|
林白雪 博士 项目研究员 |
|
研究方向 代谢工程与合成生物学
研究内容
利用代谢工程和合成生物学手段，以微生物细胞工厂生物合成中的关键问题为导向，通过微生物底盘的设计、前体和辅因子的系统改造以及模块间的协调优化等策略，提高细胞工厂的合成效率，开发具有不同应用价值的细胞工厂，实现高附加值化学品的高效、绿色生物制造，应用于食品、医药、农业等方面。
|
|
导师简介
导师姓名：林白雪 电话：010-64807798（0） 电子邮件：linbx#im.ac.cn（请将#换为@） 通讯地址：北京市朝阳区北辰西路1号院3号 邮政编码：100101
|
|
主要学习及工作经历
工作经历 2021.11-至今 中国科学院微生物研究所,项目研究员 2015.09-2021.11 中国科学院微生物研究所，副研究员 2016.08-2016.11 University of Delaware,访问学者 2013.03-2015.09 中国科学院微生物研究所，助理研究员 2010.09-2013.03 中国科学院微生物研究所，博士后 2003.07-2010.09 福建农林大学,研究实习员、助理研究员
学习经历 2006.09-2010.07 福建农林大学，生化与分子生物学专业,博士学位 2000.09-2003.07 华南理工大学，发酵工程专业，硕士学位 1996.09-2000.07 华南理工大学，制药工程专业 学士学位
获奖情况 2020年度中国轻工业联合会科技进步奖二等奖
|
近年代表性研究论文（*通讯作者）
1. Qun Liu,Baixue Lin*, Yong Tao*. Improved methylation in E. coli via an efficient methyl supply system driven by betaine.Metabolic Engineering. 2022, 72:46-55. 2. Quanxiu Gao, Hao Chen, Gaoyan Wang, Wei Yang, Xiaotong Zhong, Jiezheng Liu, XiaoJing Huo, Weifeng Liu, Jianzhong Huang*, Yong Tao*,Baixue Lin*. Highly Efficient Production of Menaquinone？7 from Glucose by Metabolically Engineered Escherichia coli. ACS Synthetic Biology. 2021, 10(4): 756–765. 3. Zhanhui Wang？, Baixue Lin？, Siyu Sheng, Sicong Tan, Pengchao Wang, Yong Tao, Zhang Liu, Zhiyuan He,Jianjun Wang.Bioinspired Anti-Icing Hydrogel Enabled by Ice-Nucleating Protein.CCS Chem. 2021, 3, 473–480 4. Yiwen Zhang, Hang Zhou, Yong Tao*,Baixue Lin*. Reconstitution of the Ornithine Cycle with Arginine:Glycine Amidinotransferase to Engineer Escherichia coli into an Efficient Whole-Cell Catalyst of Guanidinoacetate. ACS Synthetic Biology. 2020;9(8):2066-2075. 5. Jiangming Zhu, Wei Yang, Bohua Wang, Qun Liu, Xiaotong Zhong, Quanxiu Gao, Jiezheng Liu, Jianzhong Huang*,Baixue Lin*and Yong Tao. Metabolic engineering ofEscherichia colifor efficient production of L-alanyl-L-glutamine. Microbial Cell Factories2020,19(1):129. 6. Quanxiu Gao，Hao Chen , Wenzhao Wang, Jianzhong Huang*, Yong Tao,Baixue Lin*. Menaquinone-7 production in engineeredEscherichia coli.World Journal of Microbiology and Biotechnology.2020, 36:132. 7. Jing Feng, Ruifeng Li, Shasha Zhang, Yifan Bu, Yanchun Chen, Yinglu Cui,Baixue Lin,Yihua Chen, Yong Tao, Bian Wu*. Bioretrosynthesis of FunctionalizedN-Heterocycles from Glucose via One-Pot Tandem Collaborations of Designed Microbes.Advanced Science, 2020, 7(17) 2001188. 8. Shasha Zhang, Wei Yang, Hao Chen, Bo Liu,Baixue Lin*, Yong Tao*. Metabolic engineering for effcient supply of acetyl-CoA from different carbon sources in Escherichia coli.Microbial Cell Factories. 2019,18:130. 9. Xiaoyu Piao, Lei Wang,Baixue Lin, Hao Chen, Weifeng Liu *, Tao Yong*. Metabolic engineering of Escherichia coli for production of L-aspartate and its derivative beta-alanine with high stoichiometric yield. Metabolic engineering, 2019, 54:244-254 10.Baixue Lin*, Yong Tao*. Whole-cell biocatalysts by design.Microbial Cell Factories, 2017, 16:106. 11. Xun Lv, Hongzhi Cao,Baixue Lin*, Wei Wang, Wande Zhang, Qian Duan, Yong Tao, Xue-Wei Liu, Xuebing Li*. Synthesis of sialic acids, their derivatives and analogues using a whole-cell catalyst.Chemistry - A European Journal,2017,23(26): 15143–15149. 12. Pengchao Wang, Xinwei Yang,Baixue Lin*, Jianzhong Huang*, Yong Tao*. Cofactor self-sufficient whole-cell biocatalysts for the production of 2-phenylethanol.Metabolic Engineering, 2017,44:143-149. 13.Baixue Lin*, Yu Qiao, Bo Shi, Yong Tao. Polysialic acid biosynthesis and production inEscherichia coli: Current state and perspectives.Applied Microbiology and Biotechnology, 2016,100(1):1-8. 14. Keqiang Fan,Baixue Lin, Yong Tao, Keqian Yang*. Engineering deacetoxycephalosporin C synthase as a catalyst for the bioconversion of penicillins.Journal of Industrial Microbiology & Biotechnology.2016,44(4): 705-710. 15. Fang Chen, Yong Tao, Cheng Jin, Yang Xu,Baixue Lin*. Enhanced production of polysialic acid by metabolic engineering ofEscherichia coli.Applied Microbiology and Biotechnology, 2015,99:2603-2611. 16.Baixue Lin, Keqiang Fan, Jian Zhao, Junjie Ji, Linjun Wu, Keqian Yang*, Yong Tao*. Reconstitution of TCA cycle with DAOCS to engineerE. coliinto an efficient whole cell catalyst of penicillin G.Proc Natl Acad Sci USA, 2015,112(32):9855-9. 17.Baixue Lin, Zijuan Zhang, Weifeng Liu,Zhiyang Dong, Yong Tao*. Enhanced production of N-acetyl-D-neuraminic acid by multi-approach whole-cell biocatalyst.Applied Microbiology and Biotechnology, 2013, 97: 4775-84. |
授权专利
1. 林白雪,朱江明,陶勇.产丙谷二肽的工程菌及其构建方法与应用. ZL201911164379.9. 2. 林白雪,朱江明,陶勇.产L-谷氨酰胺的工程菌及其构建方法与应用. ZL201911362098.4. 3. 林白雪，高全秀，陶勇.一种产MK-7的重组大肠杆菌及其构建方法和应用. ZL201911210070.9. 4. 林白雪，张译文，周航，陶勇.产胍基乙酸的工程菌及其构建方法与应用. ZL201910247604.9. 5. 林白雪，梁秀君，朴晓宇，张莎莎，陶勇.产左旋肉碱的重组菌及其构建方法与应用. ZL201811252374.7. 6. 刘伟丰，朴晓宇，林白雪，陶勇.生产L-天冬氨酸的平台菌、基于该平台菌构建的生产β-丙氨酸的重组菌及其构建方法.ZL 201910270484.4. 7. 陈楠，刘伟丰，林白雪，陶勇.高生物量和/或高生长速度重组菌及其构建方法与应用. ZL 201410167194.4。 8. 林白雪,袁慎键,杨巍,陶勇.海藻糖的生产方法.中国，专利号：ZL 201610249035.8. 9. 林白雪，王鹏超，陶勇.产2-苯乙醇的基因工程菌及其应用方法.专利号: ZL 201510650028.4. 10. 林白雪，刘伟丰，傅震洲，陶勇.用于制备反式-4-羟基-L-脯氨酸的DNA分子和方法.专利号：ZL 201610244420.3 11. 林白雪，崔丽，袁慎键，陶勇.一种生产反式-4-羟基-L-脯氨酸的工程菌及其构建方法与其应用.专利号：ZL 201610248615.5. 12. 林白雪，张莎莎，杨巍，王鹏超，陶勇.产N-乙酰谷氨酸的基因工程菌及其构建方法与应用.中国，专利号：ZL 201810789222.4. 13. 林白雪，张莎莎，史从容，陶勇.产L-鼠李糖的工程菌及其构建方法与应用.中国，专利号：ZL 201810517051.X. 14. 于瑶，韩剑，林白雪，陶勇.一种检测待测样本中目标蛋白的含量的方法.中国，专利号：ZL 201710306828.3. 15. 杨欣伟，黄建忠，陶勇，林白雪，柯崇榕，王鹏超.产D-苯乳酸的基因工程菌及其构建方法与应用.中国，专利号：ZL 201710623316.X 16. 林白雪，张子娟，陶勇. 产N-乙酰神经氨酸的基因工程菌及其构建方法与应用.中国，专利号：ZL201210349623.0. |
|
|
