| 论文题目: | An mRNA-based vaccine strategy against Zika |
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| 作者: | Wong G., and Gao G. F. |
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| 刊物名称: | Cell Res |
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| 年份: | 2017 |
| 影响因子: | 12.393 |
| 论文下载: | https://www.nature.com/cr/journal/vaop/ncurrent/full/cr201753a.html |
| 摘要: | Infections with Zika virus are strongly associated with complications such as congenital microcephaly and can trigger Guillain-Barre syndrome in humans, highlighting the urgent need for a safe, efficacious vaccine as a preventative countermeasure. In a recent paper published in Cell, Richner et al. generated a lipid nanoparticle encapsulated modified mRNA vaccine encoding the prM and E genes from Zika virus, which showed protection and sterilizing immunity in immunocompetent mice. |
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