Erinacerins C-L, Isoindolin-1-ones with alpha-Glucosidase Inhibitory Activity from Cultures of the Medicinal Mushroom Hericium erinaceus----中国科学院微生物研究所

科研成果

论文题目:	Erinacerins C-L, Isoindolin-1-ones with alpha-Glucosidase Inhibitory Activity from Cultures of the Medicinal Mushroom Hericium erinaceus
作者:	Wang Kai Bao Li, Qi Qiuyue, Zhao Feng, Ma Ke, Pei Yunfei, Liu Hongwei*.
联系作者:
刊物名称:	J Nat Prod
期:	78
卷:	1
页:	146-54
年份:	2015
影响因子:	3.395
论文下载:	http://pubs.acs.org/doi/abs/10.1021/np5004388
摘要:	The well-known edible and medicinal mushroom Hericium erinaceus produces various bioactive secondary metabolites. Ten new isoindolin-1-ones, named erinacerins C-L (1-10), together with (E)-5-(3,7-dimethylocta-2,6-dien-1-yl)-4-hydroxy-6-methoxy-2-phenethylisoindolin- 1-one (11) were isolated from the solid culture of H. erinaceus. The structures of new metabolites were established by spectroscopic methods. The absolute configurations of 3, 4, 9, and 10 were assigned by comparing their specific rotations with those of related phthalimidines (13-20). Compounds 5 and 6, 7 and 8, and 9 and 10 are double-bond positional isomers. In a alpha-glucosidase inhibition assay, compounds 2-11 showed inhibitory activity with IC50 values ranging from 5.3 to 145.1 muM. Preliminary structure-activity analysis indicated that the terpenoid side chain and the phenolic hydroxy groups contributed greatly to the alpha-glucosidase inhibitory activity of 1-11. In a cytotoxicity assay, compound 11 also presented weak cytotoxicity against two cell lines, A549 and HeLa, with IC50 values of 49.0 and 40.5 muM.