| 论文题目: | Gloeophyllins A-J, Cytotoxic Ergosteroids with Various Skeletons from a Chinese Tibet Fungus Gloeophyllum abietinum |
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| 作者: | Han Jun-Jie, Bao Li, Tao Qiao-Qiao, Yao Yi-Jian, Liu Xing-Zhong, Yin Wen-Bing, and Liu Hong-Wei*. |
| 联系作者: | |
| 刊物名称: | Org Lett |
| 期: | 17 |
| 卷: | 10 |
| 页: | 2538-41 |
| 年份: | 2015 |
| 影响因子: | 5.849 |
| 论文下载: | http://pubs.acs.org/doi/abs/10.1021/acs.orglett.5b01080 |
| 摘要: | Ten new ergosteroids, gloeophyllins A-J (1-10), have been isolated from the solid cultures of Gloeophyllum abietinum. The absolute configurations of 1, 2, and 9 were determined by X-ray crystallographic analysis. Compound 1 has a rare C-nor-D-homosteroid skeleton. Compound 9 possesses an unusual ergostane skeleton having a 10-oxabicyclo [4.3.1] decane moiety replacing 6/5 fused C/D rings. Compound 10 represents the first ergosteroid featuring the cleavage of a C8-C14 bond. The cytotoxicity of 1-10 was tested against the human cancer cell lines K562 and HCT116. The biosynthetic pathway for 1-10 is postulated. |
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