New cryptotanshinone derivatives with anti-influenza A virus activities obtained via biotransformation by Mucor rouxii----中国科学院微生物研究所

科研成果

论文题目:	New cryptotanshinone derivatives with anti-influenza A virus activities obtained via biotransformation by Mucor rouxii
作者:	He Wenni, Li Yao, Qin Yuejie, Tong Xiaomei, Song Zhijun, Zhao Yu, Wei Ran, Li Li, Dai Huanqin, Wang Wenzhao, Luo Houwei, Ye Xin, Zhang Lixin, and Liu Xueting.
联系作者:
刊物名称:	Appl Microbiol Biotechnol
期:	101
卷:	16
页:	6365-6374
年份:	2017
影响因子:	3.716
论文下载:	https://link.springer.com/article/10.1007%2Fs00253-017-8351-0
摘要:	This paper provides an efficient platform to diversify the structure and pharmaceutical potentials of known natural products. Seven metabolites were obtained via the biotransformation of cryptotanshinone by the fungus Mucor rouxii AS 3.3447, and assigned as 13R-14R-hydroxy-anhydride of 16R-cryptotanshinone (1), 1S-hydroxy-anhydride of 16R-cryptotanshinone (2), 1R-hydroxy-anhydride of 16R-cryptotanshinone (3), 3S-hydroxy-epicryptoacetalide (4), 3S-hydroxy-cryptoacetalide (5), epicryptoacetalide (6), and cryptoacetalide (7). Among these compounds, 1-5 are novel. The ortho-naphthoquinone chromophore of cryptotanshinone was degraded and rearranged by M. rouxii. 1 and 3 showed good anti-influenza A virus activities with the reduced cytotoxic activities compared to the parent substrate cryptotanshinone (8). The structures of all the new compounds were determined on the basis of HRESIMS (high-resolution electrospray ionization mass spectroscopy) spectrometry, NMR (nuclear magnetic resonance) spectroscopy, ECD (electronic circular dichroism) calculations, and the CD (circular dichroism) of "in situ" method with [Rh2(OCOCF3)4].