| 论文题目: | New ambuic acid derivatives from the solid culture of Pestalotiopsis neglecta and their nitric oxide inhibitory activity |
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| 作者: | Qi Qiu-Yue, Li Er-Wei, Han Jun-Jie, Pei Yun-Fei, Ma Ke, Bao Li*, Huang Ying, Zhao Feng, and Liu Hong-Wei*. |
| 联系作者: | |
| 刊物名称: | Sci Rep |
| 期: | 5 |
| 卷: | |
| 页: | 9958 |
| 年份: | 2015 |
| 影响因子: | 5.597 |
| 论文下载: | http://www.nature.com/srep/2015/150519/srep09958/full/srep09958.html |
| 摘要: | Four new ambuic acid derivatives (1-4), and four known derivatives (5-8), were isolated from the solid culture of a plant pathogenic fungus Pestalotiopsis neglecta. Their structures were elucidated by extensive NMR experiments. The absolute configuration of the C-16 secondary alcohol in 1 was deduced via the CD data of the in situ formed [Rh2(OCOCF3)4] complex with the acetonide derivative of 1. The absolute configuration in 3 was assigned by comparison of the experimental and simulated electronic circular dichroism (ECD) spectrum. The NMR data of compound 5 was reported for the first time. In the nitric oxide (NO) inhibition assay, compounds 4, 6 and 7 showed inhibitory activity against the NO production in the lipopolysaccharide (LPS)-induced macrophage with IC50 values of 88.66, 11.20, and 20.80 microM, respectively. |
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