| 论文题目: | Lactic acid bacteria differentially regulate filamentation in two heritable cell types of the human fungal pathogen Candida albicans |
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| 作者: | Liang, Weihong Guan, Guobo Dai, Yu Cao, Chengjun Tao, Li Du, Han Nobile, Clarissa J Zhong, Jin Huang, Guanghua |
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| 刊物名称: | Mol Microbiol |
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| 年份: | 2016 |
| 影响因子: | 4.347 |
| 论文下载: | http://onlinelibrary.wiley.com/doi/10.1111/mmi.13475/abstract;jsessionid=EF30114390D224BF7EB261ABC6902709.f02t04 |
| 摘要: | Microorganisms rarely exist as single species in natural environments. The opportunistic fungal pathogen Candida albicans and lactic acid bacteria (LAB) are common members of the microbiota of several human niches such as the mouth, gut, and vagina. LAB are known to suppress filamentation, a key virulence feature of C. albicans, through the production of lactic acid and other metabolites. Here we report that C. albicans cells switch between two heritable cell types, white and opaque, to undergo filamentation to adapt to diversified environments. We show that acidic pH conditions caused by LAB and low temperatures support opaque cell filamentation, while neutral pH conditions and high temperatures promote white cell filamentation. The cAMP signaling pathway and the Rfg1 transcription factor play major roles in regulating the responses to these conditions. This cell type-specific response of C. albicans to different environmental conditions reflects its elaborate regulatory control of phenotypic plasticity. This article is protected by copyright. All rights reserved. |
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