3-Anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection----中国科学院微生物研究所

科研成果

论文题目:	3-Anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection
作者:	Wang, Song Luo, Xiaoqin Yan, Ruoxiang Wang, Quanxin Qi, Qiuyue Chi, Xiaojuan Zhang, Lanlan Yu, Ziding Cai, Binxiang Chen, Ji-Long Liu, Hongwei
联系作者:
刊物名称:	Protein Cell
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年份:	2016
影响因子:	3.043
论文下载:	http://link.springer.com/article/10.1007%2Fs13238-016-0325-y
摘要:	Influenza A virus (IAV) is an enveloped negative-strand RNA virus containing eight RNA segments that belongs to the family Orthomyxoviridae and can cause acute respiratory infection in humans and animals. Although vaccination is one of the major means for prophylaxis of influenza virus infection, a particular influenza vaccine only confers protection for no more than a few years. In addition, the outbreak of novel influenza infection cannot be predicted (Gao et al., 2013). Thus, vaccine is unable to provide immediate protection against sudden influenza outbreaks with unknown identity. Development of antiviral drugs for therapeutic treatment is an important strategy to reduce the duration and severity of influenza. However, more and more drug-resistant influenza virus strains are emerging due to its antigenic drift or antigenic shift, which increases the need for new antivirals.