| 论文题目: | Single cell tells the developmental story |
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| 作者: | Zhan, Zhengyan Xu, Xin Fu, Yu V. |
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| 刊物名称: | Science Bulletin |
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| 年份: | 2016 |
| 影响因子: | 0 |
| 论文下载: | http://link.springer.com/article/10.1007%2Fs11434-016-1153-4 |
| 摘要: | Stem cells are undifferentiated cells that retain the ability to self-renew and differentiate into specialized cells, offering a promising resource to generate requisite cell types in regenerative medicine [1, 2]. Haematopoietic stem cells (HSCs) can differentiate into entire mature blood lineages, sitting at the apex of the haematopoietic hierachy and playing a key role in the long-term maintenance and stabilization of mammalian blood system functions [3, 4]. HSCs are mostly found in embryo and bone marrow, but also with small amounts in peripheral blood. Under proper condition, one single HSC is capable of reproducing all types of blood cells in vivo. HSC transplantation, usually performed as bone marrow transplantation, is now routinely used to treat patients with cancers and severe blood and immune system disorders. However, the clinical application of bone marrow transplantation is limited by the extremely strict matching requirement and scarcity of donors. Many attempts to culture self-proliferative HSCs or transform other types of cells to HSCs in vitro for bypassing the restrictions have been unsuccessful since the regulation mechanisms of HSC development remain elusive [5]. |
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