| 论文题目: | Six new 3,4-seco-27-norlanostane triterpenes from the medicinal mushroom Ganoderma boninense and their antiplasmodial activity and agonistic activity to LXR beta |
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| 作者: | Ma Ke Li Li, Bao Li, He Luwei, Sun Chen, Zhou Bing, Si Shuyi, Liu Hongwei*. |
| 联系作者: | |
| 刊物名称: | Tetrahedron |
| 期: | 71 |
| 卷: | 12 |
| 页: | 1808-1814 |
| 年份: | 2015 |
| 影响因子: | 2.675 |
| 论文下载: | http://www.sciencedirect.com/science/article/pii/S0040402015001350 |
| 摘要: | Six new 3,4-seco-27-norlanostane triterpenes, ganoboninones A-F (1-6), as well as three known compounds ganoboninketals A-C (7-9), were isolated from the fruiting bodies of the medicinal mushroom Ganoderma boninense. The structures of 1-6 were established by extensive spectroscopic analysis. Compounds 1-6 are new 3,4-seco-27-norlanostane triterpenoids featuring with an interesting tetradecahydrobenzo[4,5]indeno[1,7a-c]furan backbone. The absolute configurations in 1-6 were determined by CD spectral analysis, and ECD calculation. In an in vitro anti-Plasmodium falciparum bioassay, compounds 1, 2, and 6 showed antimalarial effects with IC50 values of 27.36, 15.68, and 2.03 mu M, respectively. In a transactivation assay, compounds 5, 7, 8, and 9 showed agonistic activity to LXR beta with EC50 value of 203.00, 8.32, 257.00, and 86.70 nM, respectively. (C) 2015 Elsevier Ltd. All rights reserved. |
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