生物信息和计算生物学研究组

 组长:王军 博士、研究员

  研究组研究方向
   

1. 人体健康和疾病中的微生物组成、功能以及动力学

2. 人工智能方法及其在微生物组分析中的应用

3. 微生物与宿主相互作用的研究

4. 新型测序技术以及其他组学分析技术的应用

 

 研究组研究内容及意义

 

近年来测序技术的快速发展已经使生物学进入了大数据时代,生物数据的广度和数量能够使我们为很多之前未解决的生物学问题提供答案。利用生物信息学技术和统计学技术,将现有和未来的测序技术产生的组学数据进行有机的整合和分析,能够在多个领域和层面上解释生物学现象或者提出新的假设。在人和其他模式动物中我们利用多种组学研究他们的生态和进化,在医学的框架内研究健康以及疾病的发生,其中的一个重点则是不同菌群自身的结构功能,以及和宿主的相互作用及其影响。

 

 

 研究组长


研究组长:王军

电子邮件:junwang#im.ac.cn(请将#换为@

通讯地址:北京市朝阳区北辰西路1号院3号

邮政编码:100101

 

 

 主要学习及工作经历 

 

2004-2008: 中国海洋大学生物技术本科,优秀毕业生

2008-2010: 欧盟Erasmus Mundus奖学金资助,获得比利时根特大学,西班牙奥维耶多 大学,德国不来梅大学联合硕士,最高成绩等级毕业(graduate with greatest distinction)

2010:德国不来梅马普海洋微生物研究所,硕士论文

2010-2014: 德国普伦马普进化生物学研究所,最高成绩等级毕业(summa cum laude)

 

 

 获奖情况  

 

2016 获弗拉芒自然基金支持

2014 国家自费留学生奖学金

2012 –2014 DFG博士奖学金

2010 马普学会博士奖学金

2008 –2010 欧盟Erasmus Mundus硕士奖学金

  

 

 研究队伍

 

工作人员 

         博士 助理研究员(2017- 

          博士 助理研究员(2017- 

      徐嘉悦 博士 助理研究员(2018- 

      汤静思 博士 博士后(2020- 

项目聘用 

      杨梓薇 硕士    理(2018- 

          硕士 实验员(2019- 

      鲁晶晶 硕士 实验员(2019- 

          学士 实验员(2019- 

      张文慧 学士 实验员(2019- 

在读研究生 

      徐西占 博士生(2017- 

          博士生(2018- 

          博士生(2018- 

      曹佳宝 博士生(2019- 

      许亚昆 硕士生(2017- 

      夏彬彬 硕士生(2018- 

      刘小林 硕士生(2019- 

      王梓玉 硕士生(2019- 

      张雨青 硕士生(2019- 

客座人员 

         硕士生(沈阳药科大学,2019- 

 

 

 代表性论文 

 

Xizhan Xu, Zezheng Gao, Fuquan Yang, Yingying Yang, Liang Chen, Lin Han, Na Zhao, Jiayue Xu, Xinmiao Wang, Yue Ma, Lian Shu, Xiaoxi Hu, Na Lyu, Yuanlong Pan, Baoli Zhu, Linhua Zhao, Xiaolin Tong*,Jun Wang*. Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota are Attributable to Its Key Ingredient, Berberine.Genomics, Proteomics & Bioinformatics. In press

Wei Zheng, Yue Ma, Ai Zhao, Tingchao He, Na Lyu,Ziqi Pan, Geqi Mao, Yan Liu, Jing Li, Peiyu Wang,Jun Wang*, Baoli Zhu* & Yumei Zhang*. Compositional and functional differences in human gut microbiome with respect to equol production and its association with blood lipid level: a cross-sectional study.Gut Pathogens2019, 11:20 doi:10.1186/s13099-019-0297-6

Jun Wang#, Alexander Kurilshikov, Djawad Radjabzadeh, Williams Turpin, Kenneth Croitoru, Marc Jan Bonder, Matthew A. Jackson, Carolina Medina-Gomez, Fabian Frost, Georg Homuth, Malte Rühlemann, David Hughes, Han-na Kim, MiBioGen Consortium Initiative, Tim D. Spector, Jordana T. Bell, Claire J. Steves, Nicolas Timpson, Andre Franke, Cisca Wijmenga, Katie Meyer, Tim Kacprowski, Lude Franke, Andrew D. Paterson, Jeroen RaesRobert KraaijAlexandra Zhernakova. Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.Microbiome, 2018 6:101

Jun Wang#, Liang Chen, Na Zhao, Xizhan Xu, Yakun Xu, Baoli Zhu. Of genes and microbes: solving the intricacies in host genomes.Protein Cell. 2018 9(5):446-461

Jun Wang*, Louise B. Thingholm , Jurgita Skiecevi?ien?, *, Philipp Rausch, Martin Kummen, Johannes R. Hov, Frauke Degenhardt, Femke-Anouska Heinsen, Malte C. Rühlemann, Silke Szymczak, Kristian Holm, T?nu Esko, Jun Sun, Mihaela Pricop-Jeckstadt, Samer Al-Dury, Pavol Bohov, J?rn Bethune, Felix Sommer, David Ellinghaus, Rolf K. Berge, Matthias Hübenthal, Manja Koch, Karin Schwarz, Gerald Rimbach, Patricia Hübbe, Wei-Hung Pan, Raheleh Sheibani-Tezerji, Robert H?sler, Philipp Rosenstiel, Mauro D’Amato, Katja Cloppenborg-Schmidt, Sven Künzel, Matthias Laudes, Hanns-Ulrich Marschal, Wolfgang Lieb, Ute N?thlings, Tom H. Karlsen, John F. Baines, Andre Franke. Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.Nature Genetics, 2016 (48)1396–1406 (* contributed equally; Nature Genetics封面文章)

Gwen Falony*, Marie Joossens*, Sara Vieira-Silva*,Jun Wang*, Youssef Darzi, Karoline Faust, Alexander Kurilshikov, Marc Jan Bonder, Mireia Valles-Colomer, Doris Vandeputte , Raul Y Tito, Samuel Chaffron, Leen Rymenans, Chlo? Verspecht, Lise De Sutter, Gipsi Lima-Mendez, Kevin D'hoe, Karl Jonckheere, Daniel Homola, Roberto Garcia, Ettje F. Tigchelaar, Linda Eeckhaudt, Jingyuan Fu, Liesbet Henckaerts, Alexandra Zhernakova, Cisca Wijnenga, Jeroen Raes. Population-level analysis of gut microbiome variation.Science, 2016, 352(6285):560-565  (* contributed equally; Science封面文章)

Alexander R. Moschen*, Romana R. Gerner*,Jun Wang*, Victoria Klepsch, Timon E. Adolph, Simon J. Reider, Hubert Hackl, Alexandra Pfister, Johannes Schilling, Patrizia L. Moser, Sarah L. Kempster, Alexander Swidsinski, Dorothea Orth?H?ller, Günter Weiss, John F. Baines, Arthur Kaser, Herbert Tilg. Lipocalin 2 protects from colonic inflammation and tumorigenesis through its microbiota modulating properties.Cell Host Microbes, 2016, 19(4):455–469 (* contributed equally)

Jun Wang, Shirin Kalyan, Natalie Steck, Leslie M. Turner, Bettina Harr, Sven Künzel, Marie Vallier, Robert H?sler, Andre Franke, Hans-Heinrich Oberg, Saleh M. Ibrahim, Guntram A. Grassl, Dieter Kabelitz, John F. Baines. Analysis of intestinal microbiota in hybrid house mice reveals evolutionary divergence in a vertebrate hologenome.Nature Communications2015, 6:6440.

Jun Wang, Miriam Linnenbrink, Sven Künzel, Ricardo Fernandes, Marie-Josée Nadeau, Philip Rosenstiel, John F Baines. Dietary history contributes to enterotype-like clustering and functional metagenomic content in the intestinal microbiome of wild mice.Proceedings of the National Academy of Sciences2014, 11(26):E2703-E2710.

Miriam Linnenbrink*,Jun Wang*, Emilie A Hardouin, Sven Künzel, Dirk Metzler, John F Baines: The role of biogeography in shaping diversity of the intestinal microbiota in house mice.Molecular Ecology2013, 22(7):1904-1916.

 

 

 研究中代表性图片

 

2016Science特刊封面:Microbiota at work 

2016年Nature Genetics封面:Human-Microbiota genomics 

人(右半部分)和小鼠(左半部分)中影响肠道微生物的基因位点(2016Nature Genetics  

 

 

申请专利

    

        王军,赵娜;一种依赖Nanopore单分子测序的多组学测序及分析技术;申请号:201910048654.4