程水红导师简介

 程水红博士、副研究员

 研究方向
   

抗感染药物
 

 研究内容

从分子水平分析病原菌的感染机制，通过计算化学分析感染过程中关键蛋白与配体的相互作用，据此设计新型抗感染药物分子，通过有机化学的方法合成药物，并进行系统的活性评估，筛选具有进一步研发潜力的候选药物。
 

  导师简介

 主要学习及工作经历 

 工作经历

2009.07-至今：中国科学院微生物研究所，副研究员

2017.09-2018.08：美国伦斯勒理工学院，访问学者

 学习经历

2004.09-2009.07：中科院生态环境研究中心，糖化学，博士学位

2000.09-2004.07：北京大学医学部，药学，学士学位

 近年代表性研究论文(*通讯作者) 

Mingli Li^？, Shuihong Cheng^？, Yibo Ding, Chen Wang, Yong Feng, Wenzhao Wang, Liying Ma*, Xuebing Li*.Polyethylene glycol 40-modified peptide with high therapeutic efficacy in simian-human immunodeficiency virus-acutely infected rhesus monkeys.J. Virol.2020,94(14), e00386-20. 

Fuming Zhang*, Langhong Zheng,Shuihong Cheng, Yanfei Peng, Li Fu, Xing Zhang, Robert Linhardt *，Comparison of the interactions of different growth factors and glycosaminoglycans.Molecules,2019,24(18), 3360. 

Chen Wang,Shuihong Cheng, Yuanyuan Zhang, Yibo Ding, Huihui Chong, Hui Xing, Shibo Jiang, Xuebing Li*, Liying Ma*. Long-acting HIV-1 fusion inhibitory peptides and their mechanisms of action. Viruses, 2019,11(9), 811. 

袁雪，孙欢，丁超，程水红*，傅立峰，李学兵*。大肠杆菌细胞壁肽聚糖的化学修饰及荧光标记。微生物学报，2020,60(1), 49–59。 

Shuihong Cheng,Paeton L. Wantuch, Megan E. Kizer, Dustin R. Middleton, Ruitong Wang, Mikaela DiBello, Mingli Li, Xing Wang, Xuebing Li, Vasanthi Ramachandiran, Fikri Y. Avci, Fuming Zhang, Xing Zhang*, Robert J. Linhardt*.Glycoconjugate synthesis using chemoselective ligation.Org. Biomol. Chem.,2019,17, 2646–2650. 

Shuihong Cheng, Peixing Wu, Jing Han, Yiren Wang, Yuting Cui, Zhenxing Zhang, Tatsuya Yamagata, Xuebing Li*. Synthesis and biological evaluation of neoglycosphingolipids.Eur. J. Med. Chem.,2017, 134, 43–51. 

Shuihong Cheng^#, Yan Wang^#, Zhenxing Zhang, Xun Lv, George F Gao, Yiming Shao, Liying Ma, Xuebing Li *. Enfuvirtide-PEG conjugate: A potent HIV fusion inhibitor with improved pharmacokinetic properties.Eur. J. Med. Chem.2016, 121, 232–237. 

Shuihong Cheng,Xuesong Chang, Yan Wang, George F. Gao,Yiming Shao, Liying Ma, Xuebing Li*.Glycosylated enfuvirtide: A long-lasting glycopeptide with potent anti-HIV activity.J. Med. Chem.,2015,58(3), 1372–1379. 

    Shuihong Cheng, Huiqin Zhao, Yaozu Xu, Yawei Yang, Xun Lv, Peixing Wu*, Xuebing Li*, Inhibition of influenza virus infection with chitosan-sialyloligosaccharides ionic complex.Carbohyd. Polym.2014,107, 132–137. 

Jinhua Wei#, Longtang Zheng#, Xun Lv#, Yuhai Bi, Wenwen Chen, Wei Zhang, Yi Shi, Lei Zhao, Xiaoman Sun, Fei Wang,Shuihong Cheng, Jinghua Yan, Wenjun Liu, Xingyu Jiang, George F Gao, Xuebing Li*. Analysis of influenza virus receptor apecificity using glycan-functionalized gold nanoparticles,ACS nano,2014,8(5), 4600–4607. 

Jinhua Wei, Xun Lv, Yang Lü, Gangzhu Yang, Lifeng Fu, Liu Yang, Jianjun Wang, Jianhui Gao,Shuihong Cheng, Qian Duan, Cheng Jin, Xuebing Li*. Glycosynthase with broad substrate specificity an efficient biocatalyst for the construction of oligosaccharide library.Eur. J. Org. Chem.,2013,12, 2414–2419. 

Xuebing Li*, Peixing Wu,Shuihong Cheng,Xun Lv. Synthesis and assessment of globotriose–chitosan conjugate, a novel inhibitor of shiga toxins produced byEscherichia coli.J. Med. Chem.,2012,55(6), 2702–2710. 

Xuebing Li*, Peixing Wu, George F. Gao,Shuihong Cheng. Carbohydrate-functionalized chitosan fiber for influenza virus capture.Biomacromolecules,2011,12, 3962–3969.