feng Jie*. Systematic analysis of supervised machine learning as an effective approach to predicate -lactam resistance phenotype in Streptococcus pneumoniae. Brief Bioinform. 2020 Jul 15;21(4):1347-1355.

10. Zhang Gang, Sun Kaiwen, Ai Guomin, Li Jianjuan, Tang Na, Wang Chao*, Feng Jie*. A novel family of intrinsic chloramphenicol acetyltransferase CATC in Vibrio parahaemolyticus: naturally occurring variants reveal diverse resistance levels against chloramphenicol. Inter J Antimicrob Agents. 2019 Mar 13. pii: S0924-8579(19)30065-2. 

11. Du Xiaochen#, Bayliss Sion C#, Feil Edward J, Liu Ying, Wang Chao, Zhang Gang, Zhou Dongsheng, Wei Dawei, Tang Na, Leclercq S bastien O, Feng Jie*. Real time monitoring of Aeromonas salmonicida evolution in response to successive antibiotic therapies in a commercial fish farm. Environ Microbiol. 2019 Jan 13. doi: 10.1111/1462-2920.14531. 

12. Tian Jingjing#, Zhang Gang#, Ju Y, Tang Na, Li Jianjuan, Jia Rufu, Feng Jie*. Five novel carbapenem-hydrolysing OXA-type -lactamase groups are intrinsic in Acinetobacter spp. J Antimicrob Chemother. 2018, 73(12):3279-3284. 

13. Zhang Gang, Leclercq Sebastien Olivier, Tian Jingjing, Wang Chao, Yahara Koji, Ai Guomin, Liu Shuangjiang, Feng Jie*. A new subclass of intrinsic aminoglycoside nucleotidyltransferases, ANT(3")-II, is horizontally transferred among Acinetobacter spp. by homologous recombination. PLoS Genet. 2017 Feb 2; 13(2): e1006602.

14. Leclercq SO#, Wang C#, Sui Z, Wu H, Zhu B, Deng Y, Feng Jie*. A multiplayer game: species of Clostridium, Acinetobacter, and Pseudomonas are responsible for the persistence of antibiotic resistance genes in manure-treated soils. Environ Microbiol. 2016 Oct;18(10):3494-3508.

15. Zhang Gang, Tian Jingjing, Wang Chao, Chen Jifeng, Feng Jie*. Identification of novel cryptic aminoglycoside phosphotransferases in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2016, 60(11):6983-6985.

16. Zhang Gang, Wang Chao, Sui Zhihai, Feng Jie*. Insights into the evolutionary trajectories of fluoroquinolone resistance in Streptococcus pneumoniae. J Antimicrob Chemother. 2015, 70(9): 2499-2506.

17. Wang Chao#, Sui Zhihai#, S bastien Olivier Leclercq, Zhang Gang, Zhao Meilin, Chen Weiqi, Feng Jie*.Functional characterization and phylogenetic analysis of acquired and intrinsic macrolide phosphotransferases in the Bacillus cereus group. Environ Microbiol. 2015, 17(5): 1560-1573.

18. Zhou Wenqing, Yao Kaihu, Zhang Gang, Yang Yonghong, Li Yun, Lv Yuan, Feng Jie*.  Mechanism for transfer of transposon Tn2010 carrying macrolide resistance genes in Streptococcus pneumoniae and its effects on genome evolution. J Antimicrob Chemother. 2014, 69(6): 1470-1473.

19. Yang Jing#, Wang Chao#, Wu Jinyu, Liu Li, Zhang Gang, Feng Jie*. Characterization of a multiresistant mosaic plasmid from a fish farm sediment Exiguobacterium sp. isolate reveals aggregation of functional clinic-associated antibiotic resistance genes. Appl Environ Microb. 2014, 80(4): 1482-1488. 

20. Zhang Gang#, TianWenyu#, Wang Chao, Feng Jie*. Identification of a novel resistance mutation in parE that confers high-level resistance to moxifloxacin in Streptococcus pneumoniae. J Antimicrob Chemother. 2012, 67(11): 2773-2774.


研究中代表性图片

中国CC271克隆群的贝叶斯系统发育分析及主要群体演化历史示意图

Genome Med. 2023 Jul 4;15(1):46


健康人肠道可携带高毒力肺炎克雷伯菌

Gut Microbes. 2022 Jan-Dec;14(1):2114739


接触亚致死抗生素后菌株通过基因扩增迅速增加碳青霉烯耐药性

 

mBio. 2022 Feb 8;13(1):e0334021.


机器学习预测实验菌株的耐药水平

 

Brief Bioinform. 2020 Jul 15;21(4):1347-1355.


ant(3")-IIa基因的同源重组分析

 

PLoS Genet. 2017 Feb 2; 13(2): e1006602