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孙蕾 博士 项目研究员 |
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研究方向 病毒感染与免疫及抗病毒/抗炎症药物研究
研究内容
流感等病毒感染与宿主免疫应答的调控机制、炎症疾病的调控机制、抗病毒/抗炎症制剂研究。 |
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导师姓名：孙蕾 电话：010-64807503 电子邮件：sunlei362#im.ac.cn（请将#换为@） 通讯地址：北京市朝阳区北辰西路1号院3号 邮政编码：100101
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工作经历 2019.10– 至今 中国科学院微生物研究所，项目研究员 2011.08–2012.11 美国康奈尔大学威尔康奈尔医学院，访问助理教授 2009.06–2019.10 中国科学院微生物研究所，副研究员 2005.07–2009.06 中国科学院微生物研究所，助理研究员 学习经历 2000.09–2005.06 扬州大学预防兽医学专业，博士学位 1996.09–2000.09 山东农业大学兽医专业，学士学位 |
近年代表性研究论文（*通讯作者）
1. Xiaoyuan Bai#, Wenxian Yang#, Yuna Zhao, Tongtong Cao, Runshan Lin, Pengtao Jiao, Heqiao Li, Huizi Li, Jie Min, Xiaoxiao Jia, He Zhang, Wenhui Fan, Xiaojuan Jia, Yuhai Bi, Wenjun Liu,Lei Sun*. The extracellular cyclophilin A-integrin β2 complex as a therapeutic target of viral pneumonia.Molecular Therapy,2024, 32:1510-1525. 2. Wenxian Yang#, Xiaoyuan Bai#, Xiaoxiao Jia, Huizi Li, Jie Min, Heqiao Li, Haoran Zhang, Jianjing Zhou, Yuna Zhao, Wenjun Liu, Haiming Xin*,Lei Sun*. The binding of extracellular cyclophilin A to ACE2 and CD147 triggers psoriasis-like inflammation.Journal of Autoimmunity, 2024, 148:103293.
3. Pengtao Jiao#, Jianing Ma#, Yuna Zhao#, Xiaoxiao Jia, Haoran Zhang, Wenhui Fan, Xiaojuan Jia*, Xiaoyuan Bai, Yiqi Zhao, Yongxu Lu, He Zhang, Jiayin Guo, Gang Pang, Ke Zhang, Min Fang, Minghua, Li, Wenjun Liu, Geoffrey L. Smith*,Lei Sun*.The nuclear localization signal of monkeypox virus protein P2 orthologue is critical for inhibition of IRF3-mediated innate immunity.Emerging Microbes & Infections, 2024, 13(1):2372344.
4. Pengtao Jiao, Wenhui Fan, Xiaoya Ma, Runshan Lin, Yuna Zhao, Yabo Li, He Zhang, Xiaojuan Jia, Yuhai Bi, Xiaoli Feng, Minghua Li, Wenjun Liu, Ke Zhang*,Lei Sun*. SARS-CoV-2 nonstructural protein 6 triggers endoplasmic reticulum stress-induced autophagy to degrade STING1.Autophagy, 2023, 19:3113-3131.
5. Pengtao Jiao#, Shuchao Wang#, Wenhui Fan#, He Zhang, Hongyan Yin, Yingli Shang, Hongfei Zhu, Wenjun Liu, Rongliang Hu,Lei Sun*. Recombinant porcine interferon cocktail delays the onset and lessens the severity of African swine fever.Antiviral Research, 2023, 215:105644. 6. Huizi Li, Wenhui Fan*, Jie Min, Xiaoyuan Bai, Wenxian Yang, Heqiao Li, Yuna Zhao, Runshan Lin, Xiaojuan Jia, Wenjun Liu*,Lei Sun*. Cyclophilin A facilitates influenza B virus replication by stabilizing viral proteins.IScience, 2023, 26:108515.
7. Heqiao Li, Wenxian Yang, Huizi Li, Xiaoyuan Bai, He Zhang, Wenhui Fan, Wenjun Liu*,Lei Sun*. PROTAC targeting cyclophilin A controls virus-induced cytokine storm.IScience,2023, 26:107535.
8. Wenxian Yang, Xiaoyuan Bai, Xiaohan Luan, Jie Min, Xiaodong Tian, Heqiao Li, Huizi Li, Wenqiang Sun, Wei Liu, Wenhui Fan, Wenjun Liu*,Lei Sun*. Delicate regulation of IL-1β-mediated inflammation by cyclophilin A.Cell Reports, 2022, 38:110513.
9.Xiaoyuan Bai, Wenxian Yang, Heqiao Li, Yuna Zhao, Wenhui Fan, He Zhang, Wenjun Liu,Lei Sun*. Cyclosporine A regulates influenza A virus-induced macrophages polarization and inflammatory responses by targeting cyclophilin A.Frontiers in Immunology, 2022, 13:861292.
10. Wenqiang Sun, Lihong He, Huicong Lou, Wenhui Fan, Limin Yang, Gong Cheng, Wenjun Liu*,Lei Sun*. The cross-protective immunity landscape among different SARS-CoV-2 variant RBDs.Frontiers in Immunology, 2022, 13:898520.
11. Xiaoyuan Bai, Wenxian Yang, Xiaohan Luan, Huizi Li, Heqiao Li, Deyu Tian, Wenhui Fan, Jing Li, Beinan Wang, Wenjun Liu*,Lei Sun*. Induction of cyclophilin A by influenza A virus infection facilitates group A Streptococcus coinfection.Cell Reports, 2021, 35, 109159. 12.Weinan Zheng#, Liang Cui#, Minghui Li#, Yun Li, Wenhui Fan, Limin Yang, Jing Li,Lei Sun*, Wenjun Liu. Nucleoprotein phosphorylation site (Y385) mutation confers temperature sensitivity to influenza A virus due to impaired nucleoprotein oligomerization at a lower temperature.Science China-Life Sciences, 2021, 64(4):633-643.
13. Xiaohan Luan#, Wenxian Yang#, Xiaoyuan bai, Heqiao Li, Huizi Li, Wenhui Fan, He Zhang, Wenjun Liu,Lei Sun*. Cyclophilin A is a key positive and negative feedback regulator within interleukin-6 trans-signaling pathway.FASEB Journal, 2021, 35:e21958.
14. Weinan Zheng, Wenhui Fan, Shuang Zhang, Pengtao Jiao, Yingli Shang, Liang Cui, Madina · Mahesutihan, Jing Li, Dayan Wang, George Fu Gao,Lei Sun*, Wenjun Liu. Naproxen exhibits broad anti-influenza virus activity in mice by impeding viral nucleoprotein nuclear export.Cell Reports, 2019, 27:1875–1885.
15. Wei Liu#, Jing Li#, Weinan Zheng, Yingli Shang, Zhendong Zhao, Shanshan Wang, Yuhai Bi, Shuang Zhang, Chongfeng Xu, Ziyuan Duan, Lianfeng Zhang, Yue L. Wang, Zhengfan Jiang, Wenjun Liu*,Lei Sun*. Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses.eLife,2017, 6:e24425.（获F1000推荐和点评） |
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