| 论文题目: | New Bergamotane Sesquiterpenoids from the Plant Endophytic Fungus Paraconiothyrium brasiliense |
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| 作者: | Guo Zhe, Ren Fengxia, Che Yongsheng, Liu Gang*, and Liu Ling*. |
| 联系作者: | Liu Gang*, and Liu Ling* |
| 刊物名称: | Molecules |
| 期: | 20 |
| 卷: | 8 |
| 页: | 14611-20 |
| 年份: | 2015 |
| 影响因子: | 2.791 |
| 论文下载: | |
| 摘要: | Brasilamides K-N (1-4), four new bergamotane sesquiterpenoids; with 4-oxatricyclo (3.3.1.0 (2,7))nonane (1)and 9-oxatricyclo(4.3.0.0 (4,7))nonane (2-4) skeletons; were isolated from the scale-up fermentation cultures of the plant endophytic fungus Paraconiothynium brasiliense Verkley. The previously identified sesquiterpenoids brasilamides A and C (5 and 6) were also reisolated in the current work. The structures of 1-4 were elucidated primarily by interpretation of NMR spectroscopic data. The absolute configurations of 1-3 were deduced by analogy to the co-isolated metabolites 5 and 6; whereas that of C-12 in 4 was assigned using the modified Mosher method. The cytotoxicity of all compounds against a panel of eight human tumor cell lines were assayed. |
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