代表性成果

  1.Lei Qi, Lei Yue, Deqin Feng, Fengxia Qi, Jie Li*, and Xiuzhu Dong*.  Genome-wide mRNA processing in methanogenic archaea reveals post-transcriptional regulation of ribosomal protein synthesis, Nucleic Acids Res. 2017, 45(12):7285-7298. 

  2.Xin Zheng#, Na Feng#, Defeng Li*, Xiuzhu Dong* and Jie Li #*. New molecular insights into an archaeal RNase J reveal a conserved processive exoribonucleolysis mechanism of the RNase J family, Mol Microbiol, 2017, 106(3):351-366.  

  3.Bo Zhang, Lei Yue, Liguang Zhou, Lei Qi, Jie Li*, Xiuzhu Dong*. The conserved TRAM domain functions as the archaeal cold shock protein via RNA chaperone activity, Front Microbiol. 2017, 8:1597. 

  4.Jie Li#,*, Bo Zhang#, Liguang Zhou#, Lei Qi , Lei Yue, Wenting Zhang, Huicai Cheng, William B Whitman*, Xiuzhu Dong*. The archaeal RNA chaperone TRAM0076 shapes the transcriptome and optimizes the growth of Methanococcus maripaludis. PLoS Genet. 2019 Aug 12;15(8):e1008328. 

  5.Xiaoyan Wang#, Xien Gu#, Jie Li #,*, Lei Yue, Defeng Li, Xiuzhu Dong*. Characterization of the Methanomicrobial Archaeal RNase Zs for Processing the CCA-Containing tRNA Precursors. Front Microbiol. 2020, 11:1851.   

  6.Lei Yue #, Jie Li #,*, Bing Zhang, Lei Qi, Zhihua Li, Fangqing Zhao, Lingyan Li, Xiaowei Zheng, Xiuzhu Dong*. The conserved ribonuclease aCPSF1 triggers genome-wide transcription termination of Archaea via a 3'-end cleavage mode. Nucleic Acids Res. 2020, Sep 25;48(17):9589-9605.   

  7.Jie Li#,*, Yanjie Hou#, Xien Gu#, Lei Yue, Lu Guo, Defeng Li*, Xiuzhu Dong*. A newly identified duplex RNA unwinding activity of archaeal RNase J depends on processive exoribonucleolysis coupled steric occlusion by its structural archaeal loops. RNA Biol. 2020a, 17(10):1480-1491.  

  8.Lei Qi#,, Jie Li #,*, Jia Jia, Lei Yue, Xiuzhu*. DongComprehensive analysis of the pre-ribosomal RNA maturation pathway in a methanoarchaeon exposes the conserved circularization and linearization mode in archaea. RNA Biol. 2020b,17(10):1427-1441. 

  9.Jie Li#, Lei Qi#, Yang Guo, Lei Yue, Yanping Li, Weizhen Ge, Jun Wu, Wenyuan Shi, Xiuzhu Dong*. Global mapping transcriptional start sites revealed both transcriptional and post-transcriptional regulation of cold adaptation in the methanogenic archaeon Methanolobus psychrophilus. Sci Rep. 2015; 5:9209. 

  10.Yi Cao, Jie Li, Na Jiang, Xiuzhu Dong*. Mechanism for stabilizing mRNAs involved in methanol-dependent methanogenesis of cold-adaptive Methanosarcina mazei zm-15. Appl Environ Microbiol. 2014; 80(4):1291-8.  

  11.Tong H#*, Dong Y#, Wang X#, Hu Q, Yang F, Yi M, Deng H, Dong X*. Redox-regulated adaptation of Streptococcus to hydrogen peroxide stress. mSystems, 2020; 5: e00006-20. 

  12.Wang X, Cai J, Shang N, Zhu L, Shao NN, Dong X*, Tong H* The carbon catabolite repressor CcpA mediates optimal competence development in Streptococcus oligofermentans through post-transcriptional regulation. Mol Microbiol, 2019, 112: 552-568. 

  13.Tong H#*, Hu Q, Zhu L, Dong X*. Prokaryotic aquaporins. Cells, 2019, 8: 1316.  

  14.Tong H#*, Wang X, Dong Y, Hu Q, Zhao Z, Zhu Y, Dong L, Bai F, Dong X*. A Streptococcus aquaporin acts as peroxiporin for efflux of cellular hydrogen peroxide and alleviation of oxidative stress. J Biol Chem, 2019, 294:4583-4595. 

  15.Chen Z, Wang X, Yang F, Hu Q, Tong H*, Xiuzhu Dong*. Molecular insights into hydrogen peroxide sensing mechanism of the metalloregulator MntR in controlling bacterial resistance to oxidative stresses. J Biol Chem, 2017, 292: 5519-5531. 

  16.Wang X, Tong H*, Dong X. PerR-regulated manganese ion uptake contributes to oxidative stress defense in an oral Streptococcus. Appl Environ Microbiol. 2014. 80: 2351-2359.