| 论文题目: | Regulatory T cells turn pathogenic |
|---|---|
| 作者: | Guo Jitao , and Zhou Xuyu*. |
| 联系作者: | |
| 刊物名称: | Cellular & Molecular Immunology |
| 期: | 5 |
| 卷: | 12 |
| 页: | 525-532 |
| 年份: | 2015 |
| 影响因子: | 3.526 |
| 论文下载: | |
| 摘要: | Foxp3(+) regulatory T (Treg) cells are considered a sub-lineage of CD4(+) T cells that are protective against autoimmunity due to their essential roles in maintaining immune homeostasis and self-tolerance. However, Treg cells are unstable in vivo in terms of lineage specialization and suppressive function. These unstable Treg cells play roles in the pathogenesis of diseases, which cause safety concerns regarding human Treg cell therapy. In this review, we highlight recent findings that demonstrate the pathogenic conversion of Treg cells in different disease models. |
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