| 论文题目: | Kinamycin Biosynthesis Employs a Conserved Pair of Oxidases for B-ring Contraction |
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| 作者: | Bin Wang, Jinwei Ren, Liyuan Li, Fang Guo, Guohui Pan, Guomin Ai, Bertrand Aigle, keqiang Fan, and Keqian* Yang. |
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| 刊物名称: | Chemical Communications |
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| 年份: | 2015 |
| 影响因子: | 6.779 |
| 论文下载: | http://pubs.rsc.org/en/content/articlelanding/2015/cc/c5cc01986a/unauth#!divAbstract |
| 摘要: | Biosynthesis of the diazobenzofluorene kinamycins requires hitherto uncharacterized B-ring contraction. Via detailed genetic and enzymatic analyses we unambiguously characterized the conserved pairs of oxidases, AlpJ and AlpK homologs, as the nature's machinery for the benzofluorenone formation, which paves the way for investigation of the following diazo assembly. |
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