代焕琴导师简介

 代焕琴博士、副研究员

 研究方向
   

抗代谢综合征天然药物与微生态药物研究 

 研究内容

利用基因组、转录组等技术挖掘微生物资源及其活性次生代谢产物，建立抗代谢综合征等多种活性筛选模型，筛选影响微生物群落和人体微生态平衡体系的活性物质，并进行作用机制研究。
 

  导师简介

 主要学习及工作经历 

2011.8-至今           中国科学院微生物研究所，副研究员 

2015.12-2017.12      美国波士顿儿童医院，   访问学者 

2009.2-2011.7         中国科学院微生物研究所，助理研究员 

2006.5-2009.1         中国科学院微生物研究所，博士后 

2002.9-2006.2         中国科学院昆明植物研究所， 博士学位 

1999.9-2002.6         北京林业大学， 硕士学位 

1995.9-1999.6.         河北农业大学， 学士学位 

 近年代表性研究论文(*通讯作者) 

1.  Xie F, Dai S, Zhao Y, Huang P, Yu S, Ren B, Wang Q, Ji Z, Alterovitz G, Zhang Q, Zhang J, Chen X, Jiang L, Song F, Liu H, Ausubel FM, Liu X*,Dai H*, Zhang L*.Generation of Fluorinated Amychelin Siderophores againstPseudomonas aeruginosaInfections by a Combination of Genome Mining and Mutasynthesis.Cell Chem Biol. 2020 Nov 5:S2451-9456(20)30425-6. doi: 10.1016/j.chembiol.2020.10.009. 

2.  Zhang J, Chen B, Liang J, Han J, Zhou L, Zhao R, Liu H*,Dai H*. Lanostane Triterpenoids with PTP1B Inhibitory and Glucose-Uptake Stimulatory Activities from MushroomFomitopsis pinicolaCollected in North America. J Agric Food Chem. 2020 Sep 16;68(37):10036-10049. doi: 10.1021/acs.jafc.0c04460. Epub 2020 Sep 4. PMID: 32840371. 

3.  Zhang L, Zhang J, Ren B, Lu W, Hou C, Wang J, Ma X, Ma R, Liu M, Liu Z, Li JP, Ding K,Dai H*, Zhang L, Liu X*. Characterization of anti-BCG benz[α]anthraquinones and new siderophores from a Xinjiang desert-isolated rare actinomyceteNocardia sp. XJ31. Appl Microbiol Biotechnol. 2020 Oct;104(19):8267-8278. doi: 10.1007/s00253-020-10842-2. Epub 2020 Aug 24. PMID: 32830291; PMCID: PMC7443361. 

4.   Zhang J, Li B, Qin Y, Karthik L, Zhu G, Hou C, Jiang L, Liu M, Ye X, Liu M, Hsiang T,Dai H*, Zhang L*, Liu X*. A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derivedVerrucosispora sp. MS100137. Appl Microbiol Biotechnol. 2020 Feb;104(4):1533-1543. doi: 10.1007/s00253-019-10217-2. Epub 2020 Jan 2. PMID: 31894364. 

5.  Baldry M, Nielsen A, Bojer MS, Zhao Y, Friberg C, Ifrah D, Glasser Heede N, Larsen TO,Fr？ki？r H, Frees D, Zhang L,Dai H*, Ingmer H*. Norlichexanthone Reduces Virulence Gene Expression and Biofilm Formation inStaphylococcus aureus. PLoS One. 2016 Dec22;11(12):e0168305. doi: 10.1371/journal.pone.0168305. eCollection 2016. 

6.  Cui J, Ren B, Tong Y,Dai H*, Zhang L*. Synergistic combinations of antifungals and anti-virulence agents to fight againstCandida albicans. Virulence. 2015;6(4):362-71. doi: 10.1080/21505594.2015.1039885. PMID: 26048362; PMCID: PMC4601232. 

7.  Zhang X, Guo H, Li Z, Song F, Wang W,Dai H*, Zhang L*, Wang J*. Synthesis and evaluation of isatin-β-thiosemicarbazones as novel agents against antibiotic-resistant Gram-positive bacterial species. Eur J Med Chem. 2015 Aug 28;101:419-30. doi: 10.1016/j.ejmech.2015.06.047. Epub 2015 Jul 2. PMID: 26185006. 

8. Xie F, Dai S, Shen J, Ren B, Huang P, Wang Q, Liu X, Zhang B,Dai H*, Zhang L*. A new salicylate synthase AmS is identified for siderophores biosynthesis inAmycolatopsis methanolica239(T). Appl Microbiol Biotechnol. 2015 Jul;99(14):5895-905. doi: 10.1007/s00253-014-6370-7. Epub 2015 Jan 15. PMID: 25586582.