| 论文题目: | MERS-CoV spike protein: Targets for vaccines and therapeutics |
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| 作者: | Wang, Qihui Wong, Gary Lu, Guangwen Yan, Jinghua Gao, George F |
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| 刊物名称: | Antiviral Res. |
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| 年份: | 2016 |
| 影响因子: | 4.074 |
| 论文下载: | http://www.sciencedirect.com/science/article/pii/S0166354216301826 |
| 摘要: | The disease outbreak caused by Middle East respiratory syndrome coronavirus (MERS-CoV) is still ongoing in the Middle East. Over 1600 people have been infected since it was first reported in September 2012. Despite great efforts, licensed vaccines or therapeutics against MERS-CoV remain unavailable. The MERS-CoV spike (S) protein is an important viral antigen known to mediate host-receptor binding and virus entry, as well as induce robust humoral and cell-mediated responses in humans during infection. In this review, we highlight the importance of the S protein in the MERS-CoV life cycle, summarize recent advances in the development of vaccines and therapeutics based on the S protein, and discuss strategies that can be explored to deliver the world's first approved medical countermeasure against MERS-CoV. |
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