| 论文题目: | Nucleoside antibiotics: biosynthesis, regulation, and biotechnology |
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| 作者: | Niu Guoqing Tan Huarong*. |
| 联系作者: | |
| 刊物名称: | Trends in Microbiology |
| 期: | 23 |
| 卷: | 2 |
| 页: | 110-119 |
| 年份: | 2015 |
| 影响因子: | 9.017 |
| 论文下载: | http://www.sciencedirect.com/science/article/pii/S0966842X14002170 |
| 摘要: | The alarming rise in antibiotic-resistant pathogens has coincided with a decline in the supply of new antibiotics. It is therefore of great importance to find and create new antibiotics. Nucleoside antibiotics are a large family of natural products with diverse biological functions. Their biosynthesis is a complex process through multistep enzymatic reactions and is subject to hierarchical regulation. Genetic and biochemical studies of the biosynthetic machinery have provided the basis for pathway engineering and combinatorial biosynthesis to create new or hybrid nucleoside antibiotics. Dissection of regulatory mechanisms is leading to strategies to increase the titer of bioactive nucleoside antibiotics. |
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