| 论文题目: | Toll-like Receptor 2-and 4-Mediated Reciprocal Th17 and Antibody Responses to Group A Streptococcus Infection |
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| 作者: | Wang Xiaoshuang, Fan Xin, Bi Shuai, Li Ning, and Wang Beinan*. |
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| 刊物名称: | Journal of Infectious Diseases |
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| 年份: | 2016 |
| 影响因子: | 5.888 |
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| 摘要: | Background The role of Toll-like receptors (TLRs) in adaptive immunity is incompletely understood. Recurrent human infections by Group A Streptococcus (GAS) and associated autoimmune conditions suggest that the immunity to GAS is intricately regulated and TLRs may be involved in the regulation.Methods This study investigated adaptive mucosal immune responses to GAS in TLR2-/- and TLR4-/- mice with an intranasal infection model.Results FACS analyses of Nasal-Associated Lymphoid Tissue (NALT) cells showed that robust Th17 responses to GAS in WT mice were reduced in TLR2-/- mice by 50%. Conversely, antibody levels and follicular T (TFH) and B cells in germinal center of NALT were significantly higher in TLR2-/- than in WT mice. However, antibody response to soluble antigens co-immunized with GAS was similar in WT and TLR2-/- mice. Moreover, the adaptive clearance of GAS in TLR2-/- mice was as efficient as in WT mice, whereas, it was significantly impaired in TLR4-/- mice, in which antibody responses were significantly lower than in WT mice.Conclusion Activation of TLR2 by GAS is responsible for massive Th17 activation and deficient antibody response, which may increase predisposition to GAS-related autoimmunity and reduce efficiency of protection. |
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