| 论文题目: | Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds, 2014-2015 |
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| 作者: | Bi, Yuhai Chen, Jianjun Zhang, Zhenjie Li, Mingxin Cai, Tianlong Sharshov, Kirill Susloparov, Ivan Shestopalov, Alexander Wong, Gary He, Yubang Xing, Zhi Sun, Jianqing Liu, Di Liu, Yingxia Liu, Lei Liu, Wenjun Lei, Fumin Shi, Weifeng Gao, George F. |
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| 刊物名称: | Virologica Sinica |
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| 年份: | 2016 |
| 影响因子: | 0 |
| 论文下载: | http://link.springer.com/article/10.1007%2Fs12250-016-3750-4 |
| 摘要: | A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015. Based on the genetic and phylogenetic analyses, the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA, a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin. The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain (A/Alberta/01/2014). Further analysis showed that similar viruses have been circulating in wild birds in China, Russia, Dubai (Western Asia), Bulgaria and Romania (Europe), as well as domestic poultry in some regions of Africa. The affected areas include the Central Asian, East Asian-Australasian, West Asian-East African, and Black Sea/Mediterranean flyways. These results show that the novel Clade 2.3.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds, thus posing a serious threat to wild birds and potentially humans. |
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