Bioactive Spirobisnaphthalenes and Lactones from a Cup Fungus Plectania sp Collected in the Tibet Plateau Region----中国科学院微生物研究所

科研成果

论文题目:	Bioactive Spirobisnaphthalenes and Lactones from a Cup Fungus Plectania sp Collected in the Tibet Plateau Region
作者:	Wang, Kai Bao, Li Ma, Ke Qi, Wei Song, Fuhang Yao, Yijian Yin, Wenbing Zhang, Lixin Huang, Ying Han, Junjie Liu, Hongwei
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刊物名称:	European Journal of Organic Chemistry
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年份:	2016
影响因子:	2.971
论文下载:	http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201600562/abstract
摘要:	Five new spirobisnaphthalenes (1-5), one new tetralone derivative (6), and six new lactones (7-12) together with the known compound urnucratin C (13) have been isolated from the solid culture of the cup fungus Plectania sp. The structures of the new compounds were unambiguously elucidated on the basis of one-and two-dimensional NMR spectroscopy, high-resolution mass spectrometry, and circular dichroism (CD) spectroscopy. Compounds 1-6 were found to be active against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Bacillus subtilis, and Pseudomonas aeruginosa. In addition, the cytotoxicities of 1-13 were evaluated against the HepG2 and K562 cell lines by using the CCK8 assay. Compounds 1-3 and 13 showed moderate cytotoxicity against HepG2 and K562 with IC50 values in the range 10.7-38.5 mu M. This is the first report of secondary metabolites from this cup fungus.