| 论文题目: | Synergistic combinations of antifungals and anti-virulence agents to fight against Candida albicans |
|---|---|
| 作者: | Cui Jinhui , Ren Biao , Tong Yaojun , Dai Huanqin* , and Zhang Lixin*. |
| 联系作者: | |
| 刊物名称: | Virulence |
| 期: | 6 |
| 卷: | 4 |
| 页: | 362-371 |
| 年份: | 2015 |
| 影响因子: | 3.672 |
| 论文下载: | http://www.tandfonline.com/doi/full/10.1080/21505594.2015.1039885#.VZsxDNKl_6Q |
| 摘要: | Candida albicans, one of the pathogenic Candida species, causes high mortality rate in immunocompromised and high-risk surgical patients. In the last decade, only one new class of antifungal drug echinocandin was applied. The increased therapy failures, such as the one caused by multi-drug resistance, demand innovative strategies for new effective antifungal drugs. Synergistic combinations of antifungals and anti-virulence agents highlight the pragmatic strategy to reduce the development of drug resistant and potentially repurpose known antifungals, which bypass the costly and time-consuming pipeline of new drug development. Anti-virulence and synergistic combination provide new options for antifungal drug discovery by counteracting the difficulty or failure of traditional therapy for fungal infections. |
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