Pathogenicity Comparison Between the Kikwit and Makona Ebola Virus Variants in Rhesus Macaques----中国科学院微生物研究所

科研成果

论文题目:	Pathogenicity Comparison Between the Kikwit and Makona Ebola Virus Variants in Rhesus Macaques
作者:	Wong, Gary Qiu, Xiangguo de La Vega, Marc Antoine Fernando, Lisa Wei, Haiyan Bello, Alexander Fausther-Bovendo, Hugues Audet, Jonathan Kroeker, Andrea Kozak, Robert Tran, Kaylie He, Shihua Tierney, Kevin Soule, Geoff Moffat, Estella Gunther, Stephan Gao, George F Strong, Jim Embury-Hyatt, Carissa Kobinger, Gary
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刊物名称:	J Infect Dis
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年份:	2016
影响因子:	5.888
论文下载:	http://jid.oxfordjournals.org/content/214/suppl_3/S281.long
摘要:	Enhanced virulence and/or transmission of West African Ebola virus (EBOV) variants, which are divergent from their Central African counterparts, are suspected to have contributed to the sizable toll of the recent Ebola virus disease (EVD) outbreak. This study evaluated the pathogenicity and shedding in rhesus macaques infected with 1 of 2 West African isolates (EBOV-C05 or EBOV-C07) or a Central African isolate (EBOV-K). All animals infected with EBOV-C05 or EBOV-C07 died of EVD, whereas 2 of 3 EBOV-K-infected animals died. The viremia level was elevated 10-fold in EBOV-C05-infected animals, compared with EBOV-C07- or EBOV-K-infected animals. More-severe lung pathology was observed in 2 of 6 EBOV-C05/C07-infected macaques. This is the first detailed analysis of the recently circulating EBOV-C05/C07 in direct comparison to EBOV-K with 6 animals per group, and it showed that EBOV-C05 but not EBOV-C07 can replicate at higher levels and cause more tissue damage in some animals. Increased virus shedding from individuals who are especially susceptible to EBOV replication is possibly one of the many challenges facing the community of healthcare and policy-making responders since the beginning of the outbreak.